Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 1, 2014, Pages 107-113

  De Smet, Lieselotte ^a   Saerens, Lien ^a   De Beer, Thomas ^a   Carleer, Robert ^b   Adriaensens, Peter ^b   Van Bocxlaer, Jan ^a   Vervaet, Chris ^a   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

Author keywords

Cocrystals; Dicarboxylic acids; Itraconazole; Nanosuspension; Poorly water soluble drugs; Wet milling

Indexed keywords

ADIPIC ACID; GLUTARIC ACID; ITRACONAZOLE; MALEIC ACID; NANOCOCRYSTAL; NANOPARTICLE; POLYSORBATE 80; SUCCINIC ACID; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; DRUG CARRIER;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; SOLID STATE; SPRAY DRYING; THERMAL ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; CRYSTALLIZATION; INFRARED SPECTROSCOPY; RAMAN SPECTROMETRY; SURFACE PROPERTY; X RAY DIFFRACTION;

ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL AVAILABILITY; CRYSTALLIZATION; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG LIBERATION; ITRACONAZOLE; MALE; NANOPARTICLES; PARTICLE SIZE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS, RAMAN; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 84901595027     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.12.016     Document Type: Article

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