Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium/endothelium interface

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Morton, Charles Oliver ^a   Fliesser, Mirjam ^b   Dittrich, Marcus ^b   Mueller, Tobias ^b   Bauer, Ruth ^b   Kneitz, Susanne ^b   Hope, William ^c   Rogers, Thomas Richard ^d   Einsele, Hermann ^b   Loeffler, Juergen ^b  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CD209 ANTIGEN; CXCL2 CHEMOKINE; DECTIN 1; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FUNGAL RNA; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; LIPID BILAYER; TRANSCRIPTOME;

A549 CELL LINE; ARTICLE; ASPERGILLUS FUMIGATUS; BILAYER MEMBRANE; CCL18 GENE; CCL20 GENE; CD209 GENE; CLEC7A GENE; CONTROLLED STUDY; CXCL2 GENE; CXCL5 GENE; DENDRITIC CELL; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IL1B GENE; IMMUNE RESPONSE; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER CELL LINE; LUNG ENDOTHELIUM; MICROARRAY ANALYSIS; MOLECULAR PROBE; MONOCYTE DERIVED DENDRITIC CELL; MYELOID DENDRITIC CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; UPREGULATION; CELL LINE; CYTOLOGY; GENE ONTOLOGY; IMMUNOLOGY; LIPID BILAYER; LUNG ALVEOLUS; LUNG ASPERGILLOSIS; METABOLISM; MICROBIOLOGY; PROTEIN MICROARRAY; RESPIRATORY TRACT MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

ASPERGILLUS FUMIGATUS; CELL LINE; DENDRITIC CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HUMANS; LIPID BILAYERS; PROTEIN ARRAY ANALYSIS; PULMONARY ALVEOLI; PULMONARY ASPERGILLOSIS; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 84901623790     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098279     Document Type: Article

References (46)

