Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model

Cancer Letters

Volumn 349, Issue 2, 2014, Pages 120-127

  Borriello, Lucia ^a   Montès, Matthieu ^b   Lepelletier, Yves ^c,d,e   Leforban, Bertrand ^a   Liu, Wang Qing ^a   Demange, Luc ^a   Delhomme, Brigitte ^e   Pavoni, Serena ^a   Jarray, Rafika ^a   Boucher, Jean Luc ^a   Dufour, Sylvie ^f   Hermine, Olivier ^c,d,e   Garbay, Christiane ^a   Hadj Slimane, Réda ^g   Raynaud, Françoise ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Bioinformatique et Chimie Moléculaire   (France)

^c INSERM   (France)

^d PARIS DESCARTES SORBONNE PARIS CITÉ UNIVERSITY   (France)

^e CNRS   (France)

^f INSTITUT CURIE   (France)

^g Tragex Pharma   (France)

Author keywords

Fully organic inhibitors; Neuropilin; Protein protein interaction; Tumor growth inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; CD31 ANTIGEN; CD34 ANTIGEN; KI 67 ANTIGEN; NEUROPILIN; NEUROPILIN 1; NEUROPILIN 2; NEUROPILIN ANTAGONIST; UNCLASSIFIED DRUG; VASCULOTROPIN A; LIGAND; MOLECULAR LIBRARY; PEPTIDE FRAGMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A (138-165);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MODEL; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE COURSE; DRUG EFFECTS; FEMALE; METABOLISM; MOLECULAR DOCKING; MOLECULAR LIBRARY; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHARMACOLOGY; SCID MOUSE; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; TUMOR CELL LINE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DISEASE PROGRESSION; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIGANDS; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NEUROPILINS; PEPTIDE FRAGMENTS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901456316     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.04.004     Document Type: Article

References (28)

1. He Z., Tessier-Lavigne M. Cell 1997, 90:739-751.
2. Bielenberg D.R., Pettaway C.A., Takashima S., Klagsbrun M. Exp. Cell Res. 2006, 312:584-593.
3. Barr M.P., Byrne A.M., Duffy A.M., Condron C.M., Devocelle M., Harriott P., Bouchier-Hayes D.J., Harmey J.H. Br. J. Cancer 2005, 92:328-333.
4. Prud'homme G.J., Glinka Y. Oncotarget 2012, 3:921-939.
5. Wild J.R., Staton C.A., Chapple K., Corfe B.M. Int. J. Exp. Pathol. 2012, 93:81-103.
6. Pan Q., Chanthery Y., Liang W.C., Stawicki S., Mak J., Rathore N., Tong R.K., Kowalski J., Yee S.F., Pacheco G., Ross S., Cheng Z., Le Couter J., Plowman G., Peale F., Koch A.W., Wu Y., Bagri A., Tessier-Lavigne M., Watts R.J. Cancer Cell 2007, 11:53-67.
7. Xin Y., Bai S., Damico-Beyer L.A., Jin D., Liang W.C., Wu Y., Theil F.P., Joshi A., Lu Y., Lowe J., Maia M., Brachmann R.K., Xiang H. Pharm. Res. 2012, 29:2512-2521.
8. Caunt M., Mak J., Liang W.C., Stawicki S., Pan Q., Tong R.K., Kowalski J., Ho C., Reslan H.B., Ross J., Berry L., Kasman I., Zlot C., Cheng Z., Le Couter J., Filvaroff E.H., Plowman G., Peale F., French D., Carano R., Koch A.W., Wu Y., Watts R.J., Tessier-Lavigne M., Bagri A. Cancer Cell 2008, 13:331-342.
9. Nowak D.G., Woolard J., Amin E.M., Konopatskaya O., Saleem M.A., Churchill A.J., Ladomery M.R., Harper S.J., Bates D.O. J. Cell Sci. 2008, 121:3487-3495.
10. Perret G.Y., Starzec A., Hauet N., Vergote J., Le Pecheur M., Vassy R., Leger G., Verbeke K.A., Bormans G., Nicolas P., Verbruggen A.M., Moretti J.L. Nucl. Med. Biol. 2004, 31:575-581.
11. Starzec A., Ladam P., Vassy R., Badache S., Bouchemal N., Navaza A., du Penhoat C.H., Perret G.Y. Peptides 2007, 28:2397-2402.
12. Novoa A., Pellegrini-Moise N., Bechet D., Barberi-Heyob M., Chapleur Y. Bioorg. Med. Chem. 2010, 18:3285-3298.
13. Parker M.W., Xu P., Li X., Vander Kooi C.W. J. Biol. Chem. 2012.
14. Jia H., Bagherzadeh A., Hartzoulakis B., Jarvis A., Lohr M., Shaikh S., Aqil R., Cheng L., Tickner M., Esposito D., Harris R., Driscoll P.C., Selwood D.L., Zachary I.C. J. Biol. Chem. 2006, 281:13493-13502.
15. Jarvis A., Allerston C.K., Jia H., Herzog B., Garza-Garcia A., Winfield N., Ellard K., Aqil R., Lynch R., Chapman C., Hartzoulakis B., Nally J., Stewart M., Cheng L., Menon M., Tickner M., Djordjevic S., Driscoll P.C., Zachary I., Selwood D.L. J. Med. Chem. 2010, 53:2215-2226.
16. Teesalu T., Sugahara K.N., Kotamraju V.R., Ruoslahti E. Proc. Natl. Acad. Sci. USA 2009, 106:16157-16162.
17. Zanuy D., Kotla R., Nussinov R., Teesalu T., Sugahara K.N., Aleman C., Haspel N. J. Struct. Biol. 2013, 182:78-86.
18. Vander Kooi C.W., Jusino M.A., Perman B., Neau D.B., Bellamy H.D., Leahy D.J. Proc. Natl. Acad. Sci. USA 2007, 104:6152-6157.
19. Jain A.N. J. Med. Chem. 2003, 46:499-511.
20. Abagyan R., Totrov M. J. Mol. Biol. 1994, 235:983-1002.
21. Goncalves V., Gautier B., Garbay C., Vidal M., Inguimbert N. Anal. Biochem. 2007, 366:108-110.
22. Ferrara N. Nat. Rev. Cancer 2002, 2:795-803.
23. Jain R.K., Duda D.G., Clark J.W., Loeffler J.S. Nat. Clin. Pract. Oncol. 2006, 3:24-40.
24. Welti J., Loges S., Dimmeler S., Carmeliet P. J. Clin. Invest. 2013, 123:3190-3200.
25. Liang W.C., Dennis M.S., Stawicki S., Chanthery Y., Pan Q., Chen Y., Eigenbrot C., Yin J., Koch A.W., Wu X., Ferrara N., Bagri A., Tessier-Lavigne M., Watts R.J., Wu Y. J. Mol. Biol. 2007, 366:815-829.
26. Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. J. Comput. Chem. 2004, 25:1605-1612.
27. Lagorce D., Sperandio O., Galons H., Miteva M.A., Villoutreix B.O. BMC Bioinform. 2008, 9:396.
28. Allain B., Jarray R., Borriello L., Leforban B., Dufour S., Liu W.Q., Pamonsinlapatham P., Bianco S., Larghero J., Hadj-Slimane R., Garbay C., Raynaud F., Lepelletier Y. Cell Signal 2012, 24:214-223.