Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages

  Wiener, Zoltán ^a   Band, Arja M ^a   Kallio, Pauliina ^a   Högström, Jenny ^a   Hyvönen, Ville ^a   Kaijalainen, Seppo ^a   Ritvos, Olli ^b   Haglund, Caj ^c   Kruuna, Olli ^c   Robine, Sylvie ^d   Louvard, Daniel ^d   Ben Neriah, Yinon ^e   Alitalo, Kari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d CNRS   (France)

^e HEBREW UNIVERSITY   (Israel)

Author keywords

ABT 263; ABT 737; Colon cancer; Crypt culture; Wnt pathway

Indexed keywords

APC PROTEIN; BIM PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADENOMA; ADENOMA CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENICITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; INTESTINAL STEM CELL; INTESTINE ADENOMA; INTESTINE CRYPT; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE K RAS; PRIORITY JOURNAL; PROGENY; STEM CELL; UPREGULATION; WILD TYPE;

ABT-263; ABT-737; COLON CANCER; CRYPT CULTURE; WNT PATHWAY;

ADENOMA; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATOGRAPHY, GEL; DNA PRIMERS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL NEOPLASMS; MEMBRANE PROTEINS; MICE; MICROARRAY ANALYSIS; ORGANOIDS; PROTO-ONCOGENE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84901650243     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406444111     Document Type: Article

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