Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment

Brain, Behavior, and Immunity

Volumn 22, Issue 4, 2008, Pages 487-492

  Bossù, Paola ^a   Ciaramella, Antonio ^a   Salani, Francesca ^a   Bizzoni, Federica ^a   Varsi, Erika ^a   Di Iulio, Fulvia ^a   Giubilei, Franco ^b   Gianni, Walter ^c   Trequattrini, Alberto ^d   Moro, Maria Luisa ^a   Bernardini, Sergio ^e   Caltagirone, Carlo ^a,e   Spalletta, Gianfranco ^a,f  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c INRCA   (Italy)

^d Department of Mental Health   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

Alzheimer's disease; Cognitive decline; Interleukin 18

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHYPERTENSIVE AGENT; HYPOCHOLESTEROLEMIC AGENT; INTERLEUKIN 18; ORAL ANTIDIABETIC AGENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD CELL; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DEMENTIA; DIABETES MELLITUS; DISEASE EXACERBATION; FEMALE; GENOTYPE; HORMONE SUBSTITUTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPOTHYROIDISM; LOW DRUG DOSE; MALE; OVARY INFLAMMATION; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; COGNITION DISORDERS; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEVERITY OF ILLNESS INDEX;

EID: 41349088377     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.10.001     Document Type: Article

References (21)

1. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., Cooper N.R., Eikelenboom P., Emmerling M., Fiebich B.L., Finch C.E., Frautschy S., Griffin W.S., Hampel H., Hull M., Landreth G., Lue L., Mrak R., Mackenzie I.R., McGeer P.L., O'Banion M.K., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F.L., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G., and Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol. Aging 21 (2000) 383-421
2. Baune B.T., Ponath G., Golledge J., Varga G., Arolt V., Rothermundt M., and Berger K. Association between IL-8 cytokine and cognitive performance in an elderly general population-the MEMO-study. Neurobiol. Aging (2007) (Epub ahead of print)
3. Bossù P., Ciaramella A., Moro M.L., Bellincampi L., Bernardini S., Federici G., Trequattrini A., Macciardi F., Spoletini I., Di Iulio F., Caltagirone C., and Spalletta G. Interleukin-18 gene polymorphisms predict risk and outcome of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 78 (2007) 807-811
4. Bufler P., Azam T., Gamboni-Robertson F., Reznikov L.L., Kumar S., Dinarello C.A., and Kim S.H. A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc. Natl. Acad. Sci. USA 99 (2002) 13723-13728
5. Ciaramella, A., Sanarico, N., Bizzoni, F., Moro, M.L., Salani, F., Scapigliati, G., Spalletta, G., Caltagirone, C., Bossù, P., 2007. Amyloid β peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells. Neurobiol. Aging. 4, 5-8 (Jul 19; Epub ahead of print), doi:10.1016/j.neurobiolaging.2007.06.007.
6. Conti B., Park L.C., Calingasan N.Y., Kim Y., Kim H., Bae Y., Gibson G.E., and Joh T.H. Cultures of astrocytes and microglia express interleukin 18. Brain Res. Mol. Brain Res. 67 (1999) 46-52
7. Culhane A.C., Hall M.D., Rothwell N.J., and Luheshi G.N. Cloning of rat brain interleukin-18 cDNA. Mol. Psychiatry 3 (1998) 362-366
8. Di Rosa M., Dell'Ombra N., Zambito A.M., Malaguarnera M., Nicoletti F., and Malaguarnera L. Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia. Eur. J. Neurosci. 23 (2006) 2648-2656
9. Felderhoff-Mueser U., Schmidt O.I., Oberholzer A., Bührer C., and Stahel P.F. IL-18: a key player in neuroinflammation and neurodegeneration?. Trends Neurosci. 28 (2005) 487-493
10. Kanno T., Nagata T., Yamamoto S., Okamura H., and Nishizaki T. Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices. Brain Res. 1012 (2004) 190-193
11. LaFerla F.M., and Oddo S. Alzheimer's disease: a beta, tau and synaptic dysfunction. Trends Mol. Med. 11 (2005) 170-176
12. Lindberg C., Chromek M., Ahrengart L., Brauner A., Schultzberg M., and Garlind A. Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease. Neurochem. Int. 46 (2005) 551-557
13. Lombardi V.R., Garcia M., Rey L., and Cacabelos R. Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's disease (AD) individuals. J. Neuroimmunol. 97 (1999) 163-171
14. Malaguarnera L., Motta M., Di Rosa M., Anzaldi M., and Malaguarnera M. Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia. Neuropathology 26 (2006) 307-312
15. Mori I., Hossain M.J., Takeda K., Okamura H., Imai Y., Kohsaka S., and Kimura Y. Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection. Virology 287 (2001) 163-170
16. Novick D., Kim S.H., Fantuzzi G., Reznicov L.L., Dinarello C.A., and Rubinstein M. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity 10 (1999) 127-136
17. Novick D., Schwartsburd B., Pinkus R., Suissa D., Belzer I., Sthoeger Z., Keane W.F., Chvatchko Y., Kim S.H., Fantuzzi G., Dinarello C.A., and Rubinstein M. A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine 14 (2001) 334-342
18. Reale M., Iarlori C., Gambi F., Feliciani C., Salone A., Toma L., DeLuca G., Salvatore M., Conti P., and Gambi D. Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J. Neuroimmunol. 148 (2004) 162-171
19. Sugama S., Wirz S.A., Barr A.M., Conti B., Bartfai T., and Shibasaki T. Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment. Neuroscience 128 (2004) 451-458
20. Tan Z.S., Beiser A.S., Vasan R.S., Roubenoff R., Dinarello C.A., Harris T.B., Benjamin E.J., Au R., Kiel D.P., Wolf P.A., and Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham study. Neurology 68 (2007) 1902-1908
21. Yaffe K., Lindquist K., Pennix B.W., Simonsick E.M., Pahor M., Kritchevsky S., Launer L., Kuller L., Rubin S., and Harris T. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 61 (2003) 76-80