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Volumn 4, Issue 2, 1997, Pages 88-93

Transgenic and gene knock-out mouse models of sickle cell anemia and the thalassemias

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEMOGLOBIN H;

EID: 0030958397     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199704020-00003     Document Type: Review
Times cited : (33)

References (49)
  • 1
    • 0029843953 scopus 로고    scopus 로고
    • Thalassemia: A global public health problem
    • Weatherall DJ, Clegg JB: Thalassemia: a global public health problem. Nature Med 1996, 2:847-849.
    • (1996) Nature Med , vol.2 , pp. 847-849
    • Weatherall, D.J.1    Clegg, J.B.2
  • 2
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
    • Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS: Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination. Nature 1985, 317:230-234.
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3    Koralewski, M.A.4    Kucherlapati, R.S.5
  • 3
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR, Capecchi MR: Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987, 51:503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 4
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour SL, Thomas KR, Capecchi MR: Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 1988, 336:348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 6
    • 0024947112 scopus 로고
    • Alpha thalassemia
    • Liebhaber SA: Alpha thalassemia. Hemoglobin 1989, 13:685-731.
    • (1989) Hemoglobin , vol.13 , pp. 685-731
    • Liebhaber, S.A.1
  • 8
    • 0019153312 scopus 로고
    • Linkage of genes for adult α-globin and embryonic α-like globin chains
    • Whitney III JB, Russell ES: Linkage of genes for adult α-globin and embryonic α-like globin chains. Proc Natl Acad Sci U S A 1980, 77:1087-1090.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 1087-1090
    • Whitney III, J.B.1    Russell, E.S.2
  • 9
    • 0019194108 scopus 로고
    • Effects of alpha thalassemia on mouse development
    • Popp RA, Bradshaw BS, Skow LC: Effects of alpha thalassemia on mouse development. Differentiation 1980, 17:205-210.
    • (1980) Differentiation , vol.17 , pp. 205-210
    • Popp, R.A.1    Bradshaw, B.S.2    Skow, L.C.3
  • 10
    • 0028978479 scopus 로고
    • Lethal α-thalassaemia created by gene targeting in mice and its genetic rescue
    • Pászty C, Mohandas N, Stevens ME, Loring JF, Liebhaber SA, Brion CM, Rubin EM: Lethal α-thalassaemia created by gene targeting in mice and its genetic rescue. Nature Genet 1995, 11:33-39. Reports the deletion of both adult α-globin genes and the creation of the first mouse model for severe α-thalassemia. The thalassemic mice are rescued from lethality using a human α-globin transgene. This α-globin deletion is a critical genetic component for the development of murine models of sickle cell disease.
    • (1995) Nature Genet , vol.11 , pp. 33-39
    • Pászty, C.1    Mohandas, N.2    Stevens, M.E.3    Loring, J.F.4    Liebhaber, S.A.5    Brion, C.M.6    Rubin, E.M.7
  • 11
    • 0030993199 scopus 로고    scopus 로고
    • Mouse models for the α- and β-thalassemias: The power of transgenic and gene knock-out approaches
    • Pászty C: Mouse models for the α- and β-thalassemias: the power of transgenic and gene knock-out approaches. Int J Pediatr Hematol/Oncol 1997, 4:75-84.
    • (1997) Int J Pediatr Hematol/Oncol , vol.4 , pp. 75-84
    • Pászty, C.1
  • 12
    • 0029841814 scopus 로고    scopus 로고
    • Inactivation of mouse α-globin gene by homologous recombination: Mouse model of hemoglobin H disease
    • Chang J, Lu RH, Xu SM, Meneses J, Chan K, Pedersen R, Kan YW: Inactivation of mouse α-globin gene by homologous recombination: mouse model of hemoglobin H disease. Blood 1996, 88:1846-1851.
