-
1
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos B., Corradini E., Xia Y., Faasse S.A., Chen S., Grgurevic L., Knutson M.D., Pietrangelo A., Vukicevic S., Lin H.Y., Babitt J.L. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 2009, 41:482-487.
-
(2009)
Nat. Genet.
, vol.41
, pp. 482-487
-
-
Andriopoulos, B.1
Corradini, E.2
Xia, Y.3
Faasse, S.A.4
Chen, S.5
Grgurevic, L.6
Knutson, M.D.7
Pietrangelo, A.8
Vukicevic, S.9
Lin, H.Y.10
Babitt, J.L.11
-
2
-
-
84873692902
-
Diet-induced changes in Ucp1 expression in bovine adipose tissues
-
Asano H., Yamada T., Hashimoto O., Umemoto T., Sato R., Ohwatari S., Kanamori Y., Terachi T., Funaba M., Matsui T. Diet-induced changes in Ucp1 expression in bovine adipose tissues. Gen. Comp. Endocrinol. 2013, 184:87-92.
-
(2013)
Gen. Comp. Endocrinol.
, vol.184
, pp. 87-92
-
-
Asano, H.1
Yamada, T.2
Hashimoto, O.3
Umemoto, T.4
Sato, R.5
Ohwatari, S.6
Kanamori, Y.7
Terachi, T.8
Funaba, M.9
Matsui, T.10
-
3
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A., Campagna J.A., Chung R.T., Schneyer A.L., Woolf C.J., Andrews N.C., Lin H.Y. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 2006, 38:531-539.
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
Samad, T.A.6
Campagna, J.A.7
Chung, R.T.8
Schneyer, A.L.9
Woolf, C.J.10
Andrews, N.C.11
Lin, H.Y.12
-
4
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
Babitt J.L., Huang F.W., Xia Y., Sidis Y., Andrews N.C., Lin H.Y. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 2007, 117:1933-1939.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
Sidis, Y.4
Andrews, N.C.5
Lin, H.Y.6
-
5
-
-
70349494083
-
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
-
Corradini E., Garuti C., Montosi G., Ventura P., Andriopoulos B., Lin H.Y., Pietrangelo A., Babitt J.L. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology 2009, 137:1489-1497.
-
(2009)
Gastroenterology
, vol.137
, pp. 1489-1497
-
-
Corradini, E.1
Garuti, C.2
Montosi, G.3
Ventura, P.4
Andriopoulos, B.5
Lin, H.Y.6
Pietrangelo, A.7
Babitt, J.L.8
-
6
-
-
78049463632
-
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
-
Corradini E., Schmidt P.J., Meynard D., Garuti C., Montosi G., Chen S., Vukicevic S., Pietrangelo A., Lin H.Y., Babitt J.L. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 2010, 139:1721-1729.
-
(2010)
Gastroenterology
, vol.139
, pp. 1721-1729
-
-
Corradini, E.1
Schmidt, P.J.2
Meynard, D.3
Garuti, C.4
Montosi, G.5
Chen, S.6
Vukicevic, S.7
Pietrangelo, A.8
Lin, H.Y.9
Babitt, J.L.10
-
7
-
-
47949090917
-
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
-
Cuny G.D., Yu P.B., Laha J.K., Xing X., Liu J.F., Lai C.S., Deng D.Y., Sachidanandan C., Bloch K.D., Peterson R.T. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg. Med. Chem. Lett. 2008, 18:4388-4392.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4388-4392
-
-
Cuny, G.D.1
Yu, P.B.2
Laha, J.K.3
Xing, X.4
Liu, J.F.5
Lai, C.S.6
Deng, D.Y.7
Sachidanandan, C.8
Bloch, K.D.9
Peterson, R.T.10
-
8
-
-
34250865977
-
The molecular mechanism of hepcidin-mediated ferroportin down-regulation
-
De Domenico I., Ward D.M., Langelier C., Vaughn M.B., Nemeth E., Sundquist W.I., Ganz T., Musci G., Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol. Biol. Cell 2007, 18:2569-2578.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 2569-2578
-
-
De Domenico, I.1
Ward, D.M.2
Langelier, C.3
Vaughn, M.B.4
Nemeth, E.5
Sundquist, W.I.6
Ganz, T.7
Musci, G.8
Kaplan, J.9
-
9
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
Du X., She E., Gelbart T., Truksa J., Lee P., Xia Y., Khovananth K., Mudd S., Mann N., Moresco E.M., Beutler E., Beutler B. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008, 320:1088-1092.
