The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Ma, Yong Chao ^a   Shi, Chong ^a   Zhang, Yao Nan ^a   Wang, Lan Ge ^a   Liu, Hao ^a   Jia, Hong Ti ^a   Zhang, Yu Xiang ^a   Sarkar, Fazlul H ^b   Wang, Ze Sheng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CSL PROTEIN; DNA BINDING PROTEIN; FURIN; NOTCH1 RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; NOTCH1 PROTEIN, HUMAN; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; PYRIMIDINE DERIVATIVE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CONTROLLED STUDY; FEMALE; GENE; HES 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PANCREAS CANCER; PROMOTER REGION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL NEOPLASM; GENETICS; HELA CELL; METABOLISM; MUTATION; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; TUMOR VOLUME; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; FURIN; HELA CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, CONFOCAL; MUTATION; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-SIS; PYRIMIDINES; RECEPTOR, NOTCH1; SRC-FAMILY KINASES; TRANSFORMING GROWTH FACTOR ALPHA; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

EID: 84859153537     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033414     Document Type: Article

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