Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 2279-2789

  Nemmar, Abderrahim ^a   Albarwani, Sulayma ^b   Beegam, Sumaya ^a   Yuvaraju, Priya ^a   Yasin, Javed ^a   Attoub, Samir ^a   Ali, Badreldin H ^b  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Amorphous silica nanoparticles; Systemic inflammation; Thrombosis; Toxicity

Indexed keywords

8 ISOPROSTANE; CATALASE; FIBRINOGEN; GLUTATHIONE TRANSFERASE; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NANOPARTICLE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SILICA NANOPARTICLE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL REACTIVITY; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; FIBRINOGEN BLOOD LEVEL; HOMEOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTIAL THROMBOPLASTIN TIME; PARTICLE SIZE; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; VASCULAR HOMEOSTASIS; VASODILATATION; VENULE; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOLOGY; MATERIALS TESTING; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTE ACTIVATION; THROMBOSIS; TOXICITY; WISTAR KYOTO RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEOSTASIS; HUMANS; MALE; MATERIALS TESTING; NANOPARTICLES; PARTICLE SIZE; PLATELET ACTIVATION; RATS; RATS, INBRED WKY; SILICON DIOXIDE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOSIS;

EID: 84901918642     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S52818     Document Type: Article

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