메뉴 건너뛰기




Volumn 95, Issue 6, 2014, Pages 961-970

MTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressor cells in protecting against murine immunological hepatic injury

Author keywords

Autoimmune; Cell migration; Immune defense; Inflammation; Inflammatory cell infiltration

Indexed keywords

CD11B ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN; NITRIC OXIDE; RAPAMYCIN;

EID: 84901715203     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0913473     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Chi, H. (2012) Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325-338.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 325-338
    • Chi, H.1
  • 2
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
    • Liu, G., Burns, S., Huang, G., Boyd, K., Proia, R. L., Flavell, R. A., Chi, H. (2009) The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat. Immunol. 10, 769-777.
    • (2009) Nat. Immunol. , vol.10 , pp. 769-777
    • Liu, G.1    Burns, S.2    Huang, G.3    Boyd, K.4    Proia, R.L.5    Flavell, R.A.6    Chi, H.7
  • 3
    • 83655211587 scopus 로고    scopus 로고
    • MTOR regulates T-cell differentiation and activation in immunity and autoimmunity
    • Bi, Y., Liu, G., Yang, R. (2011) mTOR regulates T-cell differentiation and activation in immunity and autoimmunity. Crit. Rev. Eukaryot. Gene Expr. 21, 313-322.
    • (2011) Crit. Rev. Eukaryot. Gene Expr. , vol.21 , pp. 313-322
    • Bi, Y.1    Liu, G.2    Yang, R.3
  • 5
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., Efeyan, A., Sabatini, D. M. (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell. Biol. 12, 21-35.
    • (2011) Nat. Rev. Mol. Cell. Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 6
    • 67349217332 scopus 로고    scopus 로고
    • Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
    • Baker, A. K., Wang, R., Mackman, N., Luyendyk, J. P. (2009) Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression. Mol. Immunol. 46, 2249-2255.
    • (2009) Mol. Immunol. , vol.46 , pp. 2249-2255
    • Baker, A.K.1    Wang, R.2    McKman, N.3    Luyendyk, J.P.4
  • 8
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., Hall, M. N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 9
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin
    • Dumont, F. J., Staruch, M. J., Koprak, S. L., Melino, M. R., Sigal, N. H. (1990) Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J. Immunol. 144, 251-258.
    • (1990) J. Immunol. , vol.144 , pp. 251-258
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3    Melino, M.R.4    Sigal, N.H.5
  • 10
    • 84891526383 scopus 로고    scopus 로고
    • Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity
    • Yang, H., Wang, X., Zhang, Y., Liu, H., Liao, J., Shao, K., Chu, Y., Liu, G. (2014) Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity. J. Cell. Physiol. 229, 17-26.
    • (2014) J. Cell. Physiol. , vol.229 , pp. 17-26
    • Yang, H.1    Wang, X.2    Zhang, Y.3    Liu, H.4    Liao, J.5    Shao, K.6    Chu, Y.7    Liu, G.8
  • 11
    • 84885101700 scopus 로고    scopus 로고
    • Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+CD25+Foxp3+ regulatory T-cell development in mice
    • Chen, H., Zhang, L., Zhang, H., Xiao, Y., Shao, L., Li, H., Yin, H., Wang, R., Liu, G., Corley, D., Yang, Z., Zhao, Y. (2013) Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+CD25+Foxp3+ regulatory T-cell development in mice. FASEB J. 27, 3979-3990.
    • (2013) FASEB J. , vol.27 , pp. 3979-3990
    • Chen, H.1    Zhang, L.2    Zhang, H.3    Xiao, Y.4    Shao, L.5    Li, H.6    Yin, H.7    Wang, R.8    Liu, G.9    Corley, D.10    Yang, Z.11    Zhao, Y.12
  • 12
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • Sehgal, S. N. (2003) Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 35, 7S-14S.
    • (2003) Transplant. Proc. , vol.35
    • Sehgal, S.N.1
  • 13
    • 67650553603 scopus 로고    scopus 로고
    • MTOR: Taking cues from the immune microenvironment
    • Delgoffe, G. M., Powell, J. D. (2009) mTOR: taking cues from the immune microenvironment. Immunology 127, 459-465.
    • (2009) Immunology , vol.127 , pp. 459-465
    • Delgoffe, G.M.1    Powell, J.D.2
  • 15
    • 79961167174 scopus 로고    scopus 로고
    • Lung myeloid-derived suppressor cells and regulation of inflammation
