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Volumn 21, Issue 1, 2014, Pages 28-31

Sonic hedgehog signalling pathway: A complex network

Author keywords

Autoproteolysis; Holoprosencephaly; Lipidation; Neural tube pattern; Notochord; Sonic hedgehog

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HEPARIN; PROTEOGLYCAN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PAX6;

EID: 84901761077     PISSN: 09727531     EISSN: 09763260     Source Type: Journal    
DOI: 10.5214/ans.0972.7531.210109     Document Type: Article
Times cited : (155)

References (44)
  • 1
    • 67349165028 scopus 로고    scopus 로고
    • Trafficking, development and hedgehog
    • Simpson F, Kerr MC, Wicking C. Trafficking, development and hedgehog. Mech Dev 2009; 126: 279-288.
    • (2009) Mech Dev , vol.126 , pp. 279-288
    • Simpson, F.1    Kerr, M.C.2    Wicking, C.3
  • 2
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432: 324-331.
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 3
    • 0033711384 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer
    • Toftgard R. Hedgehog signalling in cancer. CMLS, Cell Mol Life Sci 2000; 57: 1720-1731.
    • (2000) CMLS, Cell Mol Life Sci , vol.57 , pp. 1720-1731
    • Toftgard, R.1
  • 4
    • 0036155819 scopus 로고    scopus 로고
    • Hedgehog patterns midbrain ARChitecture
    • Machold R, Fishell G. Hedgehog patterns midbrain ARChitecture. Trends Neuorosci 2002; 25: 10-11.
    • (2002) Trends Neuorosci , vol.25 , pp. 10-11
    • McHold, R.1    Fishell, G.2
  • 5
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980; 287: 795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 6
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y, Epstein DJ, St-Jacques B, et al. Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity. Cell 1993; 75: 1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3
  • 7
    • 23444440157 scopus 로고
    • Floor plate and motor neuron induction by vHH-1, a vertebrate homolog of hedgehog expressed by the notochord
    • Roelink H, Augsburger A, Heemskerk J, et al. Floor plate and motor neuron induction by vHH-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 1994; 76: 761-775.
    • (1994) Cell , vol.76 , pp. 761-775
    • Roelink, H.1    Augsburger, A.2    Heemskerk, J.3
  • 8
    • 0027400583 scopus 로고
    • Induction of floor plate differentiation by contact-dependent homeogenetic signals
    • Placzek M, Jessell TM, Dodd J. Induction of floor plate differentiation by contact-dependent homeogenetic signals. Development 1993; 117: 205-218.
    • (1993) Development , vol.117 , pp. 205-218
    • Placzek, M.1    Jessell, T.M.2    Dodd, J.3
  • 9
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
    • Chiang C, Litingung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 1996; 383: 407-413.
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingung, Y.2    Lee, E.3
  • 10
    • 0032732443 scopus 로고    scopus 로고
    • The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: Shh mutations cause a significant proportion of autosomal dominant holoprosencephaly
    • Nanni L, Ming JE, Bocian M, et al. The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: Shh mutations cause a significant proportion of autosomal dominant holoprosencephaly. Hum Mol Genet 1999; 8: 2479-88.
    • (1999) Hum Mol Genet , vol.8 , pp. 2479-2488
    • Nanni, L.1    Ming, J.E.2    Bocian, M.3
  • 11
    • 0031433360 scopus 로고    scopus 로고
    • Graded sonic hedgehog signalling and the specification of cell fate in the ventral neural tube
    • Ericson J, Briscoe J, Rashbass P, et al. Graded sonic hedgehog signalling and the specification of cell fate in the ventral neural tube. Cold Spring Harb Symp Quant Biol 1997; 62: 451-457.
    • (1997) Cold Spring Harb Symp Quant Biol , vol.62 , pp. 451-457
    • Ericson, J.1    Briscoe, J.2    Rashbass, P.3
  • 12
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • Jessel TM. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 2000; 1: 20-29.
    • (2000) Nat Rev Genet , vol.1 , pp. 20-29
    • Jessel, T.M.1
  • 13
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic Hedgehog signalling required for the specification of motor neuron identity
    • Ericson J, Morton S, Kawakami A, et al. Two critical periods of Sonic Hedgehog signalling required for the specification of motor neuron identity. Cell 1996; 87: 661-673.
    • (1996) Cell , vol.87 , pp. 661-673
    • Ericson, J.1    Morton, S.2    Kawakami, A.3
  • 14
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • Marti E, Bumcrot DA, Takada R, et al. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 1995; 375: 322-325.
