Hepcidin expression in iron overload diseases is variably modulated by circulating factors

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Ravasi, Giulia ^a   Pelucchi, Sara ^a   Trombini, Paola ^b   Mariani, Raffaella ^b   Tomosugi, Naohisa ^c   Modignani, Giulia Litta ^a   Pozzi, Matteo ^a   Nemeth, Elizabeth ^d   Ganz, Tomas ^d   Hayashi, Hisao ^c   Barisani, Donatella ^a   Piperno, Alberto ^a,b,e  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Consortium of Human Molecular Genetics ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN; HEPCIDIN; MESSENGER RNA; ANTIMICROBIAL CATIONIC PEPTIDE; CYTOKINE; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; HOLOTRANSFERRIN; IRON; MEMBRANE PROTEIN; TRANSFERRIN;

ADULT; ARTICLE; CELL LINE; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; FEMALE; GENE MUTATION; GLUCOSE BLOOD LEVEL; HEMOCHROMATOSIS; HETEROZYGOTE DETECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IRON OVERLOAD; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; THALASSEMIA; UPREGULATION; AGED; BETA THALASSEMIA; BIOPSY; BLOOD; CELL STRAIN HEPG2; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY; URINE;

ADULT; AGED; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-THALASSEMIA; BIOPSY; CYTOKINES; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HEP G2 CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; IRON OVERLOAD; LIVER; MEMBRANE PROTEINS; MIDDLE AGED; RNA, MESSENGER; TRANSFERRIN;

EID: 84860634625     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036425     Document Type: Article

References (37)

1. Piperno A, Mariani R, Trombini P, Girelli D, (2009) Hepcidin modulation in human diseases: from research to clinic. World J Gastroenterol 15: 538-551.
2. Ganz T, (2011) Hepcidin and iron regulation, 10 years later. Blood 117: 4425-4433.
3. Ginzburg Y, Rivella S, (2011) beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 118: 4321-4330.
4. Camaschella C, Silvestri L, (2011) Molecular mechanisms regulating hepcidin revealed by hepcidin disorders. ScientificWorldJournal 11: 1357-1366.
5. Pietrangelo A, (2010) Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139: 393-408, 408 e391-392.
6. Pantopoulos K, (2008) Function of the hemochromatosis protein HFE: Lessons from animal models. World J Gastroenterol 14: 6893-6901.
7. Riva A, Trombini P, Mariani R, Salvioni A, Coletti S, et al. (2008) Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome. World J Gastroenterol 14: 4745-4752.
8. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, et al. (2008) Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol 49: 123-133.
9. Ruivard M, Laine F, Ganz T, Olbina G, Westerman M, et al. (2009) Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol 50: 1219-1225.
10. Detivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, et al. (2005) Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 106: 746-748.
11. Bekri S, Gual P, Anty R, Luciani N, Dahman M, et al. (2006) Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 131: 788-796.
12. (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106: 3143-3421.
13. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313-1321.
14. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C, (2005) Hepcidin is decreased in TFR2 hemochromatosis. Blood 105: 1803-1806.
15. Murao N, Ishigai M, Yasuno H, Shimonaka Y, Aso Y, (2007) Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up. Rapid Commun Mass Spectrom 21: 4033-4038.
16. Murphy AT, Witcher DR, Luan P, Wroblewski VJ, (2007) Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 110: 1048-1054.
17. Kaneko Y, Miyajima H, Piperno A, Tomosugi N, Hayashi H, et al. (2010) Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol 45: 1163-1171.
18. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, et al. (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22: 696-699.
19. Deugnier YM, Loreal O, Turlin B, Guyader D, Jouanolle H, et al. (1992) Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 102: 2050-2059.
20. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
21. Weizer-Stern O, Adamsky K, Amariglio N, Levin C, Koren A, et al. (2006) Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol 135: 129-138.
22. Vecchi C, Montosi G, Pietrangelo A, (2010) Huh-7: a human "hemochromatotic" cell line. Hepatology 51: 654-659.
23. Kattamis A, Papassotiriou I, Palaiologou D, Apostolakou F, Galani A, et al. (2006) The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 91: 809-812.
24. Tsochatzis E, Papatheodoridis GV, Koliaraki V, Hadziyannis E, Kafiri G, et al. (2010) Serum hepcidin levels are related to the severity of liver histological lesions in chronic hepatitis C. J Viral Hepat 17: 800-806.
25. Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, et al. (2008) Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol 49: 702-710.
26. Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, et al. (2011) Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver Int 31: 994-1000.
27. Mendler MH, Kanel G, Govindarajan S, (2005) Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int 25: 294-304.
28. Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, et al. (2004) Effects of venesections and restricted diet in patients with the insulin-resistance hepatic iron overload syndrome. Liver Int 24: 471-476.
29. Traglia M, Girelli D, Biino G, Campostrini N, Corbella M, et al. (2011) Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations. J Med Genet 48: 629-634.
30. Moirand R, Mortaji AM, Loreal O, Paillard F, Brissot P, et al. (1997) A new syndrome of liver iron overload with normal transferrin saturation. Lancet 349: 95-97.
31. Trombini P, Piperno A, (2007) Ferritin, metabolic syndrome and NAFLD: elective attractions and dangerous liaisons. J Hepatol 46: 549-552.
32. Hentze MW, Muckenthaler MU, Galy B, Camaschella C, (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142: 24-38.
33. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, et al. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 13: 1096-1101.
34. Kemna EH, Kartikasari AE, van Tits LJ, Pickkers P, Tjalsma H, et al. (2008) Regulation of hepcidin: insights from biochemical analyses on human serum samples. Blood Cells Mol Dis 40: 339-346.
35. Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, et al. (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114: 181-186.
36. Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, et al. (2010) Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 117: 2953-2959.
37. Theurl I, Finkenstedt A, Schroll A, Nairz M, Sonnweber T, et al. (2010) Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia. Br J Haematol 148: 449-455.