Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model

Technology and Health Care

Volumn 22, Issue 1, 2014, Pages 37-51

  Gill, Sarah Louise ^a,b   O'neill, Hugh ^a,b   Mccoy, Ryan J ^a,b   Logeswaran, Suhanniya ^a   O'brien, Fiona ^a   Stanton, Alice ^a   Kelly, Helena ^a   Duffy, Garry P ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

cardiomyocytes; heart failure; microbubbles; microRNA; ultrasound

Indexed keywords

LIPOSOME; MICRORNA; MIRN133 MICRORNA, MOUSE;

ANIMAL; CARDIOMEGALY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ECHOGRAPHY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE THERAPY; GENETIC TRANSFECTION; HEART MUSCLE CELL; IN VITRO STUDY; MICROBUBBLE; MOUSE; PROCEDURES; THERAPEUTIC USE;

ANIMALS; CARDIOMEGALY; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; GENETIC THERAPY; IN VITRO TECHNIQUES; LIPOSOMES; MICE; MICROBUBBLES; MICRORNAS; MICROSCOPY, FLUORESCENCE; MYOCYTES, CARDIAC; TRANSFECTION;

EID: 84901819262     PISSN: 09287329     EISSN: None     Source Type: Journal    
DOI: 10.3233/THC-130772     Document Type: Article

References (33)

1. Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., et al. Heart Disease and Stroke Statistics - 2007 Update. Circulation 115 (2007) e69-e171
2. Lathrop, D. A. & Skarlatos, S. Current NHLBI perspectives on translational heart failure research. Journal of Molecular and Cellular Cardiology 51 (2011) 441-443
3. Plump, A. & Madwed, J. Heart failure drug discovery: Scarred or ready for remodeling?. Journal of Molecular and Cellular Cardiology 51 (2011) 444-448
4. Massie, B. M. Novel targets for the treatment of heart failure: Perspectives from a heart failure clinician and trialist. Journal of Molecular and Cellular Cardiology 51 (2011) 438-440
5. Montgomery, R. L. & van Rooij, E. MicroRNA regulation as a therapeutic strategy for cardiovascular disease. Curr Drug Targets 11 (2010) 936-942
6. Hullinger, T. G.,Montgomery, R. L., Seto, A. G., Dickinson, B. A., Semus, H.M., Lynch, J. M., Dalby, C.M., Robinson, K., et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ. Res. 110 (2012) 71-81
7. Montgomery, R. L., Hullinger, T. G., Semus, H. M., Dickinson, B. A., Seto, A. G., Lynch, J. M., Stack, C., Latimer, P. A., et al. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 124 (2011) 1537-1547
8. Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P., Bang, M-L., Segnalini, P., et al. MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 13 (2007) 613-618
9. van Rooij, E., Marshall, W. S. & Olson, E. N. Toward microRNA-based therapeutics for heart disease: The sense in antisense. Circ. Res. 103 (2008) 919-928
10. Mayer, C. R. & Bekeredjian, R. Ultrasonic gene and drug delivery to the cardiovascular system. Adv. Drug Deliv. Rev. 60 (2008) 1177-1192
11. Otani, K., Yamahara, K., Ohnishi, S., Obata, H., Kitamura, S. & Nagaya, N. Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles. J Control Release 133 (2009) 146-153
12. Phillips, L. C., Klibanov, A. L., Wamhoff, B. R. & Hossack, J. A. Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery. Ultrasound Med Biol 36 (2010) 1470-1480
13. O'Reilly, M. A., Waspe, A. C., Ganguly, M. & Hynynen, K. Focused-ultrasound disruption of the blood-brain barrier using closely-Timed short pulses: Influence of sonication parameters and injection rate. Ultrasound Med Biol 37 (2011) 587-594
14. Rubiera, M., Ribo, M., Delgado-Mederos, R., Santamarina, E., Maisterra, O., Delgado, P., Montaner, J., Alvarez-Sabín, J., et al. Do Bubble Characteristics Affect Recanalization in Stroke Patients Treated with Microbubble-Enhanced Sonothrombolysis?. Ultrasound in Medicine & Biology 34 (2008) 1573-1577
15. Hernot, S. & Klibanov, A. L. Microbubbles in ultrasound-Triggered drug and gene delivery. Adv. Drug Deliv. Rev. 60 (2008) 1153-1166
16. Unger, E. C., Porter, T., Culp, W., Labell, R., Matsunaga, T. & Zutshi, R. Therapeutic applications of lipid-coated microbubbles. Adv. Drug Deliv. Rev. 56 (2004) 1291-1314
17. Lum, A. F. H., Borden, M. A., Dayton, P. A., Kruse, D. E., Simon, S. I. & Ferrara, K. W. Ultrasound Radiation Force Enables Targeted Deposition of Model Drug Carriers loaded on Microbubbles. J Control Release 111 (2006) 128-134. (Pubitemid 43290001
18. Kheirolomoom, A., Dayton, P. A., Lum, A. F. H., Little, E., Paoli, E. E., Zheng, H. & Ferrara, K. W. Acousticallyactive microbubbles conjugated to liposomes: Characterization of a proposed drug delivery vehicle. J Control Release 118 (2007) 275-284. (Pubitemid 46441545
19. Christiansen, J. P., French, B. A., Klibanov, A. L., Kaul, S. & Lindner, J. R. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol 29 (2003) 1759-1767. (Pubitemid 38091725
20. Oliveira, A. C., Ferraz, M. P., Monteiro, F. J. & Simões, S. Cationic liposome-DNA complexes as gene delivery vectors: Development and behaviour towards bone-like cells. Acta Biomater 5 (2009) 2142-2151
21. Vannan, M., McCreery, T., Li, P., Han, Z., Unger, E., Kuersten, B., Nabel, E. & Rajagopalan, S. Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA. J Am Soc Echocardiogr 15 (2002) 214-218. (Pubitemid 44964512
22. van Wamel, A., Kooiman, K., Harteveld, M., Emmer, M., ten Cate, F. J., Versluis, M. & de Jong, N. Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation. J Control Release 112 (2006) 149-155
23. van Wamel, A., Kooiman, K., Emmer, M., ten Cate, F. J., Versluis, M. & de Jong, N. Ultrasound microbubble induced endothelial cell permeability. J Control Release 116 (2006) e100-102
24. Livak, K. J. & Schmittgen, T. D. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-[Delta][Delta]CT Method. Methods 25 (2001) 402-408. (Pubitemid 34164012
25. Karmazyn, M., Liu, Q., Gan, X. T., Brix, B. J. & Fliegel, L. Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension 42 (2003) 1171-1176. (Pubitemid 37549073
26. Oshima, Y., Fujio, Y., Funamoto, M., Negoro, S., Izumi, M., Nakaoka, Y., Hirota, H., Yamauchi-Takihara, K., et al. Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway. FEBS Letters 524 (2002) 123-126. (Pubitemid 34804846
27. Abramoff, M., Magelhaes, P. & Ram, S. Image processing with ImageJ. Biophotonics Int 11 (2004) 36-42
28. Suzuki, R., Takizawa, T., Negishi, Y., Hagisawa, K., Tanaka, K., Sawamura, K., Utoguchi, N., Nishioka, T., et al. Gene delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasound. J Control Release 117 (2007) 130-136. (Pubitemid 46161862
29. Yoon, C. S. & Park, J. H. Ultrasound-mediated gene delivery. Expert Opin Drug Deliv 7 (2010) 321-330
30. Zhang, S., Xu, Y., Wang, B., Qiao, W., Liu, D. & Li, Z. Cationic compounds used in lipoplexes and polyplexes for gene delivery. J Control Release 100 (2004) 165-180. (Pubitemid 39491269
31. Wasungu, L. & Hoekstra, D. Cationic lipids, lipoplexes and intracellular delivery of genes. J Control Release 116 (2006) 255-264. (Pubitemid 44854274
32. Hirsch-Lerner, D., Zhang, M., Eliyahu, H., Ferrari, M. E., Wheeler, C. J. & Barenholz, Y. Effect of "helper lipid" on lipoplex electrostatics. Biochim. Biophys. Acta 1714 (2005) 71-84
33. Lv, H., Zhang, S.,Wang, B., Cui, S. & Yan, J. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 114 (2006) 100-109. (Pubitemid 44128621.