Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol-induced hepatotoxicity in mice

Journal of the Science of Food and Agriculture

Volumn 94, Issue 9, 2014, Pages 1764-1771

  Cui, Yan ^a   Ye, Qing ^a   Wang, Heya ^a   Li, Yingchao ^a   Yao, Weirong ^a   Qian, He ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Aloe vera polysaccharides; Chronic alcoholic liver injury; Hepatoprotective; Inflammation; Lipid accumulation; Oxidative stress

Indexed keywords

ALOE VERA; MUS;

ALCOHOL; AMINOTRANSFERASE; AMPK ALPHA2 SUBUNIT, MOUSE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B; MALONALDEHYDE; NF-KAPPAB INHIBITOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; POLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALOE; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIPID METABOLISM; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYTOTHERAPY;

ALOE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; ETHANOL; I-KAPPA B PROTEINS; LIPID METABOLISM; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MALONDIALDEHYDE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; PPAR GAMMA; TOLL-LIKE RECEPTOR 4; TRANSAMINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901856482     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.6489     Document Type: Article

References (46)

1. Zhuang H and Zhang JH, Epidemiology of alcoholic liver disease. Chin J Gastroenterol 8:294-297 (2003).
2. Albano E, Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9-16 (2008).
3. Ramaiah SK, Rivera C and Arteel GE, Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int J Toxicol 23:217-231 (2004).
4. An L, Wang X and Cederbaum AI, Cytokines in alcoholic liver disease. Arch Toxicol 86:1337-1348 (2012).
5. Stewart S, Jones D and Day CP, Alcoholic liver disease: new insights into mechanisms and preventative strategies. Trends Mol Med 7:408-413 (2001).
6. Zakhari S, Overview: how is alcohol metabolized by the body? Alcohol Res Health 29:245-254 (2006).
7. Hirayama C, Kishimoto Y, Wakushima T and Murawaki Y, Mechanism of the protective action of thiol compounds in ethanol-induced liver injury. Biochem Pharmacol 32:321-325 (1983).
8. Zhao J, Chen H and Li Y, Protective effect of bicyclol on acute alcohol-induced liver injury in mice. Eur J Pharmacol 586:322-331 (2008).
9. Li GL, Ye Y, Kang JJ, Yao XY, Zhang YZ, Jiang W, et al., l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes. Food Chem Toxicol 50:363-372 (2012).
10. Wang MC, Zhu PL, Jiang CX, Ma LP, Zhang ZJ and Zeng XX, Preliminary characterization, antioxidant activity in vitro and hepatoprotective effect on acute alcohol-induced liver injury in mice of polysaccharides from the peduncles of Hovenia dulcis. Food Chem Toxicol 50:2964-2970 (2012).
11. Ding RB, Tian K, Huang LL, He CW, Jiang Y, Wang YT, et al., Herbal medicines for the prevention of alcoholic liver disease: a review. J Ethnopharmacol 144:457-465 (2012).
12. Rejitha S, Prathibha P and Indira M, Amelioration of alcohol-induced hepatotoxicity by the administration of ethanolic extract of Sida cordifolia Linn. Br J Nutr 108:1256-1263 (2012).
13. Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC and Bergheim I, Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr 139:482-487 (2009).
14. Hamman JH, Composition and applications of Aloe vera leaf gel. Molecules 13:1599-1616 (2008).
15. Gbadegesin MA, Odunola OA, Akinwumi KA and Osifeso OO, Comparative hepatotoxicity and clastogenicity of sodium arsenite and three petroleum products in experimental Swiss albino mice: the modulatory effects of Aloe vera gel. Food Chem Toxicol 47:2454-2457 (2009).
16. Etim OE, Farombi EO, Usoh IF and Akpan EJ, The protective effect of Aloe vera juice on lindane induced hepatotoxicity and genotoxicity. Pak J Pharmaceut Sci 19:337-340 (2006).
17. Nayak V, Gincy TB, Prakash M, Joshi C, Rao SS, Somayaji SN, et al., Hepatoprotective activity of Aloe vera gel against paracetamol induced hepatotoxicity in albino rats. Asian J Pharmaceut Biol Res 1:94-98 (2011).
18. Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, et al., Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol 111:560-566 (2007).
