MiR-21 regulates N-methyl-N-nitro-N'-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2

Toxicology Letters

Volumn 228, Issue 3, 2014, Pages 147-156

  Yang, Qiaoyuan ^a   Xu, Enwu ^b   Dai, Jiabin ^a   Wu, Jianjun ^a   Zhang, Shaozhu ^a   Peng, Baoying ^a   Jiang, Yiguo ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Gastric cancer; MicroRNA; MiR 21; MNNG; Tumorigenesis

Indexed keywords

FAS LIGAND; METHYLNITRONITROSOGUANIDINE; MICRORNA 21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL TRANSLOCATION GENE 2; B LYMPHOCYTE; CANCER CELL CULTURE; CARCINOGENICITY; CELL GROWTH; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; GENE; GENE CONTROL; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH CARCINOGENESIS; WESTERN BLOTTING;

GASTRIC CANCER; MICRORNA; MIR-21; MNNG; TUMORIGENESIS;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; BINDING SITES; CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMEDIATE-EARLY PROTEINS; METHYLNITRONITROSOGUANIDINE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; RNA INTERFERENCE; STOMACH NEOPLASMS; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84901601030     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.05.005     Document Type: Article

References (45)

1. Abe M., Yamashita S., Kuramoto T., Hirayama Y., Tsukamoto T., Ohta T., Tatematsu M., Ohki M., Takato T., Sugimura T., Ushijima T. Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis 2003, 24:861-867.
2. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
3. Asangani I.A., Rasheed S.A., Nikolova D.A., Leupold J.H., Colburn N.H., Post S., Allgayer H. MicroRNA-21 (miR-21) post-transcriptionally down-regulates tumor suppressor Pdcd4 and stimulatesinvasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27:2128-2136.
4. Buller B., Liu X., Wang X., Zhang R.L., Zhang L., Hozeska-Solgot A., Chopp M., Zhang Z.G. MicroRNA-21 protects neurons from ischemic death. FEBS J. 2010, 277:4299-4307.
5. Bushati N., Cohen S.M. MicroRNA functions. Annu. Rev. Cell Dev. Biol. 2007, 23:175-205.
6. Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., Shimizu M., Rattan S., Bullrich F., Negrini M., Croce C.M. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Nat. Acad. Sci. U.S.A. 2004, 101:2999-3004.
7. Chen T. The role of microRNA in chemical carcinogenesis. J. Environ. Sci. Health C: Environ. Carcinog Ecotoxicol. Rev. 2010, 28:89-124.
8. Crew K.D., Neugut A.I. Epidemiology of gastric cancer. World J. Gastroenterol. 2006, 12:354-362.
9. Davidson L.A., Wang N., Shah M.S., Lupton J.R., Ivanov I., Chapkin R.S. n-3 polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 2009, 30:2077-2084.
10. Jonge D.E., Wolters P.J., Steyerberg L.M., Dekken VAN E.W., Kusters H., Kuipers J.G., Siersema P.D E.J. Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort. Aliment. Pharmacol. Ther. 2007, 26:31-39.
11. Drakaki A., Iliopoulos D. MicroRNA gene networks in oncogenesis. Curr. Genomics 2009, 10:35-41.
12. Emma L.T., Timothy W.G. Emerging fundamental roles for non-coding RNA species in toxicology. Toxicology 2008, 246:34-39.
13. Forman D., Burley V.J. Gastric cancer: global pattern of the disease and an overview of environmental risk factors. Best Pract. Res. Clin. Gastroenterol. 2006, 20:633-649.
14. Frankel L.B., Christoffersen N.R., Jacobsen A., Lindow M., Krogh A., Lund A.H. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21in breast cancer cells. J. Biol. Chem. 2008, 283:1026-1033.
15. Franken N.A., Rodermond H.M., Stap J., Haveman J., Van Bree C. Clonogenic assay of cells in vitro. Nat. Protoc. 2006, 1:2315-2319.
16. He X.P., Shao Y., Li X.L., Xu W., Chen G.S., Sun H.H., Xu H.C., Xu X., Tang D., Zheng X.F., Xue Y.P., Huang G.C., Sun W.H. Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. FEBS J. 2012, 279:4201-4212.
17. Kalscheuer S., Zhang X., Zeng Y., Upadhyaya P. Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 2008, 29:2394-2399.
18. Kamangar F., Dores G.M., Anderson W.F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 2006, 24:2137-2150.
19. Kloosterman W.P., Plasterk R.H. The diverse functions of microRNAs in animal development and disease. Dev. Cell 2006, 11:441-450.