-
(2008)
Science
, vol.320
, pp. 1088-1092
-
-
Du, X.1
She, E.2
Gelbart, T.3
Truksa, J.4
Lee, P.5
Xia, Y.6
Khovananth, K.7
Mudd, S.8
Mann, N.9
Moresco, E.M.10
Beutler, E.11
Beutler, B.12
-
10
-
-
21344447078
-
Presenilin-1 detection in brain neurons and FOXP3 in peripheral blood mononuclear cells: normalizer gene selection for real time reverse transcriptase pcr using the deltadeltaCt method
-
Duran E.M., Shapshak P., Worley J., Minagar A., Ziegler F., Haliko S., Moleon-Borodowsky I., Haslett P.A. Presenilin-1 detection in brain neurons and FOXP3 in peripheral blood mononuclear cells: normalizer gene selection for real time reverse transcriptase pcr using the deltadeltaCt method. Front. Biosci. 2005, 10:2955-2965.
-
(2005)
Front. Biosci.
, vol.10
, pp. 2955-2965
-
-
Duran, E.M.1
Shapshak, P.2
Worley, J.3
Minagar, A.4
Ziegler, F.5
Haliko, S.6
Moleon-Borodowsky, I.7
Haslett, P.A.8
-
11
-
-
84861355868
-
Hepcidin and iron homeostasis
-
Ganz T., Nemeth E. Hepcidin and iron homeostasis. Biochim. Biophys. Acta 2012, 1823:1434-1443.
-
(2012)
Biochim. Biophys. Acta
, vol.1823
, pp. 1434-1443
-
-
Ganz, T.1
Nemeth, E.2
-
12
-
-
84863531503
-
Inhibition of hepcidin transcription by growth factors
-
Goodnough J.B., Ramos E., Nemeth E., Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology 2012, 56:291-299.
-
(2012)
Hepatology
, vol.56
, pp. 291-299
-
-
Goodnough, J.B.1
Ramos, E.2
Nemeth, E.3
Ganz, T.4
-
13
-
-
84872601036
-
Histone acetylation: molecular mnemonics on the chromatin
-
Gräff J., Tsai L.H. Histone acetylation: molecular mnemonics on the chromatin. Nat. Rev. Neurosci. 2013, 14:97-111.
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 97-111
-
-
Gräff, J.1
Tsai, L.H.2
-
14
-
-
80555135885
-
Transfection of difficult-to-transfect primary mammalian cells
-
Gresch O., Altrogge L. Transfection of difficult-to-transfect primary mammalian cells. Methods Mol. Biol. 2012, 801:65-74.
-
(2012)
Methods Mol. Biol.
, vol.801
, pp. 65-74
-
-
Gresch, O.1
Altrogge, L.2
-
15
-
-
0030765945
-
Smad6 inhibits signalling by the TGF-β superfamily
-
Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K. Smad6 inhibits signalling by the TGF-β superfamily. Nature 1997, 389:622-626.
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
16
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L., Meynard D., Monnier A., Darnaud V., Bouvet R., Wang R.H., Deng C., Vaulont S., Mosser J., Coppin H., Roth M.P. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008, 112:1503-1509.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
Meynard, D.2
Monnier, A.3
Darnaud, V.4
Bouvet, R.5
Wang, R.H.6
Deng, C.7
Vaulont, S.8
Mosser, J.9
Coppin, H.10
Roth, M.P.11
-
17
-
-
0037085441
-
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
-
Korchynskyi O., ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 2002, 277:4883-4891.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4883-4891
-
-
Korchynskyi, O.1
ten Dijke, P.2
-
18
-
-
2042491616
-
Effect of hepcidin on intestinal iron absorption in mice
-
Laftah A.H., Ramesh B., Simpson R.J., Solanky N., Bahram S., Schümann K., Debnam E.S., Srai S.K. Effect of hepcidin on intestinal iron absorption in mice. Blood 2004, 103:3940-3944.
