Focused-Ultrasound Disruption of the Blood-Brain Barrier Using Closely-Timed Short Pulses: Influence of Sonication Parameters and Injection Rate

Ultrasound in Medicine and Biology

Volumn 37, Issue 4, 2011, Pages 587-594

  O'Reilly, Meaghan A ^a   Waspe, Adam C ^a,b   Ganguly, Milan ^a   Hynynen, Kullervo ^a,b  

^a Sunnybrook Health Sciences Centre   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Blood brain barrier; Brain; Focused ultrasound; Transcranial therapy

Indexed keywords

BLOOD-BRAIN BARRIER; BURST PULSE; CONTRAST AGENT; DEFINITY; DUTY CYCLES; FOCUSED ULTRASOUND; INJECTION RATES; MICRO-BUBBLE; MICROBUBBLES; NUMBER OF CYCLES; OPTIMAL PARAMETER; PULSE SEQUENCE; SAFETY BENEFITS; SHORT BURSTS; SHORT PULSE; SINGLE-PULSE; SONICATION PARAMETERS; STANDING WAVE; STATISTICAL SIGNIFICANCE; TRANSCRANIAL;

BLOOD; DRUG DELIVERY; ULTRASONICS;

PULSE REPETITION RATE;

PERFLUTREN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ECHOGRAPHY; ERYTHROCYTE LEVEL; EXTRAVASATION; FLOW INJECTION ANALYSIS; IN VIVO STUDY; MEMBRANE TRANSPORT; MICROBUBBLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REACTION TIME;

ANIMALS; BLOOD-BRAIN BARRIER; DOSE-RESPONSE RELATIONSHIP, RADIATION; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; RADIATION DOSAGE; RATS; RATS, WISTAR; SONICATION;

EID: 79952737915     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2011.01.008     Document Type: Article

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