Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression

FASEB Journal

Volumn 28, Issue 6, 2014, Pages 2725-2735

  Ning, Chen ^a,b,c   Wen, Jiaming ^a,d   Zhang, Yujin ^a   Dai, Yingbo ^a,b   Wang, Wei ^a,b   Zhang, Weiru ^a,b   Qi, Lin ^b   Grenz, Almut ^e   Eltzschig, Holger K ^e   Blackburn, Michael R ^a,f   Kellems, Rodney E ^a,f   Xia, Yang ^a,d,f  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS   (United States)

Author keywords

Hypoxia inducible factor; Phosphodiesterase 5; Sickle cell disease

Indexed keywords

ADENOSINE A2B RECEPTOR; HYPOXIA INDUCIBLE FACTOR; PHOSPHODIESTERASE V;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME THERAPY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIAPISM; PRIORITY JOURNAL; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; TISSUES;

HYPOXIA-INDUCIBLE FACTOR; PHOSPHODIESTERASE-5; SICKLE CELL DISEASE;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ADENOSINE DEAMINASE; AGAMMAGLOBULINEMIA; ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, SCID; MICE, TRANSGENIC; PENILE ERECTION; PENIS; PRIAPISM; RECEPTOR, ADENOSINE A2B; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; XANTHINES;

EID: 84901832588     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-247833     Document Type: Article

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