    • (1996) Blood , vol.88 , pp. 1846-1851
    • Chang, J.1    Lu, R.H.2    Xu, S.M.3    Meneses, J.4    Chan, K.5    Pedersen, R.6    Kan, Y.W.7
  • 14
    • 0343597187 scopus 로고
    • Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea
    • Johnson FM, Lewis SE: Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea. Proc Natl Acad Sci U S A 1981, 78:3138-3141.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 3138-3141
    • Johnson, F.M.1    Lewis, S.E.2
  • 17
    • 0027417591 scopus 로고
    • Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene
    • Shehee RW, Oliver P, Smithies O: Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene. Proc Natl Acad Sci U S A 1993, 90:3177-3181.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3177-3181
    • Shehee, R.W.1    Oliver, P.2    Smithies, O.3
  • 18
    • 0029045603 scopus 로고
    • min-globin genes in embryonic stem cells
    • min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A 1995, 92:9259-9263. Reports the deletion of both adult β-globin genes and the creation of a mouse model of β-thalassemia intermedia. This β-globin deletion is a critical genetic component for the development of murine models of sickle cell disease.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9259-9263
    • Ciavatta, D.J.1    Ryan, T.M.2    Farmer, S.C.3    Townes, T.M.4
  • 19
    • 0029589914 scopus 로고
    • o-thalassemia
    • o-thalassemia. Proc Natl Acad Sci U S A 1995, 92:11608-11612. Reports the deletion of both adult β-globin genes and the creation of a mouse model of β-thalassemia intermedia. This β-globin deletion is a critical genetic component for the development of murine models of sickle cell disease.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11608-11612
    • Yang, B.1    Kirby, S.2    Lewis, J.3    Detloff, P.J.4    Maeda, N.5    Smithies, O.6
  • 20
    • 4243891216 scopus 로고    scopus 로고
    • A viable murine model of severe β-thalassemia: Exploration of the role of programmed cell death (PCD) in ineffective erythropoiesis (IE)
    • Pászty C, Mohandas N, Rubin EM, Kuypers F, Yuan J, Ma L, Schrier SL: A viable murine model of severe β-thalassemia: exploration of the role of programmed cell death (PCD) in ineffective erythropoiesis (IE) [abstract]. Blood 1996, 88:152a. Creation of a mouse model that closely mimics β-thalassemia major/Cooley's anemia. The role of apoptosis in the pathophysiology of β-thalassemia is addressed.
    • (1996) Blood , vol.88
    • Pászty, C.1    Mohandas, N.2    Rubin, E.M.3    Kuypers, F.4    Yuan, J.5    Ma, L.6    Schrier, S.L.7
  • 29
    • 85036444140 scopus 로고    scopus 로고
    • Creation of viable transgenic/gene-knock-out sickle mice that produce exclusively human sickle hemoglobin (HbS)
    • Pászty C, Brion C, Witkowska E, Mohandas N, Rubin EM: Creation of viable transgenic/gene-knock-out sickle mice that produce exclusively human sickle hemoglobin (HbS) [abstract]. Blood 1996, 88:620a. Reports the creation of mice no longer producing mouse Hb but producing exclusively HbS.
    • (1996) Blood , vol.88
    • Pászty, C.1    Brion, C.2    Witkowska, E.3    Mohandas, N.4    Rubin, E.M.5
  • 30
    • 85036447817 scopus 로고    scopus 로고
    • Mouse model of human sickle cell disease
    • Ryan TM, Ciavatta DJ, Townes TM: Mouse model of human sickle cell disease [abstract]. Blood 1996, 88:492a. Reports the creation of mice no longer producing mouse Hb but producing exclusively HbS.
    • (1996) Blood , vol.88
    • Ryan, T.M.1    Ciavatta, D.J.2    Townes, T.M.3
  • 31
    • 0025224874 scopus 로고
    • Mouse β-thalassemia, a model for the membrane defects of erythro-cytes in the human disease
    • Rouyer-Fessard P, Leroy-Viard K, Domenget C, Mrad A, Beuzard Y: Mouse β-thalassemia, a model for the membrane defects of erythro-cytes in the human disease. J Biol Chem 1990, 265:20247-20251.
