Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Iwasaki, Motoki ^a   Ono, Hiroe ^b,c   Kuchiba, Aya ^b,d   Kasuga, Yoshio ^e   Yokoyama, Shiro ^f   Onuma, Hiroshi ^f   Nishimura, Hideki ^g   Kusama, Ritsu ^h   Yoshida, Teruhiko ^b   Tsugane, Shoichiro ^a  

^a NATIONAL CANCER CENTER   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e Nagano Matsushiro General Hospital   (Japan)

^f NAGANO RED CROSS HOSPITAL   (Japan)

^g Nagano Municipal Hospital   (Japan)

^h Nagano Hokushin General Hospital   (Japan)

Author keywords

Cross sectional study; Endogenous sex hormones; Global methylation level; Luminometric methylation assay; Peripheral blood leukocyte DNA

Indexed keywords

AMMONIUM SULFATE; ANDROSTENEDIONE; ESTRADIOL; ESTRONE; GENOMIC DNA; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; BREAST CANCER; CASE CONTROL STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA METHYLATION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; IMMUNORADIOMETRIC ASSAY; JAPAN; JAPANESE; LEUKOCYTE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRECIPITATION; RADIOIMMUNOASSAY;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CROSS-SECTIONAL STUDIES; DNA METHYLATION; FEMALE; GONADAL STEROID HORMONES; HUMANS; JAPAN; LEUKOCYTES; MIDDLE AGED; POSTMENOPAUSE; RISK FACTORS;

EID: 84864182394     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-323     Document Type: Article

References (30)

1. Esteller M. Epigenetics in cancer. N Engl J Med 2008, 358(11):1148-1159. 10.1056/NEJMra072067, 18337604.
2. Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301(5895):89-92. 10.1038/301089a0, 6185846.
3. Brooks J, Cairns P, Zeleniuch-Jacquotte A. Promoter methylation and the detection of breast cancer. Cancer Causes Control 2009, 20(9):1539-1550. 10.1007/s10552-009-9415-y, 2885278, 19768562.
4. Jovanovic J, Ronneberg JA, Tost J, Kristensen V. The epigenetics of breast cancer. Mol Oncol 2010, 4(3):242-254. 10.1016/j.molonc.2010.04.002, 20627830.
5. Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2007, 16(1):108-114. 10.1158/1055-9965.EPI-06-0636, 17220338.
6. Moore LE, Pfeiffer RM, Poscablo C, Real FX, Kogevinas M, Silverman D, Garcia-Closas R, Chanock S, Tardon A, Serra C, et al. Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol 2008, 9(4):359-366. 10.1016/S1470-2045(08)70038-X, 2601672, 18339581.
7. Widschwendter M, Apostolidou S, Raum E, Rothenbacher D, Fiegl H, Menon U, Stegmaier C, Jacobs IJ, Brenner H. Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PLoS One 2008, 3(7):e2656. 10.1371/journal.pone.0002656, 2442168, 18628976.
8. Choi JY, James SR, Link PA, McCann SE, Hong CC, Davis W, Nesline MK, Ambrosone CB, Karpf AR. Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis 2009, 30(11):1889-1897. 10.1093/carcin/bgp143, 2783000, 19584139.
9. Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, Yang AS, Vokonas P, Lissowska J, Fustinoni S, et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol 2012, 41(1):126-139. 10.1093/ije/dyq154, 20846947.
10. Foley DL, Craig JM, Morley R, Olsson CA, Dwyer T, Smith K, Saffery R. Prospects for epigenetic epidemiology. Am J Epidemiol 2009, 169(4):389-400. 3290967, 19139055.
11. Textbood of Cancer Epidemiology, Second Edition 2008, New York: Oxford University Press, Adami HO, Hunter DJ, Trichopolos D.
12. Key TJ, Verkasalo PK, Banks E. Epidemiology of breast cancer. Lancet Oncol 2001, 2(3):133-140. 10.1016/S1470-2045(00)00254-0, 11902563.
13. Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002, 94(8):606-616. 10.1093/jnci/94.8.606, 11959894.
14. Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer 2009, 61(4):447-456. 10.1080/01635580802610123, 19838916.
15. Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, et al. Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Cancer Sci 2009, 100(5):927-933. 10.1111/j.1349-7006.2009.01118.x, 19298602.
16. Tsubono Y, Takamori S, Kobayashi M, Takahashi T, Iwase Y, Iitoi Y, Akabane M, Yamaguchi M, Tsugane S. A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan. J Epidemiol 1996, 6(1):45-53. 10.2188/jea.6.45, 8795957.
17. Ishihara J, Inoue M, Kobayashi M, Tanaka S, Yamamoto S, Iso H, Tsugane S. Impact of the revision of a nutrient database on the validity of a self-administered food frequency questionnaire (FFQ). J Epidemiol 2006, 16(3):107-116. 10.2188/jea.16.107, 16710079.
18. The Council for Science and Technology; Ministry of Education Culture, Sports, Science and Technology, Japan Standard Tables of Food Composition in Japan, the fifth revised and enlarged edition 2005, Tokyo: National Printing Bureau, The Council for Science and Technology; Ministry of Education Culture, Sports, Science and Technology, Japan.
19. Iwasaki M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Hamada GS, Nishimoto IN, Maciel Mdo S, Motola J, et al. Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians. BMC Med 2011, 9:16. 10.1186/1741-7015-9-16, 3050759, 21324183.
20. Karimi M, Johansson S, Stach D, Corcoran M, Grander D, Schalling M, Bakalkin G, Lyko F, Larsson C, Ekstrom TJ. LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res 2006, 312(11):1989-1995. 10.1016/j.yexcr.2006.03.006, 16624287.
21. Karimi M, Johansson S, Ekstrom TJ. Using LUMA: a Luminometric-based assay for global DNA-methylation. Epigenetics 2006, 1(1):45-48. 10.4161/epi.1.1.2587, 17998810.
22. Willett WC. Nutritional Epidemiology 1998, New York: Oxford University Press, 2.
23. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986, 124(1):17-27.
24. Li S, Hansman R, Newbold R, Davis B, McLachlan JA, Barrett JC. Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus. Mol Carcinog 2003, 38(2):78-84. 10.1002/mc.10147, 14502647.
25. Li S, Washburn KA, Moore R, Uno T, Teng C, Newbold RR, McLachlan JA, Negishi M. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res 1997, 57(19):4356-4359.
26. Rusiecki JA, Baccarelli A, Bollati V, Tarantini L, Moore LE, Bonefeld-Jorgensen EC. Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect 2008, 116(11):1547-1552. 10.1289/ehp.11338, 2592276, 19057709.
27. Hillman RS, Steinberg SE. The effects of alcohol on folate metabolism. Annu Rev Med 1982, 33:345-354. 10.1146/annurev.me.33.020182.002021, 6805415.
28. Eichner ER, Hillman RS. Effect of alcohol on serum folate level. J Clin Invest 1973, 52(3):584-591. 10.1172/JCI107219, 302296, 4630980.
29. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10(1):111-113. 10.1038/ng0595-111, 7647779.
30. van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet 1998, 62(5):1044-1051. 10.1086/301825, 1377082, 9545395.