-
1
-
-
0029843953
-
Thalassemia: A global public health problem
-
Weatherall DJ, Clegg JB: Thalassemia: a global public health problem. Nature Med 1996, 2:847-849.
-
(1996)
Nature Med
, vol.2
, pp. 847-849
-
-
Weatherall, D.J.1
Clegg, J.B.2
-
2
-
-
0022389290
-
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
-
Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS: Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination. Nature 1985, 317:230-234.
-
(1985)
Nature
, vol.317
, pp. 230-234
-
-
Smithies, O.1
Gregg, R.G.2
Boggs, S.S.3
Koralewski, M.A.4
Kucherlapati, R.S.5
-
3
-
-
0023646810
-
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
-
Thomas KR, Capecchi MR: Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987, 51:503-512.
-
(1987)
Cell
, vol.51
, pp. 503-512
-
-
Thomas, K.R.1
Capecchi, M.R.2
-
4
-
-
0024296027
-
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
-
Mansour SL, Thomas KR, Capecchi MR: Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 1988, 336:348-352.
-
(1988)
Nature
, vol.336
, pp. 348-352
-
-
Mansour, S.L.1
Thomas, K.R.2
Capecchi, M.R.3
-
5
-
-
0024509622
-
A review of the molecular genetics of the human α-globin gene cluster
-
Higgs DR, Vickers MA, Wilkie AOM, Pretorius IM, Jarman AP, Weatherall DJ: A review of the molecular genetics of the human α-globin gene cluster. Blood 1989, 73:1081-1104.
-
(1989)
Blood
, vol.73
, pp. 1081-1104
-
-
Higgs, D.R.1
Vickers, M.A.2
Wilkie, A.O.M.3
Pretorius, I.M.4
Jarman, A.P.5
Weatherall, D.J.6
-
6
-
-
0024947112
-
Alpha thalassemia
-
Liebhaber SA: Alpha thalassemia. Hemoglobin 1989, 13:685-731.
-
(1989)
Hemoglobin
, vol.13
, pp. 685-731
-
-
Liebhaber, S.A.1
-
7
-
-
0017064085
-
Radiation-induced mutations at mouse hemoglobin loci
-
Russell LB, Russell WL, Popp RA, Vaughan C, Jacobson KB: Radiation-induced mutations at mouse hemoglobin loci. Proc Natl Acad Sci U S A 1976, 73:2843-2846.
-
(1976)
Proc Natl Acad Sci U S A
, vol.73
, pp. 2843-2846
-
-
Russell, L.B.1
Russell, W.L.2
Popp, R.A.3
Vaughan, C.4
Jacobson, K.B.5
-
8
-
-
0019153312
-
Linkage of genes for adult α-globin and embryonic α-like globin chains
-
Whitney III JB, Russell ES: Linkage of genes for adult α-globin and embryonic α-like globin chains. Proc Natl Acad Sci U S A 1980, 77:1087-1090.
-
(1980)
Proc Natl Acad Sci U S A
, vol.77
, pp. 1087-1090
-
-
Whitney III, J.B.1
Russell, E.S.2
-
9
-
-
0019194108
-
Effects of alpha thalassemia on mouse development
-
Popp RA, Bradshaw BS, Skow LC: Effects of alpha thalassemia on mouse development. Differentiation 1980, 17:205-210.
-
(1980)
Differentiation
, vol.17
, pp. 205-210
-
-
Popp, R.A.1
Bradshaw, B.S.2
Skow, L.C.3
-
10
-
-
0028978479
-
Lethal α-thalassaemia created by gene targeting in mice and its genetic rescue
-
Pászty C, Mohandas N, Stevens ME, Loring JF, Liebhaber SA, Brion CM, Rubin EM: Lethal α-thalassaemia created by gene targeting in mice and its genetic rescue. Nature Genet 1995, 11:33-39. Reports the deletion of both adult α-globin genes and the creation of the first mouse model for severe α-thalassemia. The thalassemic mice are rescued from lethality using a human α-globin transgene. This α-globin deletion is a critical genetic component for the development of murine models of sickle cell disease.
-
(1995)
Nature Genet
, vol.11
, pp. 33-39
-
-
Pászty, C.1
Mohandas, N.2
Stevens, M.E.3
Loring, J.F.4
Liebhaber, S.A.5
Brion, C.M.6
Rubin, E.M.7
-
11
-
-
0030993199
-
Mouse models for the α- and β-thalassemias: The power of transgenic and gene knock-out approaches
-
Pászty C: Mouse models for the α- and β-thalassemias: the power of transgenic and gene knock-out approaches. Int J Pediatr Hematol/Oncol 1997, 4:75-84.
