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Volumn 33, Issue 22, 2014, Pages 2888-2897

LXRα-mediated downregulation of FOXM1 suppresses the proliferation of hepatocellular carcinoma cells

Author keywords

cell cycle; cell proliferation; FOXM1; HCC; LXRs

Indexed keywords

CYCLIN B1; CYCLIN D1; FORKHEAD BOX M1; FORKHEAD TRANSCRIPTION FACTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; UNCLASSIFIED DRUG;

EID: 84901819312     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.250     Document Type: Article
Times cited : (57)

References (50)
  • 1
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • DOI 10.1146/annurev.cellbio.16.1.459
    • Repa JJ, Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 2000; 16: 459-481. (Pubitemid 32037514)
    • (2000) Annual Review of Cell and Developmental Biology , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 3
    • 77954643389 scopus 로고    scopus 로고
    • Recent progress in liver X receptor-selective modulators
    • Ratni H, Wright MB. Recent progress in liver X receptor-selective modulators. Curr Opin Drug Discov Dev 2010; 13: 403-413.
    • (2010) Curr Opin Drug Discov Dev , vol.13 , pp. 403-413
    • Ratni, H.1    Wright, M.B.2
  • 5
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    • Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000; 289: 1524-1529.
    • (2000) Science , vol.289 , pp. 1524-1529
    • Repa, J.J.1    Turley, S.D.2    Lobaccaro, J.A.3    Medina, J.4    Li, L.5    Lustig, K.6
  • 6
    • 0347034082 scopus 로고    scopus 로고
    • Characterization of the human ABCG1 gene. Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
    • DOI 10.1074/jbc.M105863200
    • Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N et al. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 2001; 276: 39438-39447. (Pubitemid 37371322)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.42 , pp. 39438-39447
    • Kennedy, M.A.1    Venkateswaran, A.2    Tarr, P.T.3    Xenarios, I.4    Kudoh, J.5    Shimizu, N.6    Edwards, P.A.7
  • 8
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • DOI 10.1016/S0092-8674(00)81432-4
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998; 93: 693-704. (Pubitemid 28257577)
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 9
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β
    • DOI 10.1074/jbc.M109927200
    • Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 2002; 277: 18793-18800. (Pubitemid 34952438)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.5    Mangelsdorf, D.J.6
  • 10
    • 76649100139 scopus 로고    scopus 로고
    • Liver X receptor in cholesterol metabolism
    • Zhao C, Dahlman-Wright K. Liver X receptor in cholesterol metabolism. J Endocrinol 2010; 204: 233-240.
    • (2010) J Endocrinol , vol.204 , pp. 233-240
    • Zhao, C.1    Dahlman-Wright, K.2
  • 11
    • 77958533169 scopus 로고    scopus 로고
    • Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines
    • Chuu CP, Lin HP. Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. Anticancer Res 2010; 30: 3643-3648.
    • (2010) Anticancer Res , vol.30 , pp. 3643-3648
    • Chuu, C.P.1    Lin, H.P.2
  • 12
    • 70749157037 scopus 로고    scopus 로고
    • Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
    • Scoles DR, Xu X, Wang H, Tran H, Taylor-Harding B, Li A et al. Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Gynecol Oncol 2010; 116: 109-116.
    • (2010) Gynecol Oncol , vol.116 , pp. 109-116
    • Scoles, D.R.1    Xu, X.2    Wang, H.3    Tran, H.4    Taylor-Harding, B.5    Li, A.6
  • 13
    • 33746176754 scopus 로고    scopus 로고
    • Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
    • DOI 10.1158/0008-5472.CAN-06-0632
    • Chuu CP, Hiipakka RA, Kokontis JM, Fukuchi J, Chen RY, Liao S. Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Cancer Res 2006; 66: 6482-6486. (Pubitemid 44085600)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6482-6486