    • Ray, P., Arora, M., Poe, S. L., Ray, A. (2012) Lung myeloid-derived suppressor cells and regulation of inflammation. Immunol. Res. 50, 153-158.
    • (2012) Immunol. Res. , vol.50 , pp. 153-158
    • Ray, P.1    Arora, M.2    Poe, S.L.3    Ray, A.4
  • 16
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt, S. K., Yang, L., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 67, 10019-10026.
    • (2007) Cancer Res. , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 17
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg, S., Sinha, P. (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499-4506.
    • (2009) J. Immunol. , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 19
    • 79952198443 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Characterization and expansion in models of endotoxemia and transplantation
    • Van Rompaey, N., Le Moine, A. (2010) Myeloid-derived suppressor cells: characterization and expansion in models of endotoxemia and transplantation. Methods Mol. Biol. 677, 169-180.
    • (2010) Methods Mol. Biol. , vol.677 , pp. 169-180
    • Van Rompaey, N.1    Le Moine, A.2
  • 20
    • 84893873953 scopus 로고    scopus 로고
    • SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF1α-dependent glycolysis
    • Liu, G., Bi, Y., Shen, B., Yang, H., Zhang, Y., Wang, X., Liu, H., Lu, Y., Liao, J., Chen, X., Chu, Y. (2014) SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF1α-dependent glycolysis. Cancer Res. 74, 727-737.
    • (2014) Cancer Res. , vol.74 , pp. 727-737
    • Liu, G.1    Bi, Y.2    Shen, B.3    Yang, H.4    Zhang, Y.5    Wang, X.6    Liu, H.7    Lu, Y.8    Liao, J.9    Chen, X.10    Chu, Y.11
  • 21
    • 79952772423 scopus 로고    scopus 로고
    • Paired immunoglobin-like receptor B regulates the suppressive function and fate of myeloid-derived suppressor cells
    • Ma, J., Pan, P. Y., Eisenstein, S., Divino, C. M., Lowell, C. A., Takai, T., Shu-Hsia, C. (2011) Paired immunoglobin-like receptor B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity 25, 385-395.
    • (2011) Immunity , vol.25 , pp. 385-395
    • Ma, J.1    Pan, P.Y.2    Eisenstein, S.3    Divino, C.M.4    Lowell, C.A.5    Takai, T.6    Shu-Hsia, C.7
  • 22
    • 2142711534 scopus 로고    scopus 로고
    • Alleviating effects of si-ni-san, a traditional Chinese prescription, on experimental liver injury and its mechanisms
    • Jiang, J., Zhou, C., Xu, Q. (2003) Alleviating effects of si-ni-san, a traditional Chinese prescription, on experimental liver injury and its mechanisms. Biol. Pharm. Bull. 26, 1089-1094.
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1089-1094
    • Jiang, J.1    Zhou, C.2    Xu, Q.3
  • 24
    • 77957932965 scopus 로고    scopus 로고
    • Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver
    • Cripps, J. G., Wang, J., Maria, A., Blumenthal, I., Gorham, J. D. (2010) Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver. Hepatology 52, 1350-1359.
    • (2010) Hepatology , vol.52 , pp. 1350-1359
    • Cripps, J.G.1    Wang, J.2    Maria, A.3    Blumenthal, I.4    Gorham, J.D.5
  • 25
    • 84872593818 scopus 로고    scopus 로고
    • Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1
    • Liu, G., Hu, X., Sun, B., Yang, T., Shi, J., Zhang, L., Zhao, Y. (2013) Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood 121, 519-529.
    • (2013) Blood , vol.121 , pp. 519-529
    • Liu, G.1    Hu, X.2    Sun, B.3    Yang, T.4    Shi, J.5    Zhang, L.6    Zhao, Y.7
  • 26
    • 84868544881 scopus 로고    scopus 로고
    • Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway
    • Wu, T., Sun, C., Chen, Z., Zhen, Y., Peng, J., Qi, Z., Yang, X., Zhao, Y. (2012) Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway. J. Immunol. 189, 4989-5000.
    • (2012) J. Immunol. , vol.189 , pp. 4989-5000
    • Wu, T.1    Sun, C.2    Chen, Z.3    Zhen, Y.4    Peng, J.5    Qi, Z.6    Yang, X.7    Zhao, Y.8
  • 30
    • 79959564980 scopus 로고    scopus 로고
    • Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection
    • Blomgran, R., Ernst, J. D. (2013) Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection. J. Immunol. 186, 7110-7119.
    • (2013) J. Immunol. , vol.186 , pp. 7110-7119
    • Blomgran, R.1    Ernst, J.D.2
  • 32
    • 84878941596 scopus 로고    scopus 로고