-
(2004)
Blood
, vol.103
, pp. 3940-3944
-
-
Laftah, A.H.1
Ramesh, B.2
Simpson, R.J.3
Solanky, N.4
Bahram, S.5
Schümann, K.6
Debnam, E.S.7
Srai, S.K.8
-
19
-
-
66149145303
-
Regulation of hepcidin and iron-overload disease
-
Lee P.L., Beutler E. Regulation of hepcidin and iron-overload disease. Annu. Rev. Pathol. 2009, 4:489-515.
-
(2009)
Annu. Rev. Pathol.
, vol.4
, pp. 489-515
-
-
Lee, P.L.1
Beutler, E.2
-
20
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D., Kautz L., Darnaud V., Canonne-Hergaux F., Coppin H., Roth M.P. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 2009, 41:478-481.
-
(2009)
Nat. Genet.
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
Roth, M.P.6
-
21
-
-
79960674973
-
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
-
Meynard D., Vaja V., Sun C.C., Corradini E., Chen S., López-Otín C., Grgurevic L., Hong C.C., Stirnberg M., Gütschow M., Vukicevic S., Babitt J.L., Lin H.Y. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 2011, 118:747-756.
-
(2011)
Blood
, vol.118
, pp. 747-756
-
-
Meynard, D.1
Vaja, V.2
Sun, C.C.3
Corradini, E.4
Chen, S.5
López-Otín, C.6
Grgurevic, L.7
Hong, C.C.8
Stirnberg, M.9
Gütschow, M.10
Vukicevic, S.11
Babitt, J.L.12
Lin, H.Y.13
-
22
-
-
77950979752
-
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
-
Mleczko-Sanecka K., Casanovas G., Ragab A., Breitkopf K., Müller A., Boutros M., Dooley S., Hentze M.W., Muckenthaler M.U. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2010, 115:2657-2665.
-
(2010)
Blood
, vol.115
, pp. 2657-2665
-
-
Mleczko-Sanecka, K.1
Casanovas, G.2
Ragab, A.3
Breitkopf, K.4
Müller, A.5
Boutros, M.6
Dooley, S.7
Hentze, M.W.8
Muckenthaler, M.U.9
-
23
-
-
45549096257
-
Fine tuning of hepcidin expression by positive and negative regulators
-
Muckenthaler M.U. Fine tuning of hepcidin expression by positive and negative regulators. Cell Metab. 2008, 8:1-3.
-
(2008)
Cell Metab.
, vol.8
, pp. 1-3
-
-
Muckenthaler, M.U.1
-
24
-
-
63349097519
-
Receptor expression modulates the specificity of transforming growth factor-β signaling pathways
-
Murakami M., Kawachi H., Ogawa K., Nishino Y., Funaba M. Receptor expression modulates the specificity of transforming growth factor-β signaling pathways. Genes Cells 2009, 14:469-482.
-
(2009)
Genes Cells
, vol.14
, pp. 469-482
-
-
Murakami, M.1
Kawachi, H.2
Ogawa, K.3
Nishino, Y.4
Funaba, M.5
-
25
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.B.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
26
-
-
84875627646
-
Prohepcidin binds to the HAMP promoter and autoregulates its own expression
-
Pandur E., Sipos K., Grama L., Nagy J., Poór V.S., Sétáló G., Miseta A., Fekete Z. Prohepcidin binds to the HAMP promoter and autoregulates its own expression. Biochem. J. 2013, 451:301-311.
-
(2013)
Biochem. J.
