Phytochemical constituents, nutritional values, phenolics, flavonols, flavonoids, antioxidant and cytotoxicity studies on Phaleria macrocarpa (Scheff.) Boerl fruits

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Lay, Ma M ^a   Karsani, Saiful A ^a,b   Mohajer, Sadegh ^a   Abd Malek, Sri N ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Antioxidants; Cytoxicity; Flavonoids; Flavonol; Nutritional values; Phaleria macrocarpa (Scheff.) Boerl fruits or P. macrocarpa; Phenol; Phytochemicals

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIOXIDANT; CHLOROFORM; FLAVONOID; FLAVONOL DERIVATIVE; GLYCOSIDE; HEXANE; METHANOL; PHENOL DERIVATIVE; PLANT MEDICINAL PRODUCT; SAPONIN; STEROID; TANNIN DERIVATIVE; TERPENOID; WATER; PLANT EXTRACT;

ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CARBOHYDRATE ANALYSIS; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG CYTOTOXICITY; DRUG SCREENING; FAT CONTENT; FRUIT; HUMAN; HUMAN CELL; MEDICINAL PLANT; MOISTURE; NUTRITIONAL VALUE; PHALERIA MACROCARPA; PROTEIN DETERMINATION; CHEMISTRY; DRUG EFFECTS; HT 29 CELL LINE; INDONESIA; MCF 7 CELL LINE; THYMELAEACEAE;

ANTIOXIDANTS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; FLAVONOLS; FRUIT; HT29 CELLS; HUMANS; INDONESIA; MCF-7 CELLS; NUTRITIVE VALUE; PHENOLS; PLANT EXTRACTS; TANNINS; THYMELAEACEAE;

EID: 84901683060     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-152     Document Type: Article

References (39)

