Profiling of rpoB mutations and MICs for rifampin and rifabutin in mycobacterium tuberculosis

Journal of Clinical Microbiology

Volumn 52, Issue 6, 2014, Pages 2157-2162

  Jamieson, F B ^a,b   Guthrie, J L ^a   Neemuchwala, A ^a   Lastovetska, O ^a   Melano, R G ^a,b   Mehaffy, C ^a,b  

^a PUBLIC HEALTH ONTARIO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RIFABUTIN; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; BACTERIAL PROTEIN; DNA DIRECTED RNA POLYMERASE; RPOB PROTEIN, MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSTATIC AGENT;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM ISOLATE; CODON; DNA EXTRACTION; DNA POLYMORPHISM; GENE MUTATION; GENE SEQUENCE; HUMAN; INCIDENCE; LABORATORY DIAGNOSIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; MORTALITY; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PRIORITY JOURNAL; TUBERCULOSIS; BACTERIAL GENOME; DNA SEQUENCE; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MUTATION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA-DIRECTED RNA POLYMERASES; GENOME, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; RIFABUTIN; RIFAMPIN; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS;

EID: 84901686255     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00691-14     Document Type: Article

References (35)

1. World Health Organization. 2014. Global tuberculosis report 2013. World Health Organization, Geneva, Switzerland. www.who.int/tb/publications/global- report/en/.
2. Marsili L, Pasqualucci CR, Vigevani A, Gioia B, Schioppacassi G, Oronzo G. 1981. New rifamycins modified at positions 3 and 4. Synthesis, structure and biological evaluation. J. Antibiot. 34:1033-1038. (Pubitemid 12243994)
3. Ramaswamy S, Musser JM. 1998. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber. Lung Dis. 79:3-29. http://dx.doi.org/10.1054/tuld.1998.0002.
4. Telenti A, Imboden P, Marchesi F, Lowrie D, Cole S, Colston MJ, Matter L, Schopfer K, Bodmer T. 1993. Detection of rifampicinresistance mutations in Mycobacterium tuberculosis. Lancet 341:647-650. http://dx.doi.org/10.1016/0140- 6736(93)90417-F. (Pubitemid 23083244)
5. Lee SS, Meintjes G, Kamarulzaman A, Leung CC. 2013. Management of tuberculosis and latent tuberculosis infection in human immunodeficiency virus-infected persons. Respirology 18:912-922. http://dx.doi.org/10.1111/resp. 12120.
6. Yang B, Koga H, Ohno H, Ogawa K, Fukuda M, Hirakata Y, Maesaki S, Tomono K, Tashiro T, Kohno S. 1998. Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 42: 621-628. http://dx.doi.org/10.1093/ jac/42.5.621. (Pubitemid 28510620)
7. Sch?n T, Jur?en P, Chryssanthou E, Giske CG, Kahlmeter G, Hoffner S, Angeby K. 2013. Rifampicin-resistant and rifabutin-susceptible Mycobacterium tuberculosis strains: a breakpoint artefact? J. Antimicrob. Chemother. 68:2074-2077. http://dx.doi.org/10.1093/jac/dkt150.
8. Musser JM. 1995. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 8:496-514.
9. Louw GE, Warren RM, Gey van Pittius NC, McEvoy CRE, Van Helden PD, Victor TC. 2009. A balancing act: efflux/influx in mycobacterial drug resistance. Antimicrob. Agents Chemother. 53:3181-3189. http://dx.doi.org/10.1128/AAC.01577- 08.
10. Ohno H, Koga H, Kohno S, Tashiro T, Hara K. 1996. Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. Antimicrob. Agents Chemother. 40:1053-1056. (Pubitemid 26115251)
11. Rigouts L, Gumusboga M, de Rijk WB, Nduwamahoro E, Uwizeye C, de Jong B, Van Deun A. 2013. Rifampin resistance missed in automated liquid culture system for Mycobacterium tuberculosis isolates with specific rpoB mutations. J. Clin. Microbiol. 51:2641-2645. http://dx.doi.org/10.1128/JCM.02741-12.
12. Clemente WT, Soares Lima SS, Palaci M, Silva MSN, Sumnienski Rodrigues VF, Dalla Costa ER, Possuelo L, Cafrune PI, Ribeiro FK, Gomes HM, Serufo JC. 2008. Phenotypic and genotypic characterization of drug-resistant Mycobacterium tuberculosis strains. Diagn. Microbiol. Infect. Dis. 62:199-204. http://dx.doi.org/10.1016/j.diagmicrobio.2008.06.013.
13. Pang Y, Lu J, Wang Y, Song Y, Wang S, Zhao Y. 2013. Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 57:893-900. http://dx.doi.org/10.1128/AAC.01024-12.
14. Van Deun A, Barrera L, Bastian I, Fattorini L, Hoffmann H, Kam KM, Rigouts L, R?sch-Gerdes S, Wright A. 2009. Mycobacterium tuberculosis strains with highly discordant rifampin susceptibility test results. J. Clin. Microbiol. 47:3501-3506. http://dx.doi.org/10.1128/JCM.01209-09.
15. Van Deun A, Wright A, Zignol M, Weyer K, Rieder HL. 2011. Drug susceptibility testing proficiency in the network of supranational tuberculosis reference laboratories. Int. J. Tuberc. Lung Dis. 15:116-124.
16. Van Deun A, Aung KJM, Bola V, Lebeke R, Hossain MA, de Rijk WB, Rigouts L, Gumusboga A, Torrea G, de Jong BC. 2013. Rifampin drug resistance tests for tuberculosis: challenging the gold standard. J. Clin. Microbiol. 51:2633-2640. http://dx.doi.org/10.1128/JCM.00553-13.
