Origin and functional activity of the membrane-bound glucocorticoid receptor

Arthritis and Rheumatism

Volumn 63, Issue 12, 2011, Pages 3779-3788

  Strehl, Cindy ^a   Gaber, Timo ^a,b   Löwenberg, Mark ^c   Hommes, Daniel W ^d   Verhaar, Auke P ^d   Schellmann, Saskia ^a   Hahne, Martin ^a,b   Fangradt, Monique ^a   Wagegg, Markus ^a,b   Hoff, Paula ^a   Scheffold, Alexander ^e   Spies, Cornelia M ^a   Burmester, Gerd Rüdiger ^a   Buttgereit, Frank ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Berlin Brandenburg Center for Regenerative Therapies   (Germany)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e MILTENYI BIOTEC GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; SMALL INTERFERING RNA;

ARTICLE; CELL LYSATE; DRUG EFFECT; ENZYME PHOSPHORYLATION; EXON; GENOMICS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MEMBRANE BINDING; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS;

CELL MEMBRANE; DEXAMETHASONE; HEK293 CELLS; HUMANS; KIDNEY; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; RNA, SMALL INTERFERING; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION;

EID: 82455212460     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30637     Document Type: Article

References (46)

1. Buttgereit F, Burmester GR, Lipworth BJ,. Optimised glucocorticoid therapy: the sharpening of an old spear. Lancet 2005; 365: 801-3. (Pubitemid 40311369)
2. Schacke H, Docke WD, Asadullah K,. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96: 23-43. (Pubitemid 35346616)
3. Schacke H, Schottelius A, Docke WD, Strehlke P, Jaroch S, Schmees N, et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci U S A 2004; 101: 227-32. (Pubitemid 38084232)
4. Da Silva JA, Jacobs JW, Kirwan JR, Boers M, Saag KG, Ines LB, et al. Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis 2006; 65: 285-93. (Pubitemid 43268214)
5. Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, Dreher R, et al. Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis 2009; 68: 1119-24.
6. Stahn C, Buttgereit F,. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol 2008; 4: 525-33.
7. Lu NZ, Cidlowski JA,. The origin and functions of multiple human glucocorticoid receptor isoforms. Ann N Y Acad Sci 2004; 1024: 102-23. (Pubitemid 38879596)
8. Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985; 318: 635-41. (Pubitemid 16172412)
9. Lu NZ, Cidlowski JA,. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 2005; 18: 331-42. (Pubitemid 41350538)
10. Lu NZ, Cidlowski JA,. Glucocorticoid receptor isoforms generate transcription specificity. Trends Cell Biol 2006; 16: 301-7. (Pubitemid 43884980)
11. Croxtall JD, Choudhury Q, Flower RJ,. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 2000; 130: 289-98. (Pubitemid 30261038)
12. Buttgereit F, Scheffold A,. Rapid glucocorticoid effects on immune cells. Steroids 2002; 67: 529-34. (Pubitemid 34311770)
13. Cato AC, Nestl A, Mink S,. Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002; 2002: re9.
14. Stahn C, Lowenberg M, Hommes DW, Buttgereit F,. Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol Cell Endocrinol 2007; 275: 71-8. (Pubitemid 47259281)
15. Spies CM, Schaumann DH, Berki T, Mayer K, Jakstadt M, Huscher D, et al. Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway. Ann Rheum Dis 2006; 65: 1139-46. (Pubitemid 44277386)
16. Song IH, Buttgereit F,. Non-genomic glucocorticoid effects to provide the basis for new drug developments. Mol Cell Endocrinol 2006; 246: 142-6. (Pubitemid 43238408)
17. Orchinik M, Murray TF, Moore FL,. A corticosteroid receptor in neuronal membranes. Science 1991; 252: 1848-51. (Pubitemid 21917109)
18. Gametchu B, Chen F, Sackey F, Powell C, Watson CS,. Plasma membrane-resident glucocorticoid receptors in rodent lymphoma and human leukemia models. Steroids 1999; 64: 107-19. (Pubitemid 29168594)
19. Bartholome B, Spies CM, Gaber T, Schuchmann S, Berki T, Kunkel D, et al. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J 2004; 18: 70-80. (Pubitemid 38076467)