, vol.451
, pp. 301-311
-
-
Pandur, E.1
Sipos, K.2
Grama, L.3
Nagy, J.4
Poór, V.S.5
Sétáló, G.6
Miseta, A.7
Fekete, Z.8
-
27
-
-
84860634625
-
Hepcidin expression in iron overload diseases is variably modulated by circulating factors
-
Ravasi G., Pelucchi S., Trombini P., Mariani R., Tomosugi N., Modignani G.L., Pozzi M., Nemeth E., Ganz T., Hayashi H., Barisani D., Piperno A. Hepcidin expression in iron overload diseases is variably modulated by circulating factors. PLoS One 2012, 7:e36425.
-
(2012)
PLoS One
, vol.7
-
-
Ravasi, G.1
Pelucchi, S.2
Trombini, P.3
Mariani, R.4
Tomosugi, N.5
Modignani, G.L.6
Pozzi, M.7
Nemeth, E.8
Ganz, T.9
Hayashi, H.10
Barisani, D.11
Piperno, A.12
-
28
-
-
0141864365
-
Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis
-
Rebbapragada A., Benchabane H., Wrana J.L., Celeste A.J., Attisano L. Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 2003, 23:7230-7242.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7230-7242
-
-
Rebbapragada, A.1
Benchabane, H.2
Wrana, J.L.3
Celeste, A.J.4
Attisano, L.5
-
29
-
-
80052647221
-
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
-
Theurl I., Schroll A., Sonnweber T., Nairz M., Theurl M., Willenbacher W., Eller K., Wolf D., Seifert M., Sun C.C., Babitt J.L., Hong C.C., Menhall T., Gearing P., Lin H.Y., Weiss G. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood 2011, 118:4977-4984.
-
(2011)
Blood
, vol.118
, pp. 4977-4984
-
-
Theurl, I.1
Schroll, A.2
Sonnweber, T.3
Nairz, M.4
Theurl, M.5
Willenbacher, W.6
Eller, K.7
Wolf, D.8
Seifert, M.9
Sun, C.C.10
Babitt, J.L.11
Hong, C.C.12
Menhall, T.13
Gearing, P.14
Lin, H.Y.15
Weiss, G.16
-
30
-
-
34548559118
-
Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9
-
Truksa J., Peng H., Lee P., Beutler E. Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9. Br. J. Haematol. 2007, 139:138-147.
-
(2007)
Br. J. Haematol.
, vol.139
, pp. 138-147
-
-
Truksa, J.1
Peng, H.2
Lee, P.3
Beutler, E.4
-
31
-
-
33745898241
-
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
-
Truksa J., Peng H., Lee P., Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:10289-10293.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 10289-10293
-
-
Truksa, J.1
Peng, H.2
Lee, P.3
Beutler, E.4
-
32
-
-
60249095353
-
Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
-
Truksa J., Lee P., Beutler E. Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 2009, 113:688-695.
-
(2009)
Blood
, vol.113
, pp. 688-695
-
-
Truksa, J.1
Lee, P.2
Beutler, E.3
-
33
-
-
0027421430
-
Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome
-
Tsubuki S., Kawasaki H., Saito Y., Miyashita N., Inomata M., Kawashima S. Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome. Biochem. Biophys. Res. Commun. 1993, 196:1195-1201.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.196
, pp. 1195-1201
-
-
Tsubuki, S.1
Kawasaki, H.2
Saito, Y.3
Miyashita, N.4
Inomata, M.5
Kawashima, S.6
-
34
-
-
78649689822
-
Use of RNAlater in fluorescence-activated cell sorting (FACS) reduces the fluorescence from GFP but not from DsRed
-
Zaitoun I., Erickson C.S., Schell K., Epstein M.L. Use of RNAlater in fluorescence-activated cell sorting (FACS) reduces the fluorescence from GFP but not from DsRed. BMC Res. Notes 2010, 3:328.
-
(2010)
BMC Res. Notes
, vol.3
, pp. 328
-
-
Zaitoun, I.1
Erickson, C.S.2
Schell, K.3
Epstein, M.L.4
|