Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: A novel pathogenic mechanism for hypertrophic cardiomyopathy

Archives of Biochemistry and Biophysics

Volumn 552-553, Issue , 2014, Pages 21-28

  Moore, Rachel K ^a   Abdullah, Salwa ^a   Tardiff, Jil C ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Hypertrophic cardiomyopathy; Thin filaments; Troponin; Weak binding

Indexed keywords

MYOSIN ADENOSINE TRIPHOSPHATASE; TROPONIN;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE; GENE MUTATION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; IN VIVO STUDY; IONIC STRENGTH; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SARCOMERE; STATIC ELECTRICITY; TNT 1 GENE;

MUS MUSCULUS;

HYPERTROPHIC CARDIOMYOPATHY; THIN FILAMENTS; TROPONIN; WEAK BINDING;

ACTOMYOSIN; AMINO ACID SEQUENCE; ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYOSIN SUBFRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SARCOMERES; SEQUENCE ALIGNMENT; TROPOMYOSIN; TROPONIN T;

EID: 84901836679     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2014.01.016     Document Type: Article

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