    • Chuu, C.-P.1    Hiipakka, R.A.2    Kokontis, J.M.3    Fukuchi, J.4    Chen, R.-Y.5    Liao, S.6
  • 14
    • 81055137232 scopus 로고    scopus 로고
    • FOXM1: From cancer initiation to progression and treatment
    • Koo CY, Muir KW, Lam EW. FOXM1: from cancer initiation to progression and treatment. Biochim Biophys Acta 2012; 1819: 28-37.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 28-37
    • Koo, C.Y.1    Muir, K.W.2    Lam, E.W.3
  • 16
    • 0031437834 scopus 로고    scopus 로고
    • The winged-helix transcription factor trident is expressed in actively dividing lymphocytes
    • Korver W, Roose J, Wilson A, Clevers H. The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. Immunobiology 1997; 198: 157-161. (Pubitemid 28021391)
    • (1997) Immunobiology , vol.198 , Issue.1-3 , pp. 157-161
    • Korver, W.1    Roose, J.2    Wilson, A.3    Clevers, H.4
  • 17
    • 79954518901 scopus 로고    scopus 로고
    • Overexpression of forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma
    • Sun HC, Li M, Lu JL, Yan DW, Zhou CZ, Fan JW et al. Overexpression of forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma. Oncol Rep 2011; 25: 1533-1539.
    • (2011) Oncol Rep , vol.25 , pp. 1533-1539
    • Sun, H.C.1    Li, M.2    Lu, J.L.3    Yan, D.W.4    Zhou, C.Z.5    Fan, J.W.6
  • 18
    • 84862793174 scopus 로고    scopus 로고
    • Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma
    • Xia JT, Wang H, Liang LJ, Peng BG, Wu ZF, Chen LZ et al. Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma. Pancreas 2012; 41: 629-635.
    • (2012) Pancreas , vol.41 , pp. 629-635
    • Xia, J.T.1    Wang, H.2    Liang, L.J.3    Peng, B.G.4    Wu, Z.F.5    Chen, L.Z.6
  • 20
    • 66349107985 scopus 로고    scopus 로고
    • Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC
    • Calvisi DF, Pinna F, Ladu S, Pellegrino R, Simile MM, Frau M et al. Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. Gut 2009; 58: 679-687.
    • (2009) Gut , vol.58 , pp. 679-687
    • Calvisi, D.F.1    Pinna, F.2    Ladu, S.3    Pellegrino, R.4    Simile, M.M.5    Frau, M.6
  • 21
    • 79955463277 scopus 로고    scopus 로고
    • FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria
    • Sun H, Teng M, Liu J, Jin D, Wu J, Yan D et al. FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria. Cancer Lett 2011; 306: 214-222.
    • (2011) Cancer Lett , vol.306 , pp. 214-222
    • Sun, H.1    Teng, M.2    Liu, J.3    Jin, D.4    Wu, J.5    Yan, D.6
  • 23
    • 77749270481 scopus 로고    scopus 로고
    • Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro
    • Liu C, Wu QF, Tai MH, Liu D, Lei L, Wang RT et al. Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro. Acta Pharmacol Sin 2010; 31: 361-366.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 361-366
    • Liu, C.1    Wu, Q.F.2    Tai, M.H.3    Liu, D.4    Lei, L.5    Wang, R.T.6
  • 24
    • 84859821303 scopus 로고    scopus 로고
    • Adenovirus-mediated RNA interference targeting FOXM1 transcription factor suppresses cell proliferation and tumor growth of nasopharyngeal carcinoma
    • Chen H, Yang C, Yu L, Xie L, Hu J, Zeng L et al. Adenovirus-mediated RNA interference targeting FOXM1 transcription factor suppresses cell proliferation and tumor growth of nasopharyngeal carcinoma. J Gene Med 2012; 14: 231-240.
    • (2012) J Gene Med , vol.14 , pp. 231-240
    • Chen, H.1    Yang, C.2    Yu, L.3    Xie, L.4    Hu, J.5    Zeng, L.6
  • 25
    • 79951831756 scopus 로고    scopus 로고
    • Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy
    • Uddin S, Ahmed M, Hussain A, Abubaker J, Al-Sanea N, Abdul Jabbar A et al. Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol 2011; 178: 537-547.
    • (2011) Am J Pathol , vol.178 , pp. 537-547