19. Saito M, Tanaka M, Misawa E, Yamada M, Yamauchi K and Iwatsuki K, Aloe vera gel extract attenuates ethanol-induced hepatic lipid accumulation by suppressing the expression of lipogenic genes in mice. Biosci Biotechnol Biochem 76:2049-2054 (2012).
20. Saka WA, Akhigbe RE, Ishola OS, Ashamu EA, Olayemi OT and Adeleke GE, Hepatotherapeutic effect of Aloe vera in alcohol-induced hepatic damage. Pak J Biol Sci 14:742-746 (2011).
21. Xu C, Ruan XM, Li HS, Guo BX, Ren XD, Shuang JL, et al., Anti-adhesive effect of an acidic polysaccharide from Aloe vera L. var. chinensis (Haw.) Berger on the binding of Helicobacter pylori to the MKN-45 cell line. J Pharm Pharmacol 62:1753-1759 (2010).
22. Ye Q, Wang HY and Qian H, Protective effects of crude aloe polysaccharides and aloin on mice with acute liver injury induced by alcohol. Sci Technol Food Ind 33:355-358 (2012).
23. Wu JH, Xu C, Shan CY and Tan RX, Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis. Life Sci 78:622-630 (2006).
24. Staub AM, Removal of protein - Sevag method. Meth Carbohydr Chem 5:5-6 (1965).
25. Bradford MM, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254 (1976).
26. Arosio B, Gagliano N, Fusaro LMP, Parmeggiani L, Tagliabue J, Galetti P, et al., Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacol Toxicol 87:229-233 (2000).
27. Wang Y, Millonig G, Nair J, Patsenker E, Stickel F, Mueller S, et al., Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology 50:453-461 (2009).
28. Donohue TM, Alcohol-induced steatosis in liver cells. World J Gastroenterol 13:4974-4978 (2007).
29. Sozio M and Crabb DW, Alcohol and lipid metabolism. Am J Physiol Endocrinol Metabol 295:E10- E16 (2008).
30. Chen XC, Sebastian BM and Nagy LE, Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. Am J Physiol Endocrinol Metabol 292:E621-E628 (2007).
31. Awazawa M, Ueki K, Inabe K, Yamauchi T, Kaneko K, Okazaki Y, et al., Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem Biophys Res Commun 382:51-56 (2009).
32. You M and Crabb DW, Recent advances in alcoholic liver disease. II. Minireview: molecular mechanisms of alcoholic fatty liver. Am J Physiol Gastrointest Liver Physiol 287:G1-G6 (2004).
33. You M, Matsumoto M, Pacold CM, Cho WK and Crabb DW, The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127:1798-1808 (2004).
34. Zeng T, Zhang CL, Song FY, Zhao XL and Xie KQ, Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1. Food Chem Toxicol 50:485-491 (2012).
35. Yurt B and Celik I, Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats. Food Chem Toxicol 49:508-513 (2011).
36. Albano E, Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 65:278-290 (2006).
37. Noh JR, Kim YH, Gang GT, Hwang JH, Lee HS, Ly SY, et al., Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food Chem Toxicol 49:1537-1543 (2011).
38. Khanal T, Choi JH, Hwang YP, Chung YC and Jeong HG, Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice. Food Chem Toxicol 47:530-535 (2009).
39. Yu Z, Che J, Ma X and He J, Effect of Aloe vera polysaccharides on immunity and antioxidant activities in oral ulcer animal models. Carbohydr Polym 75:307-311 (2009).
40. Liu CH, Wang C, Xu ZL and Wang Y, Isolation, chemical characterization and antioxidant activities of two polysaccharides from the gel and the skin of Aloe barbadensis Miller irrigated with sea water. Process Biochem 42:961-970 (2007).
41. Hu SL, Yin S, Jiang XD, Huang DB and Shen G, Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. Eur J Pharmacol 616:287-292 (2009).
42. Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez FJ, et al., Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress. J Hepatol 50:1236-1246 (2009).
43. Lu J, Xiao W, Geng Z, Liu D and Wang Y, Effect of aloe polysaccharides pretreatment on the cerebral inflammatory response and lipid peroxidation in severe hemorrhagic shock rats first entering high altitude. Chin J Surg 50:655-658 (2012).
44. Reynolds T and Dweck AC, Aloe vera leaf gel: a review update. J Ethnopharmacol 68:3-37 (1999).
45. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, et al., Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 42:349-361 (2008).
46. Szabo G and Bala S, Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 16:1321-1329 (2010).