-
(1997)
Int J Pediatr Hematol/Oncol
, vol.4
, pp. 75-84
-
-
Pászty, C.1
-
12
-
-
0029841814
-
Inactivation of mouse α-globin gene by homologous recombination: Mouse model of hemoglobin H disease
-
Chang J, Lu RH, Xu SM, Meneses J, Chan K, Pedersen R, Kan YW: Inactivation of mouse α-globin gene by homologous recombination: mouse model of hemoglobin H disease. Blood 1996, 88:1846-1851.
-
(1996)
Blood
, vol.88
, pp. 1846-1851
-
-
Chang, J.1
Lu, R.H.2
Xu, S.M.3
Meneses, J.4
Chan, K.5
Pedersen, R.6
Kan, Y.W.7
-
14
-
-
0343597187
-
Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea
-
Johnson FM, Lewis SE: Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea. Proc Natl Acad Sci U S A 1981, 78:3138-3141.
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 3138-3141
-
-
Johnson, F.M.1
Lewis, S.E.2
-
15
-
-
0020564074
-
A mouse model for β-thalassemia
-
Skow LC, Burkhart BA, Johnson FM, Popp RA, Popp DM, Goldberg SZ, Anderson WF, Barnett LB, Lewis SE: A mouse model for β-thalassemia. Cell 1983, 34:1043-1052.
-
(1983)
Cell
, vol.34
, pp. 1043-1052
-
-
Skow, L.C.1
Burkhart, B.A.2
Johnson, F.M.3
Popp, R.A.4
Popp, D.M.5
Goldberg, S.Z.6
Anderson, W.F.7
Barnett, L.B.8
Lewis, S.E.9
-
16
-
-
0021892008
-
Hematology of a murine β-thalassemia: A longitudinal study
-
Popp RA, Popp DM, Johnson FM, Skow LC, Lewis SE: Hematology of a murine β-thalassemia: a longitudinal study. Ann N Y Acad Sci 1985, 445:432-444.
-
(1985)
Ann N Y Acad Sci
, vol.445
, pp. 432-444
-
-
Popp, R.A.1
Popp, D.M.2
Johnson, F.M.3
Skow, L.C.4
Lewis, S.E.5
-
17
-
-
0027417591
-
Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene
-
Shehee RW, Oliver P, Smithies O: Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene. Proc Natl Acad Sci U S A 1993, 90:3177-3181.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 3177-3181
-
-
Shehee, R.W.1
Oliver, P.2
Smithies, O.3
-
18
-
-
0029045603
-
min-globin genes in embryonic stem cells
-
min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A 1995, 92:9259-9263. Reports the deletion of both adult β-globin genes and the creation of a mouse model of β-thalassemia intermedia. This β-globin deletion is a critical genetic component for the development of murine models of sickle cell disease.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9259-9263
-
-
Ciavatta, D.J.1
Ryan, T.M.2
Farmer, S.C.3
Townes, T.M.4
-
20
-
-
4243891216
-
A viable murine model of severe β-thalassemia: Exploration of the role of programmed cell death (PCD) in ineffective erythropoiesis (IE)
-
Pászty C, Mohandas N, Rubin EM, Kuypers F, Yuan J, Ma L, Schrier SL: A viable murine model of severe β-thalassemia: exploration of the role of programmed cell death (PCD) in ineffective erythropoiesis (IE) [abstract]. Blood 1996, 88:152a. Creation of a mouse model that closely mimics β-thalassemia major/Cooley's anemia. The role of apoptosis in the pathophysiology of β-thalassemia is addressed.
-
(1996)
Blood
, vol.88
-
-
Pászty, C.1
Mohandas, N.2
Rubin, E.M.3
Kuypers, F.4
Yuan, J.5
Ma, L.6
Schrier, S.L.7
-
21
-
-
0025190255
-
A transgenic mouse model of sickle cell disorder
-
Greaves DR, Fraser P, Vidai MA, Hedges MJ, Ropers D, Luzzatto L, Grosveld F: A transgenic mouse model of sickle cell disorder. Nature 1990, 343:183-185.
