Unraveling the functions of the membrane-bound glucocorticoid receptors: First clues on origin and functional activity

Annals of the New York Academy of Sciences

Volumn 1318, Issue 1, 2014, Pages 1-6

  Strehl, Cindy ^a   Buttgereit, Frank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Estrogen receptor; Membrane bound glucocorticoid receptor; Nongenomic effects; Progesterone receptor

Indexed keywords

ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; MEMBRANE BOUND GLUCOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CYTOSOL; HUMAN;

ESTROGEN RECEPTOR; MEMBRANE-BOUND GLUCOCORTICOID RECEPTOR; NONGENOMIC EFFECTS; PROGESTERONE RECEPTOR;

HUMANS; MEMBRANE PROTEINS; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE;

EID: 84901781228     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12364     Document Type: Article

References (43)

1. Moss, G.P. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN). 1989. The nomenclature of steroids (Recommendations 1989). Pure & Appl. Chem. 61: 1783-1822.
2. Draper, N. & P.M. Stewart. 2005. 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J. Endocrinol. 186: 251-271.
3. Nussey, S. & S. Whitehead. 2001. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers.
4. Buttgereit, F., J. Seibel & J.W. Bijlsma. 2008. "Glucocorticoids." In Clinical Immunology: Principles and Practice. Chapter 87. R.R. Rich, T.A. Fleisher, W.T. Shearer, H.W. Schroeder, A.J. Frew & C.M. Weyand, Eds.: 1066-1075. Philadelphia: Elsevier Health Sciences.
5. Almawi, W.Y. & O.K. Melemedjian. 2002. Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor. J. Leukoc. Biol. 71: 9-15.
6. Song, I.H. et al. 2005. New glucocorticoids on the horizon: repress, don't activate! J. Rheumatol. 32: 1199-1207.
7. Stahn, C. & F. Buttgereit. 2008. Genomic and nongenomic effects of glucocorticoids. Nat. Clin. Pract. Rheumatol. 4: 525-533.
8. Vandevyver, S. et al. 2013. New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation. Endocrinology 154: 993-1007.
9. Strehl, C. & F. Buttgereit. 2013. Optimized glucocorticoid therapy: teaching old drugs new tricks. Mol. Cell Endocrinol 380: 32-40.
10. Buttgereit, F. & A. Scheffold. 2002. Rapid glucocorticoid effects on immune cells. Steroids 67: 529-534.
11. Falkenstein, E., A.W. Norman & M. Wehling. 2000. Mannheim classification of nongenomically initiated (rapid) steroid action(s). J. Clin. Endocrinol. Metab. 85: 2072-2075.
12. Croxtall, J.D., Q. Choudhury & R.J. Flower. 2000. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br. J. Pharmacol. 130: 289-298.
13. Cato, A.C., A. Nestl & S. Mink. 2002. Rapid actions of steroid receptors in cellular signaling pathways. Sci. STKE. 2002: re9.
14. Hafezi-Moghadam, A. et al. 2002. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat. Med. 8: 473-479.
15. Lee, S.R. et al. 2012. Non-genomic effect of glucocorticoids on cardiovascular system. Pflugers Arch. 464: 549-559.
16. Pratt, W.B. et al. 2006. Chaperoning of glucocorticoid receptors. Handb. Exp. Pharmacol. 172: 111-138.
17. Groeneweg, F.L. et al. 2012. Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling. Mol. Cell Endocrinol 350: 299-309.
18. Vernocchi, S. et al. 2013. Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects. Mol. Cell. Proteomics 12: 1764-1779.
19. Gametchu, B. 1987. Glucocorticoid receptor-like antigen in lymphoma cell membranes: correlation to cell lysis. Science 236: 456-461.
20. Orchinik, M., T.F. Murray & F.L. Moore. 1991. A corticosteroid receptor in neuronal membranes. Science 252: 1848-1851.
21. Gametchu, B., C.S. Watson & S. Wu. 1993. Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients. FASEB J. 7: 1283-1292.
22. Gametchu, B. & C.S. Watson. 2002. Correlation of membrane glucocorticoid receptor levels with glucocorticoid-induced apoptotic competence using mutant leukemic and lymphoma cells lines. J. Cell Biochem. 87: 133-146.
23. Gametchu, B. et al. 1999. Plasma membrane-resident glucocorticoid receptors in rodent lymphoma and human leukemia models. Steroids 64: 107-119.
24. Johnson, L.R. et al. 2005. Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136: 289-299.
25. Scheffold, A., S. Miltenyi & A. Radbruch. 1995. Magnetofluorescent liposomes for increased sensitivity of immunofluorescence. Immunotechnology 1: 127-137.
26. Bartholome, B. et al. 2004. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J. 18: 70-80.
27. Spies, C.M. et al. 2006. Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway. Ann. Rheum. Dis. 65: 1139-1146.
28. Tryc, A.B. et al. 2006. Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis. J. Rheumatol. 33: 2249-2253.
29. Spies, C.M. et al. 2007. Membrane glucocorticoid receptors (mGCR) on monocytes are up-regulated after vaccination. Rheumatology (Oxford) 46: 364-365.
30. Strehl, C. et al. 2013. High-sensitivity immunofluorescence staining: a comparison of the liposome procedure and the FASER technique on mGR detection. J. Fluoresc. 23: 509-518.
31. Ellmann, S. et al. 2009. Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol. Life Sci. 66: 2405-2426.
32. Pietras, R.J. & C.M. Szego. 1977. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells. Nature 265: 69-72.
33. Acconcia, F. & M. Marino. 2011. The effects of 17β-estradiol in cancer are mediated by estrogen receptor signaling at the plasma membrane. Front Physiol. 2: 30.
34. Pedram, A. et al. 2007. A conserved mechanism for steroid receptor translocation to the plasma membrane. J. Biol. Chem. 282: 22278-22288.
35. Song, R.X. et al. 2004. The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc. Natl. Acad. Sci. U. S. A. 101: 2076-2081.
36. Razandi, M. et al. 2003. Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Mol. Cell Biol. 23: 1633-1646.
37. Dressing, G.E. & P. Thomas. 2007. Identification of membrane progestin receptors in human breast cancer cell lines and biopsies and their potential involvement in breast cancer. Steroids 72: 111-116.
38. Neubauer, H. et al. 2011. The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells. Menopause 18: 845-850.
39. Zhu, Y., J. Bond & P. Thomas. 2003. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc. Natl. Acad. Sci. U. S. A. 100: 2237-2242.
40. Karteris, E. et al. 2006. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol. Endocrinol. 20: 1519-1534.
41. Strehl, C. et al. 2011. Origin and functional activity of the membrane-bound glucocorticoid receptor. Arthritis Rheum. 63: 3779-3788.
42. Norfleet, A.M. et al. 1999. Estrogen receptor-alpha detected on the plasma membrane of aldehyde-fixed GH3/B6/F10 rat pituitary tumor cells by enzyme-linked immunocytochemistry. Endocrinology 140: 3805-3814.
43. Chen, H.C. & R.V. Farese. 1999. Steroid hormones: interactions with membrane-bound receptors. Curr. Biol. 9: R478-R481.