20. Koscianska E., Baev V., Skreka K., Oikonomaki K., Rusinov V., Tabler M., Kalantidis K. Prediction and preliminary validation of oncogene regulation by miRNAs. BMC Mol. Biol. 2007, 8:79-95.
21. Kovalchuk O., Tryndyak V.P., Montgomery B., Boyko A., Kutanzi K., Zemp F., Warbritton A.R., Latendresse J.R., Kovalchuk I., Beland F.A., Pogribny I.P. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle 2007, 6:2010-2018.
22. Krichevsky A.M., Gabriely G. miR-21: a small multifaceted RNA. J. Cell. Mol. Med. 2009, 13:39-53.
23. Kumamoto K., Spillare E.A., Fujita K., Horikawa I., Yamashita T., Appella E., Nagashima M., Takenoshita S., Yokota J., Harris C.C. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 2008, 68:3193-3203.
24. Lu Z., Liu M., Stribinskis V., Klinge C.M., Ramos K.S., Colburn N.H., Li Y. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 2008, 27:4373-4379.
25. Matthews E.J., Spalding J.W., Tennant R.W. Transformation of BALB/c 3T3 cells: IV Rank ordered potency of 24 chemical responses detected in a sensitive new procedure. Environ. Health Perspect. 1993, 101:319-345.
26. Melkamu T., Zhang X., Tan J., Zeng Y., Kassie F. Alteration of microRNA expression in vinyl-carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 2010, 31:252-258.
27. Meng F., Henson R., Wehbe-Janek H., Ghoshal K., Jacob S.T., Patel T. MicroRNA-21regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007, 133:647-658.
28. Mirnezami A.H., Pickard K., Zhang L., Primrose J.N., Packham G. MicroRNAs: key players in carcinogenesis and novel therapeutic targets. Eur. J. Surg. Oncol. 2009, 35:339-347.
29. Parkin D.M. The global health burden of infect ion-associated cancers in the year 2002. Int. J. Cancer 2006, 118:3030-3044.
30. Pogribny I.P., Tryndyak V.P., Boyko A., Rodriguez-Juarez R., Beland F.A., Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutat. Res. 2007, 619:30-37.
31. Pogribny I.P. MicroRNA dysregulation during chemical carcinogenesis. Epigenomics 2009, 1:281-290.
32. Raphael K.R., Sabu M., Kumar K.H., Kuttan R. Inhibition of N-methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pac. J. Cancer Prev. 2006, 7:299-302.
33. Risch H.A. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J. Nat. Cancer Inst. 2003, 95:948-960.
34. Sayed D., He M., Hong C., Gao S., Rane S., Yang Z., Abdellatif M. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J. Biol. Chem. 2010, 285:20281-20290.
35. Sedgwick B., Bates P.A., Paik J., Jacobs S.C., Lindahl T. Repair of alkylated DNA: recent advances. DNA Repair 2007, 6:429-442.
36. Selcuklu S.D., Donoghue M.T., Spillane C. miR-21 as a key regulator of oncogenic processes. Biochem. Soc. Trans. 2009, 37:918-925.
37. Takezaki T., Gao C.M., Wu J.Z., Ding J.H., Liu Y.T., Zhang Y., Li S.P., Su P., Liu T.K., Tajima K. Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a highepidemic area. Jpn. J. Cancer Res. 2001, 92:1157-1165.
38. Tricker A.R., Preussmann R. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat. Res. 1991, 259:277-289.
39. Volinia S., Calin G.A., Liu C.G., Ambs S., Cimmino A., Petrocca F., Visone R., Iorio M., Roldo C., Ferracin M., Prueitt R.L., Yanaihara N., Lanza G., Scarpa A., Vecchione A., Negrini M., Harris C.C., Croce C.M. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U S A 2006, 103:2257-2261.
40. Wyatt M.D., Pittman D.L. Methylating agents and DNA repair responses: methylated bases and sources of strand breaks. Chem. Res. Toxicol. 2006, 19:1580-1594.
41. Yang Q., Jie Z., Cao H., Greenle e A.R., Yang C., Zou F., Jiang Y. Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis 2011, 32:713-722.
42. Yang Q., Jie Z., Ye S., Li Z., Han Z., Wu J., Yang C., Jiang Y. Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility. Oncogene 2014, 33:193-202.
43. Yu X., Song H., Xia T., Han S., Xiao B., Luo L., Xi Y., Guo J. Growth inhibitory effects of three miR-129 family members on gastric cancer. Gene 2013, 532:87-93.
44. Zhao H., Li M., Li L., Yang X., Lan G., Zhang Y. MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion, and promotes apoptosis. PLoS One 2013, 8:e83571.
45. Zhu S., Si M.L., Wu H., Mo Y.Y. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J. Biol. Chem. 2007, 282:14328-14336.