-
(1990)
Nature
, vol.343
, pp. 183-185
-
-
Greaves, D.R.1
Fraser, P.2
Vidai, M.A.3
Hedges, M.J.4
Ropers, D.5
Luzzatto, L.6
Grosveld, F.7
-
22
-
-
0025191104
-
Human sickle hemoglobin in transgenic mice
-
Ryan TM, Townes TM, Reilly MP, Asakura T, Palmiter RD, Brinster RL, Behringer RR: Human sickle hemoglobin in transgenic mice. Science 1990, 247:566-568.
-
(1990)
Science
, vol.247
, pp. 566-568
-
-
Ryan, T.M.1
Townes, T.M.2
Reilly, M.P.3
Asakura, T.4
Palmiter, R.D.5
Brinster, R.L.6
Behringer, R.R.7
-
24
-
-
0027052258
-
s- and α-globins in transgenic mice: Erythrocyte abnormalities, organ damage, and the effect of hypoxia
-
s- and α-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci U S A 1992, 89:12155-12159.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 12155-12159
-
-
Fabry, M.E.1
Costantini, F.2
Pachnis, A.3
Suzuka, S.M.4
Bank, N.5
Aynedjian, H.S.6
Factor, S.M.7
Nagel, R.L.8
-
25
-
-
0026036041
-
Hypoxia-induced in vivo sickling of transgenic mouse red cells
-
Rubin EM, Witkowska HE, Spangler E, Curtin P, Lubin BH, Mohandas N, Clift SM: Hypoxia-induced in vivo sickling of transgenic mouse red cells. J Clin Invest 1991, 87:639-647.
-
(1991)
J Clin Invest
, vol.87
, pp. 639-647
-
-
Rubin, E.M.1
Witkowska, H.E.2
Spangler, E.3
Curtin, P.4
Lubin, B.H.5
Mohandas, N.6
Clift, S.M.7
-
26
-
-
0025941960
-
Towards a transgenic mouse model of sickle cell disease: Hemoglobin SAD
-
Trudel M, Saadane N, Garel M-C, Bardakdjian-Michau J, Blouquit Y, Guerquin-Kern J-L, Rouyer-Fessard P, Vidaud D, Pachnis A, Roméo P-H, Beuzard Y, Costantini F: Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD. EMBO J 1991, 10:3157-3165.
-
(1991)
EMBO J
, vol.10
, pp. 3157-3165
-
-
Trudel, M.1
Saadane, N.2
Garel, M.-C.3
Bardakdjian-Michau, J.4
Blouquit, Y.5
Guerquin-Kern, J.-L.6
Rouyer-Fessard, P.7
Vidaud, D.8
Pachnis, A.9
Roméo, P.-H.10
Beuzard, Y.11
Costantini, F.12
-
27
-
-
0028032847
-
Sickle cell disease of transgenic SAD mice
-
Trudel M, De Paepe ME, Chretien N, Saadane N, Jacmain J, Sorette M, Hoang T, Beuzard Y: Sickle cell disease of transgenic SAD mice. Blood 1994, 84:3189-3197.
-
(1994)
Blood
, vol.84
, pp. 3189-3197
-
-
Trudel, M.1
De Paepe, M.E.2
Chretien, N.3
Saadane, N.4
Jacmain, J.5
Sorette, M.6
Hoang, T.7
Beuzard, Y.8
-
28
-
-
0029144487
-
A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity
-
Fabry ME, Sengupta A, Suzuka SM, Costantini F, Rubin EM, Hofrichter J, Christoph G, Manci E, Culberson D, Factor SM, Nagel RL: A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. Blood 1995, 86:2419-2428.
-
(1995)
Blood
, vol.86
, pp. 2419-2428
-
-
Fabry, M.E.1
Sengupta, A.2
Suzuka, S.M.3
Costantini, F.4
Rubin, E.M.5
Hofrichter, J.6
Christoph, G.7
Manci, E.8
Culberson, D.9
Factor, S.M.10
Nagel, R.L.11
-
29
-
-
85036444140
-
Creation of viable transgenic/gene-knock-out sickle mice that produce exclusively human sickle hemoglobin (HbS)
-
Pászty C, Brion C, Witkowska E, Mohandas N, Rubin EM: Creation of viable transgenic/gene-knock-out sickle mice that produce exclusively human sickle hemoglobin (HbS) [abstract]. Blood 1996, 88:620a. Reports the creation of mice no longer producing mouse Hb but producing exclusively HbS.