1. Susanthy E. N-Hexane Extract Cytotoxicity Beans and Meat Mahkota Dewa Fruit (Phaleria Macrocarpa [Scheff.] Boerl.) Against HeLa and Myeloma Cell Line 2005, 47-50. Yogyakarta: Skripsi FMIPA UGM.
2. Hartati W, Mae S, Mubarika S, Gandjar GI, Hamann TM, Rao K. Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [ Phaleria macrocarpa (Scheff.) Boerl. ] Leaves. Majalah Farmasi Indones 2005, 16(1):51-57.
3. Jemal A, Siegel R, Ward E. Cancer statistics. CA Cancer J Clin 2007, 57(1):46-66.
4. Harmanto N. Mahkota Dewa Obat Pusaka Para Dewa 2002, 4-11. Jakarta: Cetakan keempat,Agromedia Pustaka.
5. Rudi H, Syahida A, Aspollah S, Yunus Shukor M, Ehsan O. Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit. Int J Mol Sci 2011, 12:3422-3431. 10.3390/ijms12063422, 3131569, 21747685.
6. Triastuti A, Choi JW. Protective effects of ethyl acetate fraction of Phaleria macrocarpa (Scheff) Boerl. on oxidative stress asssociated with alloxan-induced diabetic rats. J Ilmiah Farmasi 2008, 5(1):9-17.
7. Sugiwati S, Setiasih S, Afifah E. Antihypergl ycemic activity of the mahkota dewa leaf. extracts as an alpha-glucosidase inhibitor. J Logika 2009, 13(2):74-78.
8. Triastuti A, Park E-J, Choi JW. Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats. Nat Prod Sci 2009, 15(3):167-172.
9. Rudi H, Ahmad S, Oskoueian E, Sukari A, Shukor MY. Antioxidant, anti-inflammatory and cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff fruit. BMC Complement Altern Med 2011, 11(1):110. 10.1186/1472-6882-11-110, 3354343, 22070850.
10. Evans WC. Trease and Evans Pharmacognosy. 2002, 528-541. Saunder: Saunder, 15.
11. Harborne J. Phytochemical Methods 1973, London: Chapman and Hall Ltd.
12. AOAC Official Methods of Analysis 2000, Gaithersburg, MD,USA: Gaithersburg, MD,USA, 17, AOAC.
13. AOAC Official Methods of Analysis 2002, Arlington: Association of Official Analytical Chemists, AOAC.
14. Alekhya C, Yasodamma N, Chaithra D, Job Roger Binny A. Anthelmintic activity of aeschynomene aspera and aeschynomene indica. Int J Pharm Pharm Sci 2013, 5(2):386-388.
15. Horwitz W. Official Method of Analysis 2000, Maryland, USA: AOAC Interantional, 17.
16. Adedapo A, Jimoh F, Koduru S, Masika J, Afolayan A. Assessment of the medicinal potentials of the methanol extracts of the leaves and stems of Buddleja saligna. BMC Complement Altern Med 2009, 9:9-21. 10.1186/1472-6882-9-9, 2680396, 19386106.
17. Koncić M, Kremer D, Gruz J, Strnad M, Bisevac G, Kosalec I. Antioxidant and antimicrobial properties of Moltkia petraea (tratt.) Griseb. flower, leaf and stem infusions. Food Chem Toxicol 2001, 48(6):1537-1542.
18. McDonald S, Prenzler PD, Autolovich M, Robards K. Phenolic content and antioxidant activity of olive oil extracts. Food Chem Biol Interact 2001, 73:73-84.
19. Nabavi S, Ebrahimzadeh M, Nabavi S, Hamidinia A, Bekhradnia A. Determination of antioxidant activity, phenol and flavonoids content of Parrotia persica Mey. Pharmacol Online 2008, 2:560-567.
20. Tarunpreet ST, Rajbir S, Rajbir K, Geetanjali R, Saroj A. In vitro antiradical properties and total phenolic contents in methanol extract/fractions from bark of Schleichera oleosa (Lour.) Oken. Med Chem Res 2011, 20(2):254-260.
21. Ebrahimzadeh M, Nabavi S, Nabavi S. Antioxidant activities of methanol extract of sambucus ebulus L. flower. Pak J Biol Sci 2001, 12:447-450.
22. Ordonez A, Gomez J, Vattuone M, Isla M. Antioxidant activities of Sechium edule (Jacq). Food Chem 2006, 97:452-458.
23. Kumaran A, Karunakaran R, . 344-352. ST In vitro antioxidant activities of methanol extracts of five Phyllantus species from India. Food Sci Technol 2007, 40:344-352. 344-352. ST.
24. Mbaebie B, Edeoga H, Afolayan A. Phytochemical analysis and antioxidants activities of aqueous stem bark extract of Schotia latifolia Jacq. Asian Pac J Trop Biomed 2012, 2(2):118-124. 10.1016/S2221-1691(11)60204-9, 3609248, 23569880.
25. Mensor LI, Menezes FS, Leitao GG, Reis AS, dos Santos T, Coube CS, Leitao SG. Screening of Brazilian plants extracts for antioxidants activity by the use of DPPH free radical method. Phytother Res 2001, 15:127-130. 10.1002/ptr.687, 11268111.
26. Yanping H, Shunquan L, Yueming J, Muhammad A. Variation in contents of total phenolics and flavonoids and antioxidant activities in the leaves of 11 eriobotrya species. Plant Foods Hum Nutr 2008, 63(4):200. 10.1007/s11130-008-0088-6, 18726693.
27. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival, modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986, 89:271-277. 10.1016/0022-1759(86)90368-6, 3486233.
28. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63. 10.1016/0022-1759(83)90303-4, 6606682.
29. Jitender M, Chetan SC, Manu S. Human epithelial carcinoma cytotoxicity and inhibition of DMBA/TPA induced squamous cell carcinoma in Balb/c mice by Acacia catechu heartwood. J Pharm Pharmacol 2011, 63(11):1470-1482. 10.1111/j.2042-7158.2011.01354.x, 21988428.
30. Sayago-Ayerdi SG, Arranz S, Serrano J, Goni I. Dietary fiber content and associated antioxidant compounds in roselle flower (Hibiscus sabdariffa L.) beverage. J Agric Food Chem 2007, 55(19):7886-7890. 10.1021/jf070485b, 17705439.
31. Oliver Chen C, Blumberg J. Are there age-related changes in flavonoid bioavailability? Phytochemicals aging and health 2008, New York: Taylor Francis Group.
32. Manjunatha B. Antibacterial activity of Pterocarpus santalinus. Indian J Pharm Sci 2006, 68(1):115-116.
33. Arts I, Hollman P. Polyhenols and disease risk in epidemiological studies. Am J Clin Nutr 2005, 81:317S-325S.
34. Rievere C, Nguyen V, Pieters L, Dejaegher B, Heyden Y, Minh C. Polyphenols isolated from antiradical extracts of Mallotus metcalfianus. Phytochemistry 2009, 70:86-94. 10.1016/j.phytochem.2008.10.008, 19062052.
35. De-Lucca A, Cleveland T, Rajasekara K, Boue S, Brown R. Fungal Properties of CAY-1, a Plant Saponin, for Emerging Fungal Pathogens. 45th Interscience Conference in Antimicrobial Agents and Chemotherapy Abstract 2005, 180. Washington, D.C: ARS, Food and Feed Safety Research.
36. Wijayani W. Sitotoksisitas Minyak Atsiri Biji dan Daging Buah Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl.) Terhadap Myeloma Cell Line dan HeLa Cell Line Serta Identifikasi Senyawa Minyak Atsiri dengan Kromatografi Gas-Spektrometri Massa (GC-MS) 2005, 41-50. Yogyakarta: Skripsi FMIPA UGM.
37. Rohyami Y. Penentuan Kandungan Flavonoid dari Ekstrak Metanol Daging Buah Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl]. J Logika 2009, 5(1):5-8.
38. Tambunan RM, Simanjuntak P. Determination of chemical structure of antioxidant compound benzophenon glycoside from n-butanol extract of the fruits of Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.]. Majalah Farmasi Indones 2006, 17(4):184-189.
39. Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H, Kuwano H. Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol 2007, 30:605-613.