17. Taniguchi H, Aramaki H, Nikaido Y, Mizuguchi Y, Nakamura M, Koga T, Yoshida S. 1996. Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 144:103-108. http://dx.doi.org/10.1111/j.1574-6968.1996.tb08515.x. (Pubitemid 26343117)
18. Somoskovi A, Dormandy J, Mitsani D, Rivenburg J, Salfinger M. 2006. Use of smear-positive samples to assess the PCR-based genotype MTBDR assay for rapid, direct detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampin. J. Clin. Microbiol. 44: 4459-4463. http://dx.doi.org/10.1128/JCM.01506-06. (Pubitemid 44940754)
19. Sirgel FA, Warren RM, B?ttger EC, Klopper M, Victor TC, van Helden PD. 2013. The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks. PLoS One 8:e59414. http://dx.doi.org/10.1371/journal. pone.0059414.
20. Bolotin S, Alexander DC, Chedore P, Drews SJ, Jamieson F. 2009. Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada. J. Antimicrob. Chemother. 64:263-266. http://dx.doi.org/10. 1093/jac/dkp183.
21. Pfyffer GE, Bonato DA, Ebrahimzadeh A, Gross W, Hotaling J, Kornblum J, Laszlo A, Roberts G, Salfinger M, Wittwer F, Siddiqi S. 1999. Multicenter laboratory validation of susceptibility testing of Mycobacterium tuberculosis against classical second-line and newer antimicrobial drugs by using the radiometric BACTEC 460 technique and the proportion method with solid media. J. Clin. Microbiol. 37:3179-3186. (Pubitemid 29455202)
22. van Soolingen D, Hermans PW, de Haas PE, Soll DR, van Embden JD. 1991. Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequencedependent DNA polymorphism as a tool in the epidemiology of tuberculosis. J. Clin. Microbiol. 29:2578-2586.
23. Roetzer A, Diel R, Kohl TA, R?ckert C, N?bel U, Blom J, Wirth T, Jaenicke S, Schuback S, R?sch-Gerdes S, Supply P, Kalinowski J, Niemann S. 2013. Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: a longitudinal molecular epidemiological study. PLoS Med. 10:e1001387. http://dx.doi.org/10.1371/journal.pmed.1001387.
24. Williams DL, Waguespack C, Eisenach K, Crawford JT, Portaels F, Salfinger M, Nolan CM, Abe C, Sticht-Groh V, Gillis TP. 1994. Characterization of rifampin-resistance in pathogenic mycobacteria. Antimicrob. Agents Chemother. 38:2380-2386. http://dx.doi.org/10.1128/AAC.38.10.2380.
25. Tang K, Sun H, Zhao Y, Guo J, Zhang C, Feng Q, He Y, Luo M, Li Y, Sun Q. 2013. Characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Sichuan in China. Tuberculosis (Edinb.) 93:89-95. http://dx.doi.org/10.1016/j.tube.2012.10.009.
26. B?rtfai Z, Somosk?vi A, K?dm?n C, Szab? N, Pusk?s E, Kosztol?nyi L, Farag? E, Mester J, Parsons LM, Salfinger M. 2001. Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay. J. Clin. Microbiol. 39:3736-3739. http://dx.doi.org/10.1128/JCM.39.10.3736-3739.2001. (Pubitemid 32954534)
27. Ramaswamy SV, Reich R, Dou S-J, Jasperse L, Pan X, Wanger A, Quitugua T, Graviss EA. 2003. Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 47:1241-1250. http://dx.doi.org/10.1128/AAC.47.4.1241-1250.2003. (Pubitemid 36372035)
28. Chen H-Y, Yu M-C, Huang W-L, Wu M-H, Chang Y-L, Che C-R, Jou R. 2012. Molecular detection of rifabutin-susceptible Mycobacterium tuberculosis. J. Clin. Microbiol. 50:2085-2088. http://dx.doi.org/10.1128/JCM.00652-12.
29. Cavusoglu C, Karaca-Derici Y, Bilgic A. 2004. In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Clin. Microbiol. Infect. 10:662-665. http://dx.doi.org/10. 1111/j.1469-0691.2004.00917.x. (Pubitemid 39077057)
30. Gill SK, Garcia GA. 2011. Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro. Tuberculosis (Edinb.) 91:361-369. http://dx.doi.org/10.1016/j.tube.2011.05.002.
31. Heep M, Rieger U, Beck D, Lehn N. 2000. Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 44:1075-1077. http://dx.doi.org/10.1128/AAC.44.4.1075-1077.2000. (Pubitemid 30165295)
32. Siu GKH, Zhang Y, Lau TCK, Lau RWT, Ho P-L, Yew W-W, Tsui SKW, Cheng VCC, Yuen K-Y, Yam W-C. 2011. Mutations outside the rifampicin resistance- determining region associated with rifampicin resistance in Mycobacterium tuberculosis. J. Antimicrob. Chemother. 66:730-733. http://dx.doi.org/10.1093/ jac/dkq519.
33. Gupta AK, Katoch VM, Chauhan DS, Sharma R, Singh M, Venkatesan K, Sharma VD. 2010. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 16:21-28. http://dx.doi.org/10.1089/mdr.2009.0054.
34. Brandis G, Wrande M, Liljas L, Hughes D. 2012. Fitness-compensatory mutations in rifampicin-resistant RNA polymerase. Mol. Microbiol. 85: 142-151. http://dx.doi.org/10.1111/j.1365-2958.2012.08099.x.
35. De Vos M, M?ller B, Borrell S, Black PA, van Helden PD, Warren RM, Gagneux S, Victor TC. 2013. Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission. Antimicrob. Agents Chemother. 57:827-832. http://dx.doi.org/10. 1128/AAC.01541-12.