Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 6, 2014, Pages 1042-1049

  Hara, Hirokazu ^a   Ikeda, Ryoko ^a   Ninomiya, Masayuki ^b   Kamiya, Tetsuro ^a   Koketsu, Mamoru ^b   Adachi, Tetsuo ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Inducible NO synthase; Interferon ; Lipopolysaccharide; Microglia; Nitric oxide (NO); Signal transduction and activator of transcription 1 (STAT1)

Indexed keywords

CHALCONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; CHALCONE; NOS2 PROTEIN, RAT; STAT1 PROTEIN, RAT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRASSICA RAPA; CELL PROLIFERATION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CULTURE TECHNIQUE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; SYNTHESIS;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; CHALCONE; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; STAT1 TRANSCRIPTION FACTOR;

EID: 84901824109     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b14-00116     Document Type: Article

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