Editorial: Molecular obesity research: Lessons learned?

Molecular Endocrinology

Volumn 28, Issue 6, 2014, Pages 785-789

  Ahima, Rexford S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERMEDIN; LEPTIN; LEPTIN RECEPTOR; MELANIN CONCENTRATING HORMONE; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; PROTEIN TYROSINE PHOSPHATASE 1B; RECOMBINANT LEPTIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRACE ELEMENT; TRIACYLGLYCEROL;

ADIPOSE TISSUE; AGRICULTURE; ARCUATE NUCLEUS; BODY COMPOSITION; BODY MASS; CHILDHOOD OBESITY; DEVELOPING COUNTRY; DIABETES MELLITUS; DIABETIC OBESITY; EDITORIAL; FATTY ACID OXIDATION; FEEDING; FOOD PROCESSING; GENE MUTATION; GLUCOSE BLOOD LEVEL; HEALTH CARE COST; HUMAN; HYPERPHAGIA; HYPOTHALAMIC AMENORRHEA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INFECTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; ISCHEMIC HEART DISEASE; LATERAL HYPOTHALAMUS; LEPTIN DEFICIENCY; LIPID DIET; LIPID STORAGE; LIPODYSTROPHY; LOSS OF FUNCTION MUTATION; MALNUTRITION; MEDIOBASAL HYPOTHALAMUS; METABOLIC DISORDER; NEOPLASM; NON COMMUNICABLE DISEASE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL VALUE; OBESITY; OSTEOARTHRITIS; OVERNUTRITION; PARABIOSIS; PATHOGENESIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SATIETY; SEDENTARY LIFESTYLE; SLEEP DISORDERED BREATHING; STARVATION; SUGAR INTAKE; THERMOGENESIS; TRAFFIC AND TRANSPORT; URBANIZATION; WEIGHT REDUCTION; ANIMAL; ENERGY METABOLISM; HYPOTHALAMUS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ENERGY METABOLISM; HUMANS; HYPOTHALAMUS; LEPTIN; OBESITY;

EID: 84901913303     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1140     Document Type: Editorial

References (32)

1. Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol. 1969;217:1298-1304.
2. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973;9:294-298.
3. Obesity and overweight. Fact sheet no. 311, 2013. World Health Organization website. http://www.who.int/mediacentre/factsheets/ fs311/en/. Accessed April 29, 2014.
4. Ahima RS. Digging deeper into obesity. J Clin Invest. 2011;121: 2076-2079.
5. Adult obesity facts. Centers for Disease Control and Prevention website. http://www.cdc.gov/obesity/data/adult.html. Accessed April 29, 2014.
6. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
7. Ahima RS, Saper CB, Flier JS, Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol. 2000;21:263-307.
8. Ingalls AM, Dickei MM, Snell GD. Obese, a new mutation in the house mouse. J Hered. 1950;41:317-318.
9. Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science. 1966;153:1127-1128.
10. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269: 543-546.
11. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouseOBprotein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
12. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543.
13. Tartaglia LA, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-1271.
14. Chua SC Jr, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996;271:994-996.
15. Baumann H, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA. 1996;93:8374-8378.
16. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537-556.
17. Gautron L, Elmquist JK. Sixteen years and counting: an update on leptin in energy balance. J Clin Invest. 2011;121:2087-2093.
18. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:903-908.
19. Clément K, Vaisse C, Lahlou N. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398-401.
20. Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab. 1998;83:1407-1413.
21. Ahima RS, Prabakaran D, Mantzoros C. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250-252.
22. Ahima RS, Kelly J, Elmquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology. 1999;140:4923-4931.
23. Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med. 2002;346:570-578.
24. Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110:1093-1103.
25. Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA. 1999;282:1568-1575.
26. Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS. Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell Metab. 2013;18:29-42.
27. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The bodymass index of twins who have been reared apart. N Engl J Med. 1990;322:1483-1487.
28. Ramachandrappa S, Farooqi IS. Genetic approaches to understanding human obesity. J Clin Invest. 2011;121:2080-2086.
29. Ahima RS, Lazar MA. Physiology. The health risk of obesity-better metrics imperative. Science. 2013;341:856-858.
30. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18: 363-374.
31. Bray GA, Ryan DH. Update on obesity pharmacotherapy. Ann NY Acad Sci. 2014;1311:1-13.
32. Miras AD, le Roux CW. Mechanisms underlying weight loss after bariatric surgery. Nat Rev Gastroenterol Hepatol. 2013;10:575-584.