    • (1990) J Biol Chem , vol.265 , pp. 20247-20251
    • Rouyer-Fessard, P.1    Leroy-Viard, K.2    Domenget, C.3    Mrad, A.4    Beuzard, Y.5
  • 32
    • 0025239986 scopus 로고
    • The role of membrane skeletal-associated α-globin in the pathophysiology of β-thalassemia
    • Sorensen S, Rubin E, Polster H, Mohandas N, Schrier S: The role of membrane skeletal-associated α-globin in the pathophysiology of β-thalassemia. Blood 1990, 75:1333-1336.
    • (1990) Blood , vol.75 , pp. 1333-1336
    • Sorensen, S.1    Rubin, E.2    Polster, H.3    Mohandas, N.4    Schrier, S.5
  • 33
    • 0026597441 scopus 로고
    • Oxidative red blood cell membrane injury in the pathophysiology of severe mouse β-thalassemia
    • Advani R, Rubin E, Mohandas N, Schrier SL: Oxidative red blood cell membrane injury in the pathophysiology of severe mouse β-thalassemia. Blood 1992, 79:1064-1067.
    • (1992) Blood , vol.79 , pp. 1064-1067
    • Advani, R.1    Rubin, E.2    Mohandas, N.3    Schrier, S.L.4
  • 34
    • 0028362910 scopus 로고
    • Defective assembly of membrane proteins in erythroid precursors of β-thalassemic mice
    • Yuan J, Rubin E, Aljurf M, Ma L, Schrier SL: Defective assembly of membrane proteins in erythroid precursors of β-thalassemic mice. Blood 1994, 84:632-637.
    • (1994) Blood , vol.84 , pp. 632-637
    • Yuan, J.1    Rubin, E.2    Aljurf, M.3    Ma, L.4    Schrier, S.L.5
  • 35
    • 0022457706 scopus 로고
    • Cure of murine thalassemia by bone marrow transplantation without eradication of endogenous stem cells
    • Wagemaker G, Visser TP, van Bekkum DW: Cure of murine thalassemia by bone marrow transplantation without eradication of endogenous stem cells. Transplantation 1986, 42:248-251.
    • (1986) Transplantation , vol.42 , pp. 248-251
    • Wagemaker, G.1    Visser, T.P.2    Van Bekkum, D.W.3
  • 36
    • 0027493909 scopus 로고
    • Selective erythroid replacement in murine β-thalassemia using fetal hematopoietic stem cells
    • Bethel CA, Murugesh D, Harrison MR, Mohandas N, Rubin EM: Selective erythroid replacement in murine β-thalassemia using fetal hematopoietic stem cells. Proc Natl Acad Sci U S A 1993, 90:10120-10124.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10120-10124
    • Bethel, C.A.1    Murugesh, D.2    Harrison, M.R.3    Mohandas, N.4    Rubin, E.M.5
  • 37
    • 0025949811 scopus 로고
    • Improvement of mouse β-thalassemia by recombinant human erythropoietin
    • Leroy-Viard K, Rouyer-Fessard P, Beuzard Y: Improvement of mouse β-thalassemia by recombinant human erythropoietin. Blood 1991, 78:1596-1602.
    • (1991) Blood , vol.78 , pp. 1596-1602
    • Leroy-Viard, K.1    Rouyer-Fessard, P.2    Beuzard, Y.3
  • 38
    • 0027302773 scopus 로고
    • Improvement of mouse β-thalassemia by hydroxyurea
    • Sauvage C, Rouyer-Fessard P, Beuzard Y: Improvement of mouse β-thalassemia by hydroxyurea. Br J Haematol 1993, 84:492-496.