    • (1995) Nature , vol.375 , pp. 322-325
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3
  • 15
    • 0035252990 scopus 로고    scopus 로고
    • Specification of neuronal fates in the ventral neural tube
    • Briscoe J, Ericson J. Specification of neuronal fates in the ventral neural tube. Curr Opin Neurobiol 2001; 11: 43-49.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 43-49
    • Briscoe, J.1    Ericson, J.2
  • 16
    • 0030663064 scopus 로고    scopus 로고
    • A hedgehog activity gradient contributes to AP axial patterning of the drosophila wing
    • Strigini M, Cohen SM. A hedgehog activity gradient contributes to AP axial patterning of the drosophila wing. Development 1997; 124: 4697-4705.
    • (1997) Development , vol.124 , pp. 4697-4705
    • Strigini, M.1    Cohen, S.M.2
  • 17
    • 0028966517 scopus 로고
    • Proteolytic processing yields two secreted forms of sonic hedgehog
    • Bumcrot DA, Takada R, McMahon AP. Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 1995; 15: 2294-2303.
    • (1995) Mol Cell Biol , vol.15 , pp. 2294-2303
    • Bumcrot, D.A.1    Takada, R.2    McMahon, A.P.3
  • 18
    • 0028948811 scopus 로고
    • The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
    • Porter JA, von Kessler DP, Ekker SC, et al. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 1995; 374: 363-366.
    • (1995) Nature , vol.374 , pp. 363-366
    • Porter, J.A.1    von Kessler, D.P.2    Ekker, S.C.3
  • 20
    • 15844386540 scopus 로고    scopus 로고
    • Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxyterminal autoprocessing domain
    • Porter JA, Ekker SC, Park WJ, et al. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxyterminal autoprocessing domain. Cell 1996; 86: 21-34.
    • (1996) Cell , vol.86 , pp. 21-34
    • Porter, J.A.1    Ekker, S.C.2    Park, W.J.3
  • 21
    • 15444359695 scopus 로고    scopus 로고
    • Identification of a palmitic acid-modified form of Human Sonic hedgehog
    • Pepinsky RB, Zeng C, Wen D, et al. Identification of a palmitic acid-modified form of Human Sonic hedgehog. J Biol Chem 1998; 273: 14037-14045.
    • (1998) J Biol Chem , vol.273 , pp. 14037-14045
    • Pepinsky, R.B.1    Zeng, C.2    Wen, D.3
  • 22
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • Chamoun Z, Mann RK, Nellen D, et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 2001; 293: 2080-2084.
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3
  • 23
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of Sonic hedgehog is required for long-range signalling activity and effective modulation of signalling by Ptc1
    • Lewis PM, Dunn MP, McMahon JA, et al. Cholesterol modification of Sonic hedgehog is required for long-range signalling activity and effective modulation of signalling by Ptc1. Cell 2001; 105: 599-612.
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3
  • 24
    • 0035822098 scopus 로고    scopus 로고
    • A freely diffusible form of sonic hedgehog mediates long-range signalling
    • Zeng X, Goetz JA, Suber LM, et al. A freely diffusible form of sonic hedgehog mediates long-range signalling. Nature 2001; 411: 716-720.
    • (2001) Nature , vol.411 , pp. 716-720
    • Zeng, X.1    Goetz, J.A.2    Suber, L.M.3
  • 25
    • 0034931149 scopus 로고    scopus 로고
    • N-terminal fatty-acylation of sonic hedgehog enhances the induction of ventral forebrain neurons
    • Kohtz JD, Lee HY, Gaiano N, et al. N-terminal fatty-acylation of sonic hedgehog enhances the induction of ventral forebrain neurons. Development 2001; 128: 2351-2363.
    • (2001) Development , vol.128 , pp. 2351-2363
    • Kohtz, J.D.1    Lee, H.Y.2    Gaiano, N.3
  • 26
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signalling cells
    • Burke R, Mellen D, Bellotto M, et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signalling cells. Cell 1999; 99: 803-815.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Mellen, D.2    Bellotto, M.3
  • 27
    • 14844365003 scopus 로고    scopus 로고
    • Drosophila glypicans Dally and Dally-like shape the extracellular wingless morphogen gradient in the wing disc
    • Chun H, Dong Y, Belenkaya TY, Xinhua L. Drosophila glypicans Dally and Dally-like shape the extracellular wingless morphogen gradient in the wing disc; Development 2005; 132: 667-679.
    • (2005) Development , vol.132 , pp. 667-679
    • Chun, H.1    Dong, Y.2    Belenkaya, T.Y.3    Xinhua, L.4
  • 28
    • 2942742564 scopus 로고    scopus 로고
    • Novel lipid modifications of secreted proteins signals
