Extracellular matrix proteins and chemoradiotherapy: α5β1 integrin as a predictive marker in rectal cancer

European Journal of Surgical Oncology

Volumn 28, Issue 1, 2002, Pages 30-36

  Jayne, David G ^a,b   Heath, R M ^a   Dewhurst, O ^a   Scott, N ^a   Guillou, P J ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b NONE   (Singapore)

Author keywords

Combined modality therapy; Extracellular matrix proteins; Rectal neoplasm

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN TYPE 4; FIBRONECTIN; FIBRONECTIN RECEPTOR; LAMININ; SCLEROPROTEIN; VERY LATE ACTIVATION ANTIGEN 5;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MITOSIS INDEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CANCER; TUMOR BIOPSY; METABOLISM; MULTIMODALITY CANCER THERAPY; PATHOLOGY; RECTUM TUMOR;

APOPTOSIS; COLLAGEN TYPE IV; COMBINED MODALITY THERAPY; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; HUMANS; IMMUNOHISTOCHEMISTRY; LAMININ; MITOTIC INDEX; RECEPTORS, FIBRONECTIN; RECTAL NEOPLASMS;

EID: 0036482847     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1053/ejso.2001.1182     Document Type: Article

References (33)

1. Chari RS, Tyler DS, Anscher MS, Russell L, Clary BM, Hathorn J, Seigler HF. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann Surg 1995; 221: 778-786.
2. Grann A, Minsky BD, Cohen AM, Saltz L, Guillem JG, Paty PB, Kelsen DP, Kemeny N, Ilson D, Bass-Loeb J. Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin, and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis Colon Rectum 1997; 40: 515-22.
3. Habr-Gama A, de Souza PM, Ribeiro UJ, Nadalin W, Gansl R, Sousa AHJ, Campos FG, Gama-Rodrigues J. Low rectal cancer: impact of radiation and chemotherapy on surgical treatment. Dis Colon Rectum 1998; 41: 1087-96.
4. Valentini V, Coco C, Cellini N, Picciocchi A, Genovesi D, Mantini G, Barbaro B, Cogliandolo S, Mattana C, Ambesi-Impiombato F, Tedesco M, Cosimelli M. Preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys 1998; 40: 1067-75.
5. Berger C, Kirscher S, Felix-Faure C, Chauvet B, Vincent P, Brewer Y, Reboul F. Preoperative concurrent radiochemotherapy for cancer of the rectum. Cancer Radiother 1998; 2: 260-5.
6. Chan A, Wong A, Langevin J, Khoo R. Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys 1993; 25: 791-9.
7. Hyams DM, Mamounas EP, Petrelli N, Rockette H, Jones J, Wieand HS, Deutsch M, Wickerham L, Fisher B, Wolmark N. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of National Surgical Breast and Bowel Project Protocol R-03. Dis Colon Rectum 1997; 40: 131-9.
8. Ross GM. Induction of cell death by radiotherapy. Endocr Relat Cancer 1999; 6: 41-4.
9. Zhivotovsky B, Joseph B, Orrenius S. Minireview: tumour radiosensitivity and apoptosis. Exp Cell Res 1999; 248: 10-17.
10. Ruoslahti E. Integrin signaling and matrix assembly. Tumour Biol 1996; 17: 117-24.
11. Varner JA, Emerson DA, Juliano RL. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell 1995; 6: 725-40.
12. Schmidt R, Streit M, Kaiser R, Herzberg F, Schirner M, Schramm K, Kaufmann C, Henneken M, Schafer-Korting M, Thiel E, Kreuser ED. De novo expression of the alpha-5beta1-fibronectin receptor in HT29 colon-cancer cells reduces activity of C-SRC. Increase of C-SRC activity by attachment on fibronectin. Int J Cancer 1998; 76: 91-8.
13. Gong J, Ko TC, Brattain MG. Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase. J Biol Chem 1998; 273: 1662-9.
14. Zhang Z, Vuori K, Reed JC, Ruoslahti E. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 1995; 92: 6161-5.
15. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 1995; 267: 891-3.
16. Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, Chilvers ER, Dransfield I, Donnelly SC, Strieter R, Haslett C. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 1999; 5: 662-8.
17. Nishioka A, Ogawa Y, Inomata T, Maeda T, Seguchi H. Fibronectin expression in cancer tissues from patients undergoing radiation therapy. Histol Histopath 1993; 8: 457-62.
18. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Disease 1997; 12: 19-23.
19. Stryker SJ, Kiel KD, Rademaker A, Shaw JM, Ujiki GT, Poticha SM. Preoperative chemoradiation for stages II and III rectal carcinoma. Arch Surg 1996; 131: 514-9.
20. Hanamura N, Yoshida T, Matsumoto E, Kawarada Y, Sakakura T. Expression of fibronectin and tenascin-C mRNA by myofibroblasts, vascular cells and epithelial cells in human colon adenomas and carcinomas. Int J Cancer 1997; 73: 10-15.
21. Hauptmann S, Zardi L, Siri A, Carnemolla B, Borsi L, Castellucci M, Klosterhalfen B, Hartung P, Weis J, Stocker G. Extracellular matrix proteins in colorectal carcinomas. Expression of tenascin and fibornectin isoforms. Lab Invest 1995; 73: 172-82.
22. Midulla M, Verma R, Pignatelli M, Ritter MA, Courtenay L, Georger AJ. Source of oncofetal ED-B-containing fibronectin: implications of production by both tumour and endothelial cells. Cancer Res 2000; 60: 164-9.
23. Hida J, Matsuda T, Kitaoka M, Machidera N, Kubo R, Yasutomi M. The role of basement membrane in colorectal cancer invasion and liver metastasis. Cancer 1994; 74: 592-8.
24. Rajagopal S, Huang S, Albitar M, Chakrabarty S. Control of fibronectin receptor expression by fibronectin: antisense fibronectin RNA downregulates the induction of fibronectin receptor by transforming growth factor beta 1. J Cell Physiol 1997; 170: 138-44.
25. Danen EH, Sonneveld P, Sonnenberg A, Yamada KM. Dual stimulation of Ras/mitogen-activated protein kinase and Rho A by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J Cell Biol 2000; 151: 1413-22.
26. 1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol-3-kinase and protein kinase bB-dependent pathway. Mol Biol Cell 2000; 11: 1973-87.
27. Scott N, Hale A, Deakin M, Hand P, Adab FA, Hall C, Williams GT, Elder JB. A histopathological assessment of the response of rectal adenocarcinoma to combination chemo-radiotherapy: relationship to apoptotic activity, p53 and bcl-2 expression. Eur J Surg Oncol 1998; 24: 169-73.
28. Hall PA. Assessing apoptosis: a critical survey. Endocr Relat Cancer 1999; 6: 3-8.
29. Tannapfel A, Nusslein S, Katalinic A, Kockerling F, Wittekind C, Fietkau R. [Proliferation and apoptosis before and after preoperative simultaneous radiochemotherapy of rectal carcinomas]. Strahlenther Onkol 1998; 174: 295-9.
30. Stuschke M, Budach V, Sack H. Radioresponsiveness of human glioma, sarcoma, and breast cancer spheroids depends on tumour differentiation. Int J Radiat Oncol Biol Phys 1993; 27: 627-36.
31. Berger C, de Muret A, Garaud P, Chapet S, Bourlier P, Reynaud-Bougnoux A, Dorval E, de Calan L, Huten N, le Folch O, Calais G. Preoperative radiotherapy (RT) for rectal cancer: predictive factors of tumor downstaging and residual tumor cell density (RTCD): prognostic implications. Int J Radiat Oncol Biol Phys 1997; 37: 619-27.
32. Rognoni JB, Pichard V, Honore S, Rigot V, Lehmann M, Roccabianca M, Carles G, Luis J, Marvaldi J, Briand C. Convergent effects of growth factors, hormones, and fibronectin are necessary for the enterocyte differentiation of a colon adenocarcinoma cell line (HT29-D4). Differentiation 1998; 63: 305-17.
33. Huang S, Chakrabarty S. Regulation of fibronectin and laminin receptor expression, fibronectin and laminin secretion in human colon cancer cells by transforming growth factor-beta I. Int J Cancer 1994; 57: 742-6.