    • (1993) Br J Haematol , vol.84 , pp. 492-496
    • Sauvage, C.1    Rouyer-Fessard, P.2    Beuzard, Y.3
  • 39
    • 0028232723 scopus 로고
    • Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine β-thalassemia
    • Villeval JL, Rouyer-Fessard P, Blumenfeld N, Henri A, Vainchenker W, Beuzard Y: Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine β-thalassemia. Blood 1994, 84:928-933.
    • (1994) Blood , vol.84 , pp. 928-933
    • Villeval, J.L.1    Rouyer-Fessard, P.2    Blumenfeld, N.3    Henri, A.4    Vainchenker, W.5    Beuzard, Y.6
  • 40
    • 0030063536 scopus 로고    scopus 로고
    • Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a β-thalassemic mouse: A model for human therapy
    • De Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y: Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a β-thalassemic mouse: a model for human therapy. Blood 1996, 87:1188-1195.
    • (1996) Blood , vol.87 , pp. 1188-1195
    • De Franceschi, L.1    Rouyer-Fessard, P.2    Alper, S.L.3    Jouault, H.4    Brugnara, C.5    Beuzard, Y.6
  • 41
    • 0028106691 scopus 로고
    • Retinal and choroidal neovascularization in a transgenic mouse model of sickle cell disease
    • Lutty GA, McLeod DS, Pachnis A, Costantini F, Fabry ME, Nagel RL: Retinal and choroidal neovascularization in a transgenic mouse model of sickle cell disease. Am J Pathol 1994, 145:490-497.
    • (1994) Am J Pathol , vol.145 , pp. 490-497
    • Lutty, G.A.1    McLeod, D.S.2    Pachnis, A.3    Costantini, F.4    Fabry, M.E.5    Nagel, R.L.6
  • 42
    • 0027973877 scopus 로고
    • The transgenic SAD mouse: A model of human sickle cell glomerulopathy
    • De Paepe ME, Trudel M: The transgenic SAD mouse: a model of human sickle cell glomerulopathy. Kidney Int 1994, 46:1337-1345.
    • (1994) Kidney Int , vol.46 , pp. 1337-1345
    • De Paepe, M.E.1    Trudel, M.2
  • 45
    • 0028881822 scopus 로고
    • In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse
    • Kaul DK, Fabry ME, Costantini F, Rubin EM, Nagel RL: In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest 1995, 96:2845-2853. First in vivo observation (microvideography) of intravascular sickling, erythrocyte-endothelium interaction, and altered microvascular responses to oxygen. This type of approach will be indispensable for studying these phenomena and gaining insight into their roles in vaso-occlusion.
    • (1995) J Clin Invest , vol.96 , pp. 2845-2853
    • Kaul, D.K.1    Fabry, M.E.2    Costantini, F.3    Rubin, E.M.4    Nagel, R.L.5
  • 46
    • 0029831548 scopus 로고    scopus 로고
    • Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease
    • Fabry ME, Kennan RP, Pászty C, Costantini F, Rubin EM, Gore JC, Nagel RL: Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease. J Clin Invest 1996, 98:2450-2455.
    • (1996) J Clin Invest , vol.98 , pp. 2450-2455
    • Fabry, M.E.1    Kennan, R.P.2    Pászty, C.3    Costantini, F.4    Rubin, E.M.5    Gore, J.C.6    Nagel, R.L.7
  • 49
    • 0029793542 scopus 로고    scopus 로고
    • Modulation of erythrocyte potassium chloride cotransport, potassium content and density by dietary magnesium intake in transgenic SAD mouse
    • De Franceschi L, Beuzard Y, Jouault H, Brugnara C: Modulation of erythrocyte potassium chloride cotransport, potassium content and density by dietary magnesium intake in transgenic SAD mouse. Blood 1996, 88:2738-2744.
    • (1996) Blood , vol.88 , pp. 2738-2744
    • De Franceschi, L.1    Beuzard, Y.2    Jouault, H.3    Brugnara, C.4


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