    • Mann RK, Beachy PA. Novel lipid modifications of secreted proteins signals. Annu. Rev. Biochem. 2004; 73: 891-923.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 891-923
    • Mann, R.K.1    Beachy, P.A.2
  • 29
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper JE, Scott MP. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989; 59: 751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 30
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V, Davey RA, Zuo Y, et al. Biochemical evidence that patched is the Hedgehog receptor. Nature 1996; 384: 119-20.
    • (1996) Nature , vol.384 , pp. 119-120
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3
  • 31
    • 84882881997 scopus 로고    scopus 로고
    • Axonal pathfinding: Guidance activities of Sonic Hedgehog (Shh)
    • In: Squire LR, ed. [online]. Available at
    • Charron F, Tessier-Lavigne M. Axonal pathfinding: Guidance activities of Sonic Hedgehog (Shh). In: Squire LR, ed. Encyclopedia of Neuroscience 2008: 1147-1153 [online]. Available at: http://www.elsevierdirect. com/brochures/ens/content.html
    • (2008) Encyclopedia of Neuroscience , pp. 1147-1153
    • Charron, F.1    Tessier-Lavigne, M.2
  • 32
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • Taipale J, Cooper MK, Maiti T, et al. Patched acts catalytically to suppress the activity of Smoothened. Nature 2002; 418: 892-7.
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3
  • 33
    • 0032413830 scopus 로고    scopus 로고
    • In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
    • Chen Y, Struhl G. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 1998; 125: 4943-8.
    • (1998) Development , vol.125 , pp. 4943-4948
    • Chen, Y.1    Struhl, G.2
  • 34
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo J, Ayzenzon M, Von Ohlen T, et al. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996; 86: 221-32.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3
  • 36
    • 0033529667 scopus 로고    scopus 로고
    • Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
    • Chen CH, von Kessler DP, Park W, et al. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 1999; 98: 305-316.
    • (1999) Cell , vol.98 , pp. 305-316
    • Chen, C.H.1    von Kessler, D.P.2    Park, W.3
  • 37
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc P, Ramirez-Weber FA, Laget MP, et al. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 1997; 89: 1043-53.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3
  • 38
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signalling network
    • Cohen MM Jr. The hedgehog signalling network. Am J Med Genet A. 2003; 123: 5-28.
    • (2003) Am J Med Genet A. , vol.123 , pp. 5-28
    • Cohen Jr., M.M.1
  • 39
    • 0035577854 scopus 로고    scopus 로고
    • McMahon, Hedgehog signalling in animal development: Paradigms and principles
    • Philip WI, Andrew P. McMahon, Hedgehog signalling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Philip, W.I.1    Andrew, P.2
  • 40
    • 0036468983 scopus 로고    scopus 로고
    • Principles of cargo attachment to cytoplasmic motor proteins
    • Kamal A, Goldstein LS. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol 2002; 14: 63-68.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 63-68
    • Kamal, A.1    Goldstein, L.S.2
  • 41
    • 0035914377 scopus 로고    scopus 로고
    • The fused protein kinase regulates hedgehog-stimulated transcriptional activation in drosophila schneider 2 cells
    • Fukumoto T, Watanabe-Fukunaga R, Fujisawa K, et al. The fused protein kinase regulates hedgehog-stimulated transcriptional activation in drosophila schneider 2 cells. J Biol Chem 2001; 276: 38441-38448.
    • (2001) J Biol Chem , vol.276 , pp. 38441-38448
    • Fukumoto, T.1    Watanabe-Fukunaga, R.2    Fujisawa, K.3
  • 42
    • 0036778132 scopus 로고    scopus 로고
    • Hedgehog signal transduction: Recent findings
    • Nybakken K, Perrimon N. Hedgehog signal transduction: recent findings. Curr Opin Genet Dev 2002; 12: 503-11.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 503-511
    • Nybakken, K.1    Perrimon, N.2
  • 43
    • 0011102935 scopus 로고    scopus 로고
    • The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone DM, Hynes M, Armanini M, et al. The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996; 384: 129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3
  • 44
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins DJ, Nybakken KE, Kobayashi R, et al. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2 Cell 1997; 90: 225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3


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