Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: In vitro and in vivo evaluation

International Journal of Pharmaceutics

Volumn 457, Issue 1, 2013, Pages 158-167

  Feng, Chao ^a   Wang, Zhiguo ^b   Jiang, Changqing ^c   Kong, Ming ^a   Zhou, Xuan ^a   Li, Yang ^a   Cheng, Xiaojie ^a   Chen, Xiguang ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b QINGDAO UNIVERSITY   (China)

^c QINGDAO MUNICIPAL HOSPITAL   (China)

Author keywords

Carboxymethyl chitosan; Chitosan; Doxorubicin hydrochloride; Oral drug delivery; pH responsive

Indexed keywords

CHITOSAN; DOXORUBICIN; NANOPARTICLE; POLYELECTROLYTE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CARDIOTOXICITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SAFETY; DUODENUM; IN VITRO STUDY; IN VIVO STUDY; JEJUNUM; MALE; MOLECULAR STABILITY; MUCOADHESION; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; STATIC ELECTRICITY; TISSUE DISTRIBUTION; WEIGHT REDUCTION; ZETA POTENTIAL;

CARBOXYMETHYL CHITOSAN; CHITOSAN; DOXORUBICIN HYDROCHLORIDE; ORAL DRUG DELIVERY; PH-RESPONSIVE;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; BODILY SECRETIONS; CATALASE; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; HEART; INTESTINAL ABSORPTION; KIDNEY; MALE; MALONDIALDEHYDE; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TISSUE DISTRIBUTION;

EID: 84885333960     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.079     Document Type: Article

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