Association between serum organochlorines and global methylation level of leukocyte DNA among Japanese women: A cross-sectional study

Science of the Total Environment

Volumn 490, Issue , 2014, Pages 603-609

  Itoh, Hiroaki ^a   Iwasaki, Motoki ^b   Kasuga, Yoshio ^c   Yokoyama, Shiro ^d   Onuma, Hiroshi ^d   Nishimura, Hideki ^e   Kusama, Ritsu ^f   Yoshida, Teruhiko ^g   Yokoyama, Kazuhito ^a   Tsugane, Shoichiro ^b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER   (Japan)

^c Nagano Matsushiro General Hospital   (Japan)

^d NAGANO RED CROSS HOSPITAL   (Japan)

^e Nagano Municipal Hospital   (Japan)

^f Hokushin General Hospital   (Japan)

^g NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

DNA methylation; Epidemiology; Epigenetics; Persistent organic pollutants; Polychlorinated biphenyl

Indexed keywords

BODY FLUIDS; DISEASES; DNA; DRUG PRODUCTS; EPIDEMIOLOGY; GAS CHROMATOGRAPHY; ISOTOPES; LINEAR REGRESSION; MASS SPECTROMETRY; METHYLATION; ORGANIC POLLUTANTS; POLYCHLORINATED BIPHENYLS;

DICHLORODIPHENYLTRICHLOROETHANE; DNA METHYLATION; ENVIRONMENTAL POLLUTANTS; EPIGENETICS; HIGH RESOLUTION MASS SPECTROMETRY; MULTI-VARIABLE LINEAR REGRESSION; PERSISTENT ORGANIC POLLUTANT (POP); POLYCHLORINATED BIPHENYL (PCBS);

ALKYLATION;

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; BETA HEXACHLOROCYCLOHEXANE; CELL DNA; CHLORPHENOTANE; HEXACHLOROBENZENE; MIREX; NONACHLOR; ORGANOCHLORINE DERIVATIVE; OXYCHLORDANE; PARA,PARA' DICHLORODIPHENYLTRICHLOROETHANE, PARA PARA' DICHLORODIPHENYLDICHLOROETHYLENE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED BIPHENYL 114; POLYCHLORINATED BIPHENYL 17; POLYCHLORINATED BIPHENYL 183; POLYCHLORINATED BIPHENYL 52; POLYCHLORINATED BIPHENYL 69; POLYCHLORINATED BIPHENYL 74; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG; CHLORINATED HYDROCARBON; POLLUTANT;

BLOOD; CANCER; DDT; DNA; EPIDEMIOLOGY; METHYLATION; ORGANIC POLLUTANT; ORGANOCHLORINE; PCB; SERUM; WOMENS HEALTH;

ADULT; AGED; ARTICLE; BREAST CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA METHYLATION; DNA METHYLATION ASSAY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOTOPE DILUTION ASSAY; JAPANESE (PEOPLE); LEUKOCYTE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; ANALYSIS; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGY; JAPAN; METABOLISM; MIDDLE AGED; PHYSIOLOGY; POLLUTANT; POLLUTION; STATISTICS AND NUMERICAL DATA; TOXICITY;

JAPAN;

ADULT; CROSS-SECTIONAL STUDIES; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; ENVIRONMENTAL POLLUTION; EPIDEMIOLOGIC STUDIES; FEMALE; HUMANS; HYDROCARBONS, CHLORINATED; JAPAN; LEUKOCYTES; MIDDLE AGED;

EID: 84901490615     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2014.05.035     Document Type: Article

References (25)

