Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter priori and Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 4, 2000, Pages 1075-1077

  Heep, Markus ^a,b   Rieger, Ulrich ^a   Beck, Daniela ^a   Lehn, Norbert ^a  

^a Institute for Medical Microbiology and Hygiene   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; LANSOPRAZOLE; RIFABUTIN; RIFAMPICIN; RIFAMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; CODON; CONTROLLED STUDY; GENE AMPLIFICATION; GENE CLUSTER; GENE MUTATION; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CODON; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE; HELICOBACTER PYLORI; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMYCINS;

EID: 0034118311     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.4.1075-1077.2000     Document Type: Article

References (17)

1. Akada, J. K., M. Shirai, K. Fujii, K. Okita, and T. Nakazawa. 1999. In vitro anti-Helicobacter pylori activities of new rifamycin derivatives, KRM-1648 and KRM-1657. Antimicrob. Agents Chemother. 43:1072-1076.
2. Berg, D. E., L.-G. Janaki, T. I. Engin, S. Kalpana, and N. S. Akopyants. 1997. H. pylori DNA fingerprinting using the arbitrarily primed PCR (AP-PCR) or random amplified polymorphic DNA (RAPD) method. Methods Mol. Med. 8:117-132.
3. Cooksey, R. C., G. P. Morlock, S. Glickman, and J. T. Crawford. 1997. Evaluation of a line probe assay kit for characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from New York City. J. Clin. Microbiol. 35:1281-1283.
4. Heep, M., D. Beck, E. Bayerdörffer, and N. Lehn. 1999. Rifampin and rifabutin resistance mechanism in Helicobacler pylori. Antimicrob. Agents Chemother. 43:1497-1499.
5. Kapur, V., L. L. Li, S. Iordanescu, M. R. Hamrick, A. Wanger, B. N. Kreiswirth, and J. M. Musser. 1994. Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymcrase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas. J. Clin. Microbiol. 32:1095-1098.
6. Lisitsyn, N. A., E. D. Sverdlov, E. P. Moiseyeva, O. N. Danilevskaya, and V. G. Nikiforov. 1984. Mutation to rifampicin resistance at the beginning of the RNA polymerase beta subunit gene in Escherichia coli. Mol. Gen. Genet. 196:173-174.
7. Matsiota-Bernard, P., G. Vrioni, and E. Marinis. 1998. Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece. J. Clin. Microbiol. 36:20-23.
8. Musser, J. M. 1995. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 8:496-514.
9. Ohno, H., H. Koga, S. Kohno, T. Tashiro, and K. Hara. 1996. Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. Antimicrob. Agents Chemother. 40:1053-1056.
10. Perri, F., V. Festa, and A. Andriulli. 1998. Treatment of antibiotic-resistant Helicobacter pylori infection. N. Engl. J. Med. 339:53.
11. Severinov, K., M. Soushko, A. Goldfarb, and V. Nikiforov. 1993. Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase. J. Biol. Chem. 268:14820-14825.
12. Severinov, K., M. Soushko, A. Goldfarb, and V. Nikiforov. 1994. RifR mutations in the beginning of the Escherichia coli rpoB gene. Mol. Gen. Genet. 244:120-126.
13. Telenti, A., P. Imboden, F. Marchesi, D. Lowrie, S. Cole, M. J. Colston, L. Matter, K. Schopfer, and T. Bodmer. 1993. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 341:647-650.
14. Tomb, J. F., O. White, A. R. Kerlavage, R. A. Clayton, G. G. Sutlon, R. D. Fleischmann, K. A. Ketchum, H. P. Klenk, S. Gill, B. A. Dougherty, K. Nelson, J. Quackenbush, L. Zhou, E. F. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H. G. Khalak, A. Glodek, K. McKenney, L. M. Fitzegerald, N. Lee, M. D. Adams, and J. C. Venter. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547.
15. Troyer, J. M., S. Radulovic, S. G. Andersson, and A. F. Azad. 1998. Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi. Antimicrob. Agents Chemother. 42:1845-1846.
16. Williams, D. L., L. Spring, L. Collins, L. P. Miller, L. B. Heifets, P. R. Gangadharam, and T. P. Gillis. 1998. Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 42:1853-1857.
17. Yang, B., H. Koga, H. Ohno, K. Ogawa, M. Fukuda, Y. Hirakata, S. Maesaki, K. Tomono, T. Tashiro, and S. Kohno. 1998. Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 42:621-628.