    • Early bilateral cystoid macular oedema secondary to fingolimod in multiple sclerosis
    • Liu, L., Cuthbertson, F. (2012) Early bilateral cystoid macular oedema secondary to fingolimod in multiple sclerosis. Case Report Med. 12, 134636-134643.
    • (2012) Case Report Med. , vol.12 , pp. 134636-134643
    • Liu, L.1    Cuthbertson, F.2
  • 33
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt, S. K., Yang, L., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 15, 10019-10026.
    • (2007) Cancer Res. , vol.15 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 34
    • 84869791457 scopus 로고    scopus 로고
    • Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma
    • Kodumudi, K. N., Weber, A., Sarnaik, A. A., Pilon-Thomas, S. (2011) Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. J. Immunol. 189, 5147-5154.
    • (2011) J. Immunol. , vol.189 , pp. 5147-5154
    • Kodumudi, K.N.1    Weber, A.2    Sarnaik, A.A.3    Pilon-Thomas, S.4
  • 35
    • 84860902300 scopus 로고    scopus 로고
    • Histone deacetylase inhibition facilitates GMCSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo
    • Rosborough, B. R., Castellaneta, A., Natarajan, S., Thomson, A. W., Turnquist, H. R. (2013) Histone deacetylase inhibition facilitates GMCSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. J. Leukoc. Biol. 91, 701-709.
    • (2013) J. Leukoc. Biol. , vol.91 , pp. 701-709
    • Rosborough, B.R.1    Castellaneta, A.2    Natarajan, S.3    Thomson, A.W.4    Turnquist, H.R.5
  • 36
    • 77954399377 scopus 로고    scopus 로고
    • Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    • Sander, L. E., Sackett, S. D., Dierssen, U., Beraza, N., Linke, R. P., Muller, M., Blander, J. M., Tacke, F., Trautwein, C. (2009) Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453-1464.
    • (2009) J. Exp. Med. , vol.207 , pp. 1453-1464
    • Sander, L.E.1    Sackett, S.D.2    Dierssen, U.3    Beraza, N.4    Linke, R.P.5    Muller, M.6    Blander, J.M.7    Tacke, F.8    Trautwein, C.9
  • 38
    • 0035154559 scopus 로고    scopus 로고
    • Immunosuppressive drugs in paediatric liver transplantation
    • Van Mourik, I. D., Kelly, D. A. (2001) Immunosuppressive drugs in paediatric liver transplantation. Paediatr. Drugs 3, 43-60.
    • (2001) Paediatr. Drugs , vol.3 , pp. 43-60
    • Van Mourik, I.D.1    Kelly, D.A.2
  • 40
    • 80052646150 scopus 로고    scopus 로고
    • Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus
    • Chen, S., Akbar, S. M., Abe, M., Hiasa, Y., Onji, M. (2011) Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin. Exp. Immunol. 166, 134-142.
    • (2011) Clin. Exp. Immunol. , vol.166 , pp. 134-142
    • Chen, S.1    Akbar, S.M.2    Abe, M.3    Hiasa, Y.4    Onji, M.5
  • 42
    • 84867778778 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxiainducible factor 1 α
    • Mcinturff, A. M., Cody, M. J., Elliott, E. A., Glenn, J. W., Rowley, J. W., Rondina, M. T., Yost, C. C. (2012) Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxiainducible factor 1 α. Blood 120, 3118-3125.
    • (2012) Blood , vol.120 , pp. 3118-3125
    • McInturff, A.M.1    Cody, M.J.2    Elliott, E.A.3    Glenn, J.W.4    Rowley, J.W.5    Rondina, M.T.6    Yost, C.C.7
  • 45
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • Hackstein, H., Taner, T., Zahorchak, A. F., Morelli, A. E., Logar, A. J., Gessner, A., Thomson, A. W. (2003) Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 101, 4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3    Morelli, A.E.4    Logar, A.J.5    Gessner, A.6    Thomson, A.W.7
  • 46
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist, H. R., Raimondi, G., Zahorchak, A. F., Fischer, R. T., Wang, Z., Thomson, A. W. (2007) Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178, 7018-7031.
    • (2007) J. Immunol. , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 47
    • 79953658580 scopus 로고    scopus 로고
    • Role of myeloidderived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
    • Hegde, V.l., Nagarkatti, P. S., Nagarkatti, M. (2011) Role of myeloidderived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. PLoS One 6, e18281.
    • (2011) PLoS One , vol.6
    • Hegde, V.1    Nagarkatti, P.S.2    Nagarkatti, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.