Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of enterococcus faecalis and its analogs

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 10, 2001, Pages 2322-2325

  Nakayama, Jiro ^a,b   Cao, Yong ^a   Horii, Takaaki ^a   Sakuda, Shohei ^a   Nagasawa, Hiromichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Enterococcus faecalis; Gelatinase biosynthesis activating pheromone; Peptide lactone; Peptide pheromone; Quorum sensing

Indexed keywords

ENTEROCOCCUS FAECALIS;

CYCLOPEPTIDE; GELATINASE BIOSYNTHESIS ACTIVATING PHEROMONE; GELATINASE BIOSYNTHESIS-ACTIVATING PHEROMONE; LACTONE; PHEROMONE;

AMINO ACID SEQUENCE; ARTICLE; ENTEROCOCCUS FAECALIS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; ENTEROCOCCUS FAECALIS; LACTONES; PEPTIDES, CYCLIC; PHEROMONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035490516     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.2322     Document Type: Article

References (14)

1. Hardman, A. M., Stewart, G. S., and Williams, P., Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria. Antonie van Leeuwenhoek, 74, 199-210 (1998).
2. Gray, K. M., Intercellular communication and group behavior in bacteria. Trends Microbiol., 5, 184-188 (1997).
3. Dunny, G. M. and Leonard, B. A., Cell-cell communication in gram-positive bacteria. Annu. Rev. Microbiol., 51, 527-564 (1997).
4. Kleerebezem, M., Quadri, L. E., Kuipers, O. P., and de Vos, W. M., Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol. Microbiol., 24, 895-904 (1997).
5. Qin, X., Singh, K. V., Weinstock, G. M., and Murray, B. E., Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence. Infect. Immun., 68, 2579-2586 (2000).
6. Hancock, L. E. and Gilmore, M. S., Pathogenicity of enterococci. In "Gram-positive pathogens," eds. Fischetti, V. A., Novick, R. P., Ferretti, J. J., Portnoy, D. A., and Rood, J. I., American Society for Microbiology, Washington D.C., pp. 251-258 (1999).
7. Nakayama, J., Cao, Y., Horii, T., Sakuda, S., Akkermans, A. D. L., de Vos, W. M., and Nagasawa, H., Gelatinase biosynthesis activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis. Mol. Microbiol., 41, 145-154 (2001).
8. Chang, C. D. and Meienhofer, J. Solid-phase peptide synthesis using mild base cleavage of N alpha-fluorenylmethyloxycarbonylamino acids, exemplified by a synthesis of dihydrosomatostatin. Int. J. Pept. Protein Res., 11, 246-249. (1978).
9. Hayashi, T. and Sasagawa, T., A method for identifying the carboxy terminal amino acid of a protein. Anal. Biochem., 209, 163-168 (1993).
10. Goodman, M. and McGahren, W. J., Retention and racemization reactions during peptide synthesis. J. Am. Chem. Soc., 88, 3887-3888. (1966).
11. Mori, M., Sakagami, Y., Narita, M., Isogai, A., Fujino, M., Kitada, C., Craig, R. A., Clewell, D. B., and Suzuki, A., Isolation and structure of the bacterial sex pheromone, cAD1, that induces plasmid transferin Streptococcus faecalis. FEBS Lett., 178, 97-100 (1984).
12. Dunny, G. M., Craig, R. A., Carron, R. L., and Clewell, D. B., Plasmid transfer in Streptococcus faecalis: production of multiple sex pheromones by recipients. Plasmid, 2, 454-465 (1979).
13. Finch, R. G., Pritchard, D. I., Bycroft, B. W., Williams, P., and Stewart, G. S., Quorum sensing: a novel target for anti-infective therapy. J. Antimicrob. Chemother., 42, 569-571 (1998).
14. Lyon, G. J., Mayville, P., Muir, T. W., and Novick, R. P., Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, agrC. Proc. Natl. Acad. Sci. USA, 97, 13330-13335 (2000).