Transport mechanism of doxorubicin loaded chitosan based nanogels across intestinal epithelium

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 1, 2014, Pages 197-207

  Feng, Chao ^a   Sun, Guohui ^a   Wang, Zhiguo ^b   Cheng, Xiaojie ^a   Park, Hyunjin ^c   Cha, Dongsu ^c   Kong, Ming ^a   Chen, Xiguang ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b QINGDAO UNIVERSITY   (China)

^c Korea University   (South Korea)

Author keywords

Carboxymethyl chitosan; Doxorubicin hydrochloride; Drug permeability; Nanogels; Oral delivery; Transport pathway

Indexed keywords

CALCIUM ION; CHITOSAN; DOXORUBICIN; NANOGEL; NANOPARTICLE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DRUG CARRIER; GEL; NANOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CELL JUNCTION; COLON ADENOCARCINOMA; CYTOTOXICITY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TRANSPORT; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; MALE; MOLECULAR MECHANICS; NONHUMAN; RAT; TRANSCYTOSIS; ANIMAL; CACO 2 CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GEL; INTESTINE ABSORPTION; INTESTINE MUCOSA; METABOLISM; ORAL DRUG ADMINISTRATION; SMALL INTESTINE; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL SURVIVAL; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; ENDOCYTOSIS; GELS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICROSCOPY, FLUORESCENCE; NANOSTRUCTURES; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84901622051     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.11.007     Document Type: Article

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