Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 306, Issue 11, 2014, Pages

  Ueta, Kiichiro ^a   O'Brien, Tracy P ^a   McCoy, Gregory A ^a   Kim, Kuikwon ^a   Healey, Erin C ^a   Farmer, Tiffany D ^a   Donahue, E Patrick ^a   Condren, Audree B ^a   Printz, Richard L ^a   Shiota, Masakazu ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glucokinase; Glucotoxicity; Hepatic glucose flux; Sodium glucose cotransporter 2 inhibitor; Type 2 diabetes

Indexed keywords

CANAGLIFLOZIN; CORTICOSTERONE; FATTY ACID; GLUCAGON; GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; GLYCOGEN; HEMOGLOBIN A1C; INSULIN; LACTIC ACID; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); REGULATOR PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL NUCLEUS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOPLASM; DIABETIC OBESITY; DIET RESTRICTION; DISEASE COURSE; ENZYME ACTIVITY; FAT MASS; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GENE EXPRESSION; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; GLUCOSE URINE LEVEL; GLUCOTOXICITY; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LEAN BODY WEIGHT; LIPID LIVER LEVEL; MALE; MEAL; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHOSPHORYLATION; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY QUOTIENT; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; ZUCKER DIABETIC FATTY RAT;

GLUCOKINASE; GLUCOTOXICITY; HEPATIC GLUCOSE FLUX; SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR; TYPE 2 DIABETES;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; EATING; GLUCAGON; GLUCOKINASE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLUCOSIDES; HYPERGLYCEMIA; HYPERINSULINISM; IMMUNOHISTOCHEMISTRY; LIVER; MALE; OBESITY; ORGAN SIZE; OXYGEN CONSUMPTION; RATS; RATS, ZUCKER; RNA, MESSENGER; SODIUM-GLUCOSE TRANSPORTER 2; THIOPHENES;

EID: 84901705119     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00507.2013     Document Type: Article

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