-
(1996)
Blood
, vol.88
-
-
Pászty, C.1
Brion, C.2
Witkowska, E.3
Mohandas, N.4
Rubin, E.M.5
-
30
-
-
85036447817
-
Mouse model of human sickle cell disease
-
Ryan TM, Ciavatta DJ, Townes TM: Mouse model of human sickle cell disease [abstract]. Blood 1996, 88:492a. Reports the creation of mice no longer producing mouse Hb but producing exclusively HbS.
-
(1996)
Blood
, vol.88
-
-
Ryan, T.M.1
Ciavatta, D.J.2
Townes, T.M.3
-
31
-
-
0025224874
-
Mouse β-thalassemia, a model for the membrane defects of erythro-cytes in the human disease
-
Rouyer-Fessard P, Leroy-Viard K, Domenget C, Mrad A, Beuzard Y: Mouse β-thalassemia, a model for the membrane defects of erythro-cytes in the human disease. J Biol Chem 1990, 265:20247-20251.
-
(1990)
J Biol Chem
, vol.265
, pp. 20247-20251
-
-
Rouyer-Fessard, P.1
Leroy-Viard, K.2
Domenget, C.3
Mrad, A.4
Beuzard, Y.5
-
32
-
-
0025239986
-
The role of membrane skeletal-associated α-globin in the pathophysiology of β-thalassemia
-
Sorensen S, Rubin E, Polster H, Mohandas N, Schrier S: The role of membrane skeletal-associated α-globin in the pathophysiology of β-thalassemia. Blood 1990, 75:1333-1336.
-
(1990)
Blood
, vol.75
, pp. 1333-1336
-
-
Sorensen, S.1
Rubin, E.2
Polster, H.3
Mohandas, N.4
Schrier, S.5
-
33
-
-
0026597441
-
Oxidative red blood cell membrane injury in the pathophysiology of severe mouse β-thalassemia
-
Advani R, Rubin E, Mohandas N, Schrier SL: Oxidative red blood cell membrane injury in the pathophysiology of severe mouse β-thalassemia. Blood 1992, 79:1064-1067.
-
(1992)
Blood
, vol.79
, pp. 1064-1067
-
-
Advani, R.1
Rubin, E.2
Mohandas, N.3
Schrier, S.L.4
-
34
-
-
0028362910
-
Defective assembly of membrane proteins in erythroid precursors of β-thalassemic mice
-
Yuan J, Rubin E, Aljurf M, Ma L, Schrier SL: Defective assembly of membrane proteins in erythroid precursors of β-thalassemic mice. Blood 1994, 84:632-637.
-
(1994)
Blood
, vol.84
, pp. 632-637
-
-
Yuan, J.1
Rubin, E.2
Aljurf, M.3
Ma, L.4
Schrier, S.L.5
-
35
-
-
0022457706
-
Cure of murine thalassemia by bone marrow transplantation without eradication of endogenous stem cells
-
Wagemaker G, Visser TP, van Bekkum DW: Cure of murine thalassemia by bone marrow transplantation without eradication of endogenous stem cells. Transplantation 1986, 42:248-251.
-
(1986)
Transplantation
, vol.42
, pp. 248-251
-
-
Wagemaker, G.1
Visser, T.P.2
Van Bekkum, D.W.3
-
36
-
-
0027493909
-
Selective erythroid replacement in murine β-thalassemia using fetal hematopoietic stem cells
-
Bethel CA, Murugesh D, Harrison MR, Mohandas N, Rubin EM: Selective erythroid replacement in murine β-thalassemia using fetal hematopoietic stem cells. Proc Natl Acad Sci U S A 1993, 90:10120-10124.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 10120-10124
-
-
Bethel, C.A.1
Murugesh, D.2
Harrison, M.R.3
Mohandas, N.4
Rubin, E.M.5
-
37
-
-
0025949811
-
Improvement of mouse β-thalassemia by recombinant human erythropoietin
-
Leroy-Viard K, Rouyer-Fessard P, Beuzard Y: Improvement of mouse β-thalassemia by recombinant human erythropoietin. Blood 1991, 78:1596-1602.
-
(1991)
Blood
, vol.78
, pp. 1596-1602
-
-
Leroy-Viard, K.1
Rouyer-Fessard, P.2
Beuzard, Y.3
-
39
-
-
0028232723
-
Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine β-thalassemia
-
Villeval JL, Rouyer-Fessard P, Blumenfeld N, Henri A, Vainchenker W, Beuzard Y: Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine β-thalassemia. Blood 1994, 84:928-933.
