Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection

Journal of Infectious Diseases

Volumn 209, Issue 7, 2014, Pages 1126-1135

  Nwakanma, Davis C ^a   Duffy, Craig W ^b   Amambua Ngwa, Alfred ^a   Oriero, Eniyou C ^a   Bojang, Kalifa A ^a   Pinder, Margaret ^a   Drakeley, Chris J ^b   Sutherland, Colin J ^b   Milligan, Paul J ^b   Macinnis, Bronwyn ^c   Kwiatkowski, Dominic P ^c,d   Clark, Taane G ^b   Greenwood, Brian M ^b   Conway, David J ^a,b  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

archival analysis; genomic surveillance; policy and practice; population genetics; resistance monitoring

Indexed keywords

CHLOROQUINE; PYRIMETHAMINE; SULFADOXINE;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CRT GENE; DHFR GENE; DHPS GENE; GAMBIA; GENE FREQUENCY; GENE LOCUS; GENOMICS; GENOTYPE; MDR1 GENE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARCHIVAL ANALYSIS; GENOMIC SURVEILLANCE; POLICY AND PRACTICE; POPULATION GENETICS; RESISTANCE MONITORING;

ALLELES; ANTIMALARIALS; DNA, PROTOZOAN; DRUG RESISTANCE; GAMBIA; GENOME, PROTOZOAN; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84898860071     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jit618     Document Type: Article

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