Increasing cancer-specific gene expression by targeting overexpressed α5β1 integrin and upregulated transcriptional activity of NF-κB

Molecular Pharmaceutics

Volumn 11, Issue 3, 2014, Pages 849-858

  Adil, Maroof M ^a   Levine, Rachel M ^a   Kokkoli, Efrosini ^a  

^a University of Minnesota   (United States)

Author keywords

alpha(5)beta(1) integrin; gene therapy; nanoparticles; NF B; targeted delivery; transcriptional targeting

Indexed keywords

CELL PROTEIN; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN FRAGMENT A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOSOME; LUCIFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; PEPTIDE FRAGMENT;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER TISSUE; CELL DEATH; CELL GROWTH; CELL VIABILITY; COLORECTAL CANCER; CYTOTOXICITY; DOSE RESPONSE; EMBRYO; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UPREGULATION; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; CELL CULTURE; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; METABOLISM; PATHOLOGY; PLASMID; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL PROLIFERATION; CELLS, CULTURED; COLORECTAL NEOPLASMS; DIPHTHERIA TOXIN; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; HUMANS; INTEGRIN ALPHA5BETA1; LIPOSOMES; LUCIFERASES; NF-KAPPA B; PEPTIDE FRAGMENTS; PLASMIDS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84901741245     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400535v     Document Type: Article

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