1. Collotta M., Bertazzi P.A., Bollati V. Epigenetics and pesticides. Toxicology 2013, 307:35-41.
2. Foley D.L., Craig J.M., Morley R., Olsson C.A., Dwyer T., Smith K., et al. Prospects for epigenetic epidemiology. Am J Epidemiol 2009, 169:389-400.
3. IARC List of classifications by Group (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Available:, [accessed August 23 2013]. http://monographs.iarc.fr/ENG/Classification/index.php.
4. Ishihara J., Inoue M., Kobayashi M., Tanaka S., Yamamoto S., Iso H., et al. Impact of the revision of a nutrient database on the validity of a self-administered food frequency questionnaire (FFQ). J Epidemiol 2006, 16:107-116.
5. Itoh H., Iwasaki M., Hanaoka T., Kasuga Y., Yokoyama S., Onuma H., et al. Serum organochlorines and breast cancer risk in Japanese women: a case-control study. Cancer Causes Control 2009, 20:567-580.
6. Iwasaki M., Ono H., Kuchiba A., Kasuga Y., Yokoyama S., Onuma H., et al. Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women. BMC Cancer 2012, 12:323.
7. Karimi M., Johansson S., Ekstrom T.J. Using LUMA: a Luminometric-based assay for global DNA-methylation. Epigenetics 2006, 1:45-48.
8. Karimi M., Johansson S., Stach D., Corcoran M., Grander D., Schalling M., et al. LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res 2006, 312:1989-1995.
9. Kim K.Y., Kim D.S., Lee S.K., Lee I.K., Kang J.H., Chang Y.S., et al. Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environ Health Perspect 2010, 118:370-374.
10. Konishi Y., Kitagawa M., Akutsu K., Tanaka Y. Surveillance of polychlorinated biphenyl congeneric patterns in human breast milk from 1973 to 2000 in Osaka, Japan. Environ Health Prev Med 2006, 11:38-44.
11. Konishi Y., Kuwabara K., Hori S. Continuous surveillance of organochlorine compounds in human breast milk from 1972 to 1998 in Osaka, Japan. Arch Environ Contam Toxicol 2001, 40:571-578.
12. Lind L., Penell J., Luttropp K., Nordfors L., Syvanen A.C., Axelsson T., et al. Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population. Environ Int 2013, 59:456-461.
13. Milbrath M.O., Wenger Y., Chang C.W., Emond C., Garabrant D., Gillespie B.W., et al. Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding. Environ Health Perspect 2009, 117:417-425.
14. Ono H., Iwasaki M., Kuchiba A., Kasuga Y., Yokoyama S., Onuma H., et al. Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA. Cancer Sci 2012, 103:2159-2164.
15. Phillips D.L., Pirkle J.L., Burse V.W., Bernert J.T., Henderson L.O., Needham L.L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol 1989, 18:495-500.
16. Rusiecki J.A., Baccarelli A., Bollati V., Tarantini L., Moore L.E., Bonefeld-Jorgensen E.C. Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect 2008, 116:1547-1552.
17. Sutherland J.E., Costa M. Epigenetics and the environment. Ann N Y Acad Sci 2003, 983:151-160.
18. The Council for Science and Technology; Ministry of Education, Culture, Sports, Science and Technology J. Standard Tables of Food Composition in Japan 2005, National Printing Bureau. the fifth revised and enlarged edition.
19. Tsubono Y., Takamori S., Kobayashi M., Takahashi T., Iwase Y., Iitoi Y., et al. A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan. J Epidemiol 1996, 6:45-53.
20. Tsukino H., Hanaoka T., Sasaki H., Motoyama H., Hiroshima M., Tanaka T., et al. Fish intake and serum levels of organochlorines among Japanese women. Sci Total Environ 2006, 359:90-100.
21. Willett W.C., Howe G.R., Kushi L.H. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997, 5:1220S-1228S. (discussion 1229S-1231S).
22. Wilson A.S., Power B.E., Molloy P.L. DNA hypomethylation and human diseases. Biochim Biophys Acta 2007, 1775:138-162.
23. Woo H.D., Kim J. Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis. PLoS ONE 2012, 7:e34615.
24. Zhang X., Ho S.M. Epigenetics meets endocrinology. J Mol Endocrinol 2011, 46:R11-R32.
25. Zhu Z.Z., Hou L., Bollati V., Tarantini L., Marinelli B., Cantone L., et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol 2012, 41:126-139.