20. Scheffold A, Miltenyi S, Radbruch A,. Magnetofluorescent liposomes for increased sensitivity of immunofluorescence. Immunotechnology 1995; 1: 127-37.
21. Tryc AB, Spies CM, Schneider U, Kunkel D, Berki T, Sieper J, et al. Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis. J Rheumatol 2006; 33: 2249-53. (Pubitemid 44749785)
22. Lowenberg M, Tuynman J, Bilderbeek J, Gaber T, Buttgereit F, van Deventer S, et al. Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn. Blood 2005; 106: 1703-10. (Pubitemid 41208584)
23. Lowenberg M, Verhaar AP, Bilderbeek J, Marle J, Buttgereit F, Peppelenbosch MP, et al. Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep 2006; 7: 1023-9. (Pubitemid 44480518)
24. Boldizsar F, Talaber G, Szabo M, Bartis D, Palinkas L, Nemeth P, et al. Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells. Immunobiology 2010; 215: 521-6.
25. Berki T, Kumanovics G, Kumanovics A, Falus A, Ujhelyi E, Nemeth P,. Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody. J Immunol Methods 1998; 214: 19-27. (Pubitemid 28335535)
26. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003; 33: 401-6. (Pubitemid 36278858)
27. Gametchu B, Watson CS, Wu S,. Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients. FASEB J 1993; 7: 1283-92. (Pubitemid 23314365)
28. ++ lymphoma cells: biochemical characterization and interaction with Hsp 70 and Hsp 90. Endocrine 1999; 10: 271-80. (Pubitemid 29372972)
29. Pedram A, Razandi M, Levin ER,. Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol 2006; 20: 1996-2009. (Pubitemid 44286700)
30. Li L, Haynes MP, Bender JR,. Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells. Proc Natl Acad Sci U S A 2003; 100: 4807-12. (Pubitemid 36457810)
31. Bayaa M, Booth RA, Sheng Y, Liu XJ,. The classical progesterone receptor mediates xenopus oocyte maturation through a nongenomic mechanism. Proc Natl Acad Sci U S A 2000; 97: 12607-12.
32. Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, et al. Palmitoylation-dependent estrogen receptor α membrane localization: regulation by 17β-estradiol. Mol Biol Cell 2005; 16: 231-7. (Pubitemid 40028339)
33. Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER,. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem 2007; 282: 22278-88. (Pubitemid 47267344)
34. Pelham HR,. Multiple targets for brefeldin A. Cell 1991; 67: 449-51. (Pubitemid 121001459)
35. Skildum A, Faivre E, Lange CA,. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. Mol Endocrinol 2005; 19: 327-39. (Pubitemid 40223458)
36. Faivre E, Skildum A, Pierson-Mullany L, Lange CA,. Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators. Steroids 2005; 70: 418-26. (Pubitemid 40616040)
37. Ellmann S, Sticht H, Thiel F, Beckmann MW, Strick R, Strissel PL,. Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci 2009; 66: 2405-26.
38. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994; 78: 1027-37. (Pubitemid 24292330)
39. Han J, Lee JD, Bibbs L, Ulevitch RJ,. A map kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265: 808-11. (Pubitemid 24266145)
40. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-46.
41. Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, et al. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 1994; 78: 1039-49. (Pubitemid 24292331)
42. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995; 270: 7420-6.
43. Zervos AS, Faccio L, Gatto JP, Kyriakis JM, Brent R,. Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc Natl Acad Sci U S A 1995; 92: 10531-4.
44. Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, et al. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 1999; 19: 21-30. (Pubitemid 29018406)
45. Yang SH, Galanis A, Sharrocks AD,. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol 1999; 19: 4028-38. (Pubitemid 29241977)
46. Wen Z, Zhong Z, Darnell JE Jr,. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82: 241-50.