Ocular retardation mouse caused by Chx10 homeobox null allele: Impaired retinal progenitor proliferation and bipolar cell differentiation

Nature Genetics

Volumn 12, Issue 4, 1996, Pages 376-384

  Burmeister, Margit ^a,b,c   Novak, Jakub ^d,e   Liang, Mei Ying ^f   Basu, Sharmila ^a,b   Ploder, Lynda ^d   Hawes, Norman L ^g   Vidgen, Danka ^h   Hoover, Frank ^a,b   Goldman, Daniel ^a,b   Kalnins, Vitauts I ^h   Roderick, Thomas H ^g   Taylor, Benjamin A ^g   Hankin, Mark H ^f   McInnes, Roderick R ^d,e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f MEDICAL COLLEGE OF OHIO   (United States)

^g JACKSON LABORATORY   (United States)

^h UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION; HOMEOBOX; MICROPHTHALMIA; MOUSE; NERVE CELL NETWORK; NEUROEPITHELIUM; NONHUMAN; NULL CELL; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; STEM CELL; STOP CODON;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CHROMOSOME MAPPING; DNA; DNA PRIMERS; EYE ABNORMALITIES; FEMALE; GENE EXPRESSION; GENES, HOMEOBOX; HOMOZYGOTE; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; RETINA; STEM CELLS;

EID: 13344249785     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0496-376     Document Type: Article

References (58)

1. Cepko, C. L , Austin, C. P., Yang, X., Alexiades, M. & Ezzeddine, D. Cell fate determination in the vertebrate retina. Proc. Natl. Acad. Sci. USA 93, 589-595 (1996).
2. Hill, R E et al. Mouse small eye results from mutations in a paired-like homeobox- containing gene [published erratum appears in Nature 355, 750 (1992)]. Nature 354:522-525 (1991).
3. Kastner, P. et al. Genetic analysis of RXR alpha developmental function convergence of RXR and RAR signaling pathways in heart and eye morphogenesis Cell 78, 987-1003 (1994).
4. Hui, C. C., Slusarski, D., Platt, K. A., Holmgren, R. & Joyner, A. L. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162, 402-413 (1994).
5. Franz, T. & Besecke, A. The development of the eye in homozygotes of the mouse mutant Extra- toes. Anat. Embryol. 184, 355-361 (1991)
6. Hodgkinson, C. A. et al. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74, 395-404 (1993).
7. Kodama, R. & Eguchi, G. Gene regulation and differentiation in vertebrate ocular tissues Curr Opin. Genet. Dev 4, 703-708 (1994).
8. Halder, G., Callaerts, P. & Gehring, W. J. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792 (1995).
9. Dickson, B. & Hafen, E. Genetic dissection of eye development in Drosophila in The Development of Drosophila Melanogaster (eds Bate, M. & Martines-Arias, A.) 1327-1362 (Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1993).
10. Wolff, T. & Ready, D. Pattern formation in the Drosophila retina in The Development of Drosophila Melanogaster (eds Bate, M. & Martines-Arias, A.) 1277-1325 (Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1993).
11. Truslove, G. M. A gene causing ocular retardation in the mouse. J. Embryol. Exp. Morphol. 10, 652-660 (1962).
12. Theiler, K., Varnum, D S., Nadeau, J. H., Stevens, L. C. & Cagianut, B. A new allele of ocular retardation, early development and morphogenetic cell death. Anat. Embryol. (Berl) 150, 85-97 (1976).
13. Robb, R. M , Silver, J. & Sullivan, R. T. Ocular retardation (or) in the mouse. Invest. Opthalmol Vis Sci. 17, 468-473 (1978).
14. Silver, J. & Robb, R. M Studies on the development of the eye cup and optic nerve in normal mice and in mutants with congenital optic nerve aplasia. Dev. Biol. 68, 175-190 (1979).
15. Liu, I. S et al. Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron 13, 377-393 (1994)
16. Svendsen, P. C. & McGhee, J. D. The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye Development 121, 1253-1262 (1995).
17. Hawes, N. L & Roderick, T. H Linkage of ocular retardation (or). Mouse Genome 87, 93 (1990).
18. Dietrich, W. F. et al. A genetic map of the mouse with 4006 simple sequence length polymorphisms Nature Genet. 7S, 220-245 (1994).
19. Greferath, U., Grunert, U & Wassle, H. Rod bipolar cells in the mammalian retina show protein kinase C-like immunoreactivity. J. Comp. Neurol. 301, 433-442 (1990)
20. Hankin, M. H. & Lagenaur, C. F. Cell adhesion molecules in the early developing mouse retina: retinal neurons show preferential outgrowth in vitro