1. Gugnani HC (2003) Ecology and taxonomy of pathogenic aspergilli. Front Biosci 8: s346-357.
2. Latge JP (1999) Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 12: 310-350.
3. Hope WW, Walsh TJ, Denning DW (2005) The invasive and saprophytic syndromes due to Aspergillus spp. Med Mycol 43 Suppl 1: S207-238. (Pubitemid 41038572)
4. Neofytos D, Horn D, Anaissie E, Steinbach W, Olyaei A, et al. (2009) Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin Infect Dis 48: 265-273.
5. Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, et al. (2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460: 1117-1121.
6. Hope WW (2009) Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary aspergillosis. Med Mycol 47 Suppl 1: S291-298.
7. Park SJ, Mehrad B (2009) Innate immunity to Aspergillus species. Clinical microbiology reviews 22: 535-551.
8. Hope WW, Kruhlak MJ, Lyman CA, Petraitiene R, Petraitis V, et al. (2007) Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy. The Journal of infectious diseases 195: 455-466. (Pubitemid 46146125)
9. Schaller M, Mailhammer R, Korting HC (2002) Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis. Journal of medical microbiology 51: 672-676. (Pubitemid 34804291)
10. Schaller M, Korting HC, Borelli C, Hamm G, Hube B (2005) Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun 73: 2758-2765. (Pubitemid 40570342)
11. Schaller M, Boeld U, Oberbauer S, Hamm G, Hube B, et al. (2004) Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis. Microbiology 150: 2807-2813. (Pubitemid 39317783)
12. Hope WW, Kruhlak MJ, Lyman CA, Petraitiene R, Petraitis V, et al. (2007) Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy. J Infect Dis 195: 455-466. (Pubitemid 46146125)
13. Loeffler J, Haddad Z, Bonin M, Romeike N, Mezger M, et al. (2009) Interaction analyses of human monocytes co-cultured with different forms of Aspergillus fumigatus. J Med Microbiol 58: 49-58.
14. Cortez KJ, Lyman CA, Kottilil S, Kim HS, Roilides E, et al. (2006) Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus. Infect Immun 74: 2353-2365.
15. Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, et al. (2011) The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. PLoS One 6: e16016.
16. Mezger M, Kneitz S, Wozniok I, Kurzai O, Einsele H, et al. (2008) Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes. J Infect Dis 197: 924-931. (Pubitemid 351417017)
17. Sugui JA, Kim HS, Zarember KA, Chang YC, Gallin JI, et al. (2008) Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils. PLoS One 3: e2655.
18. McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, et al. (2008) Subtelomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4: e1000154.
19. Vermaelen K, Pauwels R (2005) Pulmonary dendritic cells. Am J Respir Crit Care Med 172: 530-551. (Pubitemid 41232964)
20. Bozza S, Gaziano R, Spreca A, Bacci A, Montagnoli C, et al. (2002) Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 168: 1362-1371. (Pubitemid 34094507)
21. Park SJ, Burdick MD, Brix WK, Stoler MH, Askew DS, et al. (2010) Neutropenia enhances lung dendritic cell recruitment in response to Aspergillus via a cytokine-to-chemokine amplification loop. J Immunol 185: 6190-6197.
22. Tournier JN, Mohamadzadeh M (2010) Key roles of dendritic cells in lung infection and improving anthrax vaccines. Trends Mol Med 16: 303-312.
23. Shetron-Rama LM, Herring-Palmer AC, Huffnagle GB, Hanna P (2010) Transport of Bacillus anthracis from the lungs to the draining lymph nodes is a rapid process facilitated by CD11c+ cells. Microb Pathog 49: 38-46.
24. Spinnler K, Mezger M, Steffens M, Sennefelder H, Kurzai O, et al. (2010) Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus. Medical mycology: official publication of the International Society for Human and Animal Mycology 48: 589-597.
25. Bellanger AP, Millon L, Khoufache K, Rivollet D, Bieche I, et al. (2009) Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549. J Med Microbiol 58: 174-179.
26. Oosthuizen JL, Gomez P, Ruan J, Hackett TL, Moore MM, et al. (2011) Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus. PLoS One 6: e20527.
27. Gafa V, Lande R, Gagliardi MC, Severa M, Giacomini E, et al. (2006) Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response. Infect Immun 74: 1480-1489. (Pubitemid 43346780)
28. Osugi Y, Vuckovic S, Hart DN (2002) Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes. Blood 100: 2858-2866.
29. Moalli F, Jaillon S, Inforzato A, Sironi M, Bottazzi B, et al. (2011) Pathogen recognition by the long pentraxin PTX3. J Biomed Biotechnol 2011: 830421.
30. Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, et al. (2014) Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 370: 421-432.
31. Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, et al. (2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 3: e13.
32. Chiang LY, Sheppard DC, Gravelat FN, Patterson TF, Filler SG (2008) Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease. Infect Immun 76: 3429-3438.
33. Gaziano R, Bozza S, Bellocchio S, Perruccio K, Montagnoli C, et al. (2004) Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother 48: 4414-4421. (Pubitemid 39434905)
34. Romani L (2008) Cell mediated immunity to fungi: a reassessment. Med Mycol 46: 515-529.
35. Ok M, Einsele H, Loeffler J (2011) Genetic susceptibility to Aspergillus fumigatus infections. Int J Med Microbiol 301: 445-452.
36. Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, et al. (1997) Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 272: 5846-5853. (Pubitemid 27102418)
37. Chang MS, McNinch J, Basu R, Simonet S (1994) Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. J Biol Chem 269: 25277-25282. (Pubitemid 24336204)
38. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, et al. (2005) ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood 106: 584-592. (Pubitemid 40981255)
39. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
40. Smyth GK, Speed TP (2003) Normalization of cDNA microarray data. Methods 31: 265-273. (Pubitemid 37338763)
41. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Statistical applications in genetics and molecular biology 3: Article3.
42. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Met 57: 289-300.
43. Oksanen J, Blanchet FG, Kindt R, Legendre P, O'Hara RB, et al. (2011) vegan: Community Ecology Package.
44. Ballarin A, Bazzan E, Zenteno RH, Turato G, Baraldo S, et al. (2012) Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 186: 233-239.
45. Lynn DJ, Winsor GL, Chan C, Richard N, Laird MR, et al. (2008) InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Mol Syst Biol 4: 218.
46. Hanley PJ, Kronlage M, Kirschning C, del Rey A, Di Virgilio F, et al. (2012) Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. The Journal of biological chemistry 287: 10650-10663.