Genome-wide analysis of selection on the malaria parasite plasmodium falciparum in West African populations of differing infection endemicity

Molecular Biology and Evolution

Volumn 31, Issue 6, 2014, Pages 1490-1499

  Mobegi, Victor A ^a,b   Duffy, Craig W ^a   Amambua Ngwa, Alfred ^b   Loua, Kovana M ^c   Laman, Eugene ^c   Nwakanma, Davis C ^b   MacInnis, Bronwyn ^d   Aspeling Jones, Harvey ^a   Murray, Lee ^a   Clark, Taane G ^a   Kwiatkowski, Dominic P ^d,e   Conway, David J ^a,b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c National Institute of Public Health   (Guinea)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

balancing selection; directional selection; immunity; pathogen; population genomics; transmission

Indexed keywords

ANTIMALARIAL AGENT;

ADAPTIVE IMMUNITY; ARTICLE; BALANCING SELECTION; CONTROLLED STUDY; ENDEMIC DISEASE; GAMBIA; GAMETOCYTE; GDV1 GENE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GUINEA; MALARIA FALCIPARUM; MEROZOITE; NONHUMAN; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; SEASONAL VARIATION; SINGLE NUCLEOTIDE POLYMORPHISM; AFRICA; CHILD; CLASSIFICATION; DNA SEQUENCE; GENETIC SELECTION; GENETICS; HAPLOTYPE; HUMAN; INFANT; METAGENOMICS; PARASITOLOGY; PRESCHOOL CHILD;

AFRICA, WESTERN; CHILD; CHILD, PRESCHOOL; ENDEMIC DISEASES; GENE FREQUENCY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; INFANT; MALARIA, FALCIPARUM; METAGENOMICS; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84901474677     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu106     Document Type: Article

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