Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 6, 2014, Pages

  Laidlaw, Tanya M ^a,b   Cutler, Anya J ^b   Kidder, Molly S ^b   Liu, Tao ^b   Cardet, Juan Carlos ^a,b   Chhay, Heng ^b   Feng, Chunli ^b   Boyce, Joshua A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

AERD; aspirin triad; aspirin exacerbated respiratory disease; asthma; cyclic AMP; leukotriene; nonsteroidal anti inflammatory drug; protein kinase A; Samter's triad

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; LEUKOTRIENE; LEUKOTRIENE B4; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PADGEM PROTEIN; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN E2; ACETYLSALICYLIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROSTAGLANDIN E RECEPTOR 2; ADENYLATE CYCLASE; THROMBOXANE A2;

ARTICLE; ASPIRIN EXACERBATED RESPIRATORY DISEASE; ASTHMA; CONTROLLED STUDY; ENZYME ACTIVITY; EX VIVO STUDY; GRANULOCYTE; HUMAN; HUMAN CELL; NEUTROPHIL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RESPIRATORY TRACT INFLAMMATION; THROMBOCYTE ADHESION; ADULT; AERD; AGED; ASPIRIN-EXACERBATED RESPIRATORY DISEASE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG POTENTIATION; FEMALE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; NONSTEROIDAL ANTI-INFLAMMATORY DRUG; PROSTAGLANDIN E(2); RESPIRATORY TRACT DISEASE; SAMTER'S TRIAD; THROMBOCYTE; YOUNG ADULT; CELL SURFACE; CHEMICAL ANALYSIS; CLINICAL ARTICLE; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; EOSINOPHIL; PROTEIN SUBUNIT; REGULATORY MECHANISM; SUPERNATANT;

AERD; ASPIRIN-EXACERBATED RESPIRATORY DISEASE; ASTHMA; CYCLIC AMP; LEUKOTRIENE; NONSTEROIDAL ANTI-INFLAMMATORY DRUG; PROSTAGLANDIN E(2); PROTEIN KINASE A; SAMTER'S TRIAD;

ADULT; AGED; ASPIRIN; BLOOD PLATELETS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; FEMALE; GRANULOCYTES; HUMANS; LEUKOTRIENE B4; LEUKOTRIENES; MALE; MIDDLE AGED; NEUTROPHILS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RESPIRATORY TRACT DISEASES; YOUNG ADULT;

EID: 84901802659     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.12.1034     Document Type: Article

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