P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps

International Forum of Allergy and Rhinology

Volumn 4, Issue 6, 2014, Pages 488-494

  Bleier, Benjamin S ^a   Nocera, Angela L ^b   Iqbal, Hufsa ^b   Hoang, John D ^b   Alvarez, Ulises ^b   Feldman, Rachel E ^a   Han, Xue ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Boston University   (United States)

Author keywords

Chronic sinusitis with nasal polyps; Immunomodulator; Nasal epithelium; P glycoprotein; Th2 inflammation

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 25; INTERLEUKIN 6; INTERLEUKIN 8; MULTIDRUG RESISTANCE PROTEIN; TOLL LIKE RECEPTOR 4; VALSPODAR; CALCEIN; CYCLOSPORIN DERIVATIVE; CYTOKINE; FLUORESCEIN DERIVATIVE; LIPOPOLYSACCHARIDE;

ARTICLE; CALCEIN-AM ASSAY; CELL CULTURE; CELL SURVIVAL; CHRONIC INFLAMMATION; CHRONIC SINUSITIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EXPLANT; HUMAN; HUMAN CELL; HUMAN TISSUE; LUMINANCE; NOSE POLYP; PRIORITY JOURNAL; RANK SUM TEST; TH2 CELL; ANTAGONISTS AND INHIBITORS; CHRONIC DISEASE; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PRIMARY CELL CULTURE; SINUSITIS;

CELLS, CULTURED; CHRONIC DISEASE; CYCLOSPORINS; CYTOKINES; EPITHELIAL CELLS; FLUORESCEINS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LIPOPOLYSACCHARIDES; NASAL POLYPS; P-GLYCOPROTEIN; PRIMARY CELL CULTURE; SINUSITIS; TH2 CELLS;

EID: 84901847195     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21316     Document Type: Article

References (28)

1. Chin D, Harvey RJ. Nasal polyposis: an inflammatory condition requiring effective anti-inflammatory treatment. Curr Opin Otolaryngol Head Neck Surg. 2013;21:23-30.
2. Sachse F, Becker K, von Eiff C, et al. Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro. Allergy. 2010;65:1430-1437.
3. Damm M, Quante G, Rosenbohm J, et al. Proinflammatory effects of Staphylococcus aureus exotoxin B on nasal epithelial cells. Otolaryngol Head Neck Surg. 2006;134:245-249.
4. Bleier BS. Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis. Int Forum Allergy Rhinol. 2012;2:122-125.
5. Bleier BS, Nocera AL, Iqbal H, et al. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013;3:433-438.
6. Lane AP, Truong-Tran QA, Schleimer RP. Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol. 2006;20:138-144.
7. Bachert C, Gevaert P, van Cauwenberge P. Staphylococcus aureus enterotoxins: a key in airway disease? Allergy. 2002;57:480-487.
8. Van Crombruggen K, Zhang N, Gevaert P, et al. Pathogenesis of chronic rhinosinusitis: inflammation. J Allergy Clin Immunol. 2011;128:728-732.
9. Olze H, Förster U, Zuberbier T, et al. Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3. Rhinology. 2006;44:145-150.
10. Lalaker A, Nkrumah L, Lee WK, et al. Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitro. Am J Rhinol Allergy. 2009;23:8-14.
11. Nickel W. The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur J Biochem. 2003;270:2109-2119.
12. Fernandez C, Buyse M, German-Fattal M, et al. Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality. J Pharm Pharm Sci. 2004;7:359-371.
13. Kooij G, Backer R, Koning JJ, et al. P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One. 2009;4:e8212.
14. Marty V, Médina C, Combe C, et al. ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells. Glia. 2005;49:511-519.
15. Stein U, Walther W, Shoemaker RH. Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. Br J Cancer. 1996;74:1384-1391.
16. Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012;(23):3 p preceding table of contents, 1-298.
17. Mjösberg JM, Trifari S, Crellin NK, et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011;12:1055-1062.
18. Peters AT, Kato A, Zhang N, et al. Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2010;125:397-403.
19. Reh DD, Wang Y, Ramanathan M Jr, et al. Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J Rhinol Allergy. 2010;24:105-109.
20. Wisniewski JA, Borish L. Novel cytokines and cytokine-producing T cells in allergic disorders. Allergy Asthma Proc. 2011;32:83-94.
21. Glavinas H, von Richter O, Vojnits K, et al. Calcein assay: a high-throughput method to assess P-gp inhibition. Xenobiotica. 2011;41:712-719.
22. Morjani H, Madoulet C. Immunosuppressors as multidrug resistance reversal agents. Methods Mol Biol. 2010;596:433-446.
23. Iqbal M, Gibb W, Matthews SG. Corticosteroid regulation of P-glycoprotein in the developing blood-brain barrier. Endocrinology. 2011;152:1067-1079.
24. Cho HJ, Choi MK, Lin H, et al. Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study. J Pharm Pharmacol. 2011;63:385-391.
25. Yu N, Di Q, Liu H, et al. Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats. Mediators Inflamm. 2011;2011:670613.
26. Putra AB, Nishi K, Shiraishi R, et al. Jellyfish collagen stimulates production of TNF-α and IL-6 by J774.1 cells through activation of NF-κB and JNK via TLR4 signaling pathway. Mol Immunol. 2013;58:32-37.
27. Kulkarni R, Rampersaud R, Aguilar JL, et al. Cigarette smoke inhibits airway epithelial cell innate immune responses to bacteria. Infect Immun. 2010;78:2146-2152.
28. Shin SH, Lee SH, Jeong HS, et al. The effect of nasal polyp epithelial cells on eosinophil activation. Laryngoscope. 2003;113:1374-1377.