-
(1994)
Blood
, vol.84
, pp. 928-933
-
-
Villeval, J.L.1
Rouyer-Fessard, P.2
Blumenfeld, N.3
Henri, A.4
Vainchenker, W.5
Beuzard, Y.6
-
40
-
-
0030063536
-
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a β-thalassemic mouse: A model for human therapy
-
De Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y: Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a β-thalassemic mouse: a model for human therapy. Blood 1996, 87:1188-1195.
-
(1996)
Blood
, vol.87
, pp. 1188-1195
-
-
De Franceschi, L.1
Rouyer-Fessard, P.2
Alper, S.L.3
Jouault, H.4
Brugnara, C.5
Beuzard, Y.6
-
41
-
-
0028106691
-
Retinal and choroidal neovascularization in a transgenic mouse model of sickle cell disease
-
Lutty GA, McLeod DS, Pachnis A, Costantini F, Fabry ME, Nagel RL: Retinal and choroidal neovascularization in a transgenic mouse model of sickle cell disease. Am J Pathol 1994, 145:490-497.
-
(1994)
Am J Pathol
, vol.145
, pp. 490-497
-
-
Lutty, G.A.1
McLeod, D.S.2
Pachnis, A.3
Costantini, F.4
Fabry, M.E.5
Nagel, R.L.6
-
42
-
-
0027973877
-
The transgenic SAD mouse: A model of human sickle cell glomerulopathy
-
De Paepe ME, Trudel M: The transgenic SAD mouse: a model of human sickle cell glomerulopathy. Kidney Int 1994, 46:1337-1345.
-
(1994)
Kidney Int
, vol.46
, pp. 1337-1345
-
-
De Paepe, M.E.1
Trudel, M.2
-
43
-
-
0029812051
-
Renal nitric oxide syntheses in transgenic sickle cell mice
-
Bank N, Aynedjian HS, Qiu JH, Osei SY, Ahima RS, Fabry ME, Nagel RL: Renal nitric oxide syntheses in transgenic sickle cell mice. Kidney Int 1996, 50:184-189.
-
(1996)
Kidney Int
, vol.50
, pp. 184-189
-
-
Bank, N.1
Aynedjian, H.S.2
Qiu, J.H.3
Osei, S.Y.4
Ahima, R.S.5
Fabry, M.E.6
Nagel, R.L.7
-
45
-
-
0028881822
-
In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse
-
Kaul DK, Fabry ME, Costantini F, Rubin EM, Nagel RL: In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest 1995, 96:2845-2853. First in vivo observation (microvideography) of intravascular sickling, erythrocyte-endothelium interaction, and altered microvascular responses to oxygen. This type of approach will be indispensable for studying these phenomena and gaining insight into their roles in vaso-occlusion.
-
(1995)
J Clin Invest
, vol.96
, pp. 2845-2853
-
-
Kaul, D.K.1
Fabry, M.E.2
Costantini, F.3
Rubin, E.M.4
Nagel, R.L.5
-
46
-
-
0029831548
-
Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease
-
Fabry ME, Kennan RP, Pászty C, Costantini F, Rubin EM, Gore JC, Nagel RL: Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease. J Clin Invest 1996, 98:2450-2455.
-
(1996)
J Clin Invest
, vol.98
, pp. 2450-2455
-
-
Fabry, M.E.1
Kennan, R.P.2
Pászty, C.3
Costantini, F.4
Rubin, E.M.5
Gore, J.C.6
Nagel, R.L.7
-
48
-
-
0029082606
-
+ channel by clotrimazole
-
+ channel by clotrimazole. Ann N Y Acad Sci 1995, 763:262-271.
-
(1995)
Ann N Y Acad Sci
, vol.763
, pp. 262-271
-
-
Brugnara, C.1
De Franceschi, L.2
Armsby, C.C.3
Saadane, N.4
Trudel, M.5
Beuzard, Y.6
Rittenhouse, A.7
Rifai, N.8
Platt, O.9
Alper, S.L.10
-
49
-
-
0029793542
-
Modulation of erythrocyte potassium chloride cotransport, potassium content and density by dietary magnesium intake in transgenic SAD mouse
-
De Franceschi L, Beuzard Y, Jouault H, Brugnara C: Modulation of erythrocyte potassium chloride cotransport, potassium content and density by dietary magnesium intake in transgenic SAD mouse. Blood 1996, 88:2738-2744.
-
(1996)
Blood
, vol.88
, pp. 2738-2744
-
-
De Franceschi, L.1
Beuzard, Y.2
Jouault, H.3
Brugnara, C.4
|