Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro

Tuberculosis

Volumn 91, Issue 5, 2011, Pages 361-369

  Gill, Sumandeep K ^a   Garcia, George A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Antibacterial agents; Drug resistance; Rifamycins; RNA polymerase inhibitors

Indexed keywords

BACTERIAL VECTOR; RIFABUTIN; RIFAMPICIN; RIFAMYCIN; RIFAXIMIN; RNA POLYMERASE BETA SUBUNIT;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BACTERIUM MUTANT; CELL MEMBRANE PERMEABILITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME PURIFICATION; ESCHERICHIA COLI; EXPRESSION VECTOR; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CLUSTER ANALYSIS; DNA-DIRECTED RNA POLYMERASES; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RIFAMYCINS; TUBERCULOSIS; UP-REGULATION;

EID: 80052772699     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2011.05.002     Document Type: Article

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