    • Uddin, S.1    Ahmed, M.2    Hussain, A.3    Abubaker, J.4    Al-Sanea, N.5    Abdul Jabbar, A.6
  • 26
    • 77950616155 scopus 로고    scopus 로고
    • Farnesold X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription
    • Huang WD, Chen WD, Wang YD, Zhang LS, Shiah S, Wang MH et al. Farnesold X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 2010; 51: 953-962.
    • (2010) Hepatology , vol.51 , pp. 953-962
    • Huang, W.D.1    Chen, W.D.2    Wang, Y.D.3    Zhang, L.S.4    Shiah, S.5    Wang, M.H.6
  • 27
    • 77952675958 scopus 로고    scopus 로고
    • FOXM1 is a transcriptional target of ER alpha and has a critical role in breast cancer endocrine sensitivity and resistance
    • Lam EWF, Millour J, Constantinidou D, Stavropoulou AV, Wilson MSC, Myatt SS et al. FOXM1 is a transcriptional target of ER alpha and has a critical role in breast cancer endocrine sensitivity and resistance. Oncogene 2010; 29: 2983-2995.
    • (2010) Oncogene , vol.29 , pp. 2983-2995
    • Ewf, L.1    Millour, J.2    Constantinidou, D.3    Stavropoulou, A.V.4    Msc, W.5    Myatt, S.S.6
  • 28
    • 34548675597 scopus 로고    scopus 로고
    • Modulation of liver X receptor signaling as novel therapy for prostate cancer
    • DOI 10.1007/s11373-007-9160-8
    • Chuu CP, Kokontis JM, Hiipakka RA, Liao S. Modulation of liver X receptor signaling as novel therapy for prostate cancer. J Biomed Sci 2007; 14: 543-553. (Pubitemid 47414761)
    • (2007) Journal of Biomedical Science , vol.14 , Issue.5 , pp. 543-553
    • Chuu, C.-P.1    Kokontis, J.M.2    Hiipakka, R.A.3    Liao, S.4
  • 29
    • 77952242043 scopus 로고    scopus 로고
    • Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells
    • Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B et al. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene 2010; 29: 2712-2723.
    • (2010) Oncogene , vol.29 , pp. 2712-2723
    • Pommier, A.J.1    Alves, G.2    Viennois, E.3    Bernard, S.4    Communal, Y.5    Sion, B.6
  • 32
    • 21644487430 scopus 로고    scopus 로고
    • Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries
    • Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J, Fishbein MC et al. Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res 2004; 95: e110-e123.
    • (2004) Circ Res , vol.95
    • Blaschke, F.1    Leppanen, O.2    Takata, Y.3    Caglayan, E.4    Liu, J.5    Fishbein, M.C.6
  • 33
    • 79955030449 scopus 로고    scopus 로고
    • Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4
    • Pascual-Garcia M, Carbo JM, Leon T, Matalonga J, Out R, Van Berkel T et al. Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. J Immunol 2011; 186: 4656-4667.
    • (2011) J Immunol , vol.186 , pp. 4656-4667
    • Pascual-Garcia, M.1    Carbo, J.M.2    Leon, T.3    Matalonga, J.4    Out, R.5    Van Berkel, T.6
  • 34
    • 0037113939 scopus 로고    scopus 로고
    • Kip1 protein levels and increased Cdc25B expression
    • DOI 10.1074/jbc.M207510200
    • Wang X, Krupczak-Hollis K, Tan Y, Dennewitz MB, Adami GR, Costa RH. Increased hepatic forkhead box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression. J Biol Chem 2002; 277: 44310-44316. (Pubitemid 36157865)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 44310-44316
    • Wang, X.1    Krupczak-Hollis, K.2    Tan, Y.3    Dennewitz, M.B.4    Adami, G.R.5    Costa, R.H.6
  • 35
    • 0033506486 scopus 로고    scopus 로고
    • Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase
    • Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 1999; 19: 8570-8580. (Pubitemid 30414050)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.12 , pp. 8570-8580
    • Ye, H.1    Holterman, A.X.2    Yoo, K.W.3    Franks, R.R.4    Costa, R.H.5
  • 36
    • 79851492288 scopus 로고    scopus 로고
    • Multiple faces of FoxM1 transcription factor: Lessons from transgenic mouse models
    • Kalin TV, Ustiyan V, Kalinichenko VV. Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models. Cell Cycle 2011; 10: 396-405.
    • (2011) Cell Cycle , vol.10 , pp. 396-405
    • Kalin, T.V.1    Ustiyan, V.2    Kalinichenko, V.V.3
  • 37
    • 15944392073 scopus 로고    scopus 로고
    • Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells
    • Li Y, Hong X, Hussain M, Sarkar SH, Li R, Sarkar FH. Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. Mol Cancer Ther 2005; 4: 389-398. (Pubitemid 40443924)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.3 , pp. 389-398
    • Li, Y.1    Hong, X.2    Hussain, M.3    Sarkar, S.H.4    Li, R.5    Sarkar, F.H.6
  • 39
    • 68949154568 scopus 로고    scopus 로고
    • FoxM1 is a general target for proteasome inhibitors
    • Bhat UG, Halasi M, Gartel AL. FoxM1 is a general target for proteasome inhibitors. PLoS One 2009; 4: e6593.
    • (2009) PLoS One , vol.4
    • Bhat, U.G.1    Halasi, M.2    Gartel, A.L.3
  • 42
    • 84862687669 scopus 로고    scopus 로고
    • Liver X receptor biology and pharmacology: New pathways, challenges and opportunities
    • Jakobsson T, Treuter E, Gustafsson JA, Steffensen KR. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol Sci 2012; 33: 394-404.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 394-404
    • Jakobsson, T.1    Treuter, E.2    Gustafsson, J.A.3    Steffensen, K.R.4
  • 43
    • 20544442736 scopus 로고    scopus 로고
    • The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor β and the liver X receptor
    • DOI 10.1042/BJ20041556
    • Beaudet MJ, Desrochers M, Lachaud AA, Anderson A. The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta and the liver X receptor. Biochem J 2005; 388: 407-418. (Pubitemid 40839917)
    • (2005) Biochemical Journal , vol.388 , Issue.2 , pp. 407-418
    • Beaudet, M.-J.1    Desrochers, M.2    Lachaud, A.A.3    Anderson, A.4
  • 44
    • 0036915379 scopus 로고    scopus 로고
    • Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
    • DOI 10.1194/jlr.C200014-JLR200
    • Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. J Lipid Res 2002; 43: 2037-2041. (Pubitemid 35471069)
    • (2002) Journal of Lipid Research , vol.43 , Issue.12 , pp. 2037-2041
    • Mak, P.A.1    Kast-Woelbern, H.R.2    Anisfeld, A.M.3    Edwards, P.A.4
  • 46
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 2008; 38: 1122-1129.
    • (2008) Hepatol Res , vol.38 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5    Yamashita, N.6
  • 47
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and hepatic lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR
    • DOI 10.1074/jbc.M605023200
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007; 282: 743-751. (Pubitemid 47076632)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.-Y.1    Repa, J.J.2
  • 48
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000; 14: 2819-2830.
    • (2000) Genes Dev , vol.14 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3    Bashmakov, Y.4    Lobaccaro, J.M.5    Shimomura, I.6
  • 49
    • 78650043469 scopus 로고    scopus 로고
    • Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity
    • Kim KH, Lee GY, Kim JI, Ham M, Won Lee J, Kim JB. Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity. J Lipid Res 2010; 51: 3425-3433.
    • (2010) J Lipid Res , vol.51 , pp. 3425-3433
    • Kim, K.H.1    Lee, G.Y.2    Kim, J.I.3    Ham, M.4    Won Lee, J.5    Kim, J.B.6
  • 50
    • 33644861794 scopus 로고    scopus 로고
    • Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells
    • He F, Li J, Mu Y, Kuruba R, Ma Z, Wilson A et al. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circ Res 2006; 98: 192-199.
    • (2006) Circ Res , vol.98 , pp. 192-199
    • He, F.1    Li, J.2    Mu, Y.3    Kuruba, R.4    Ma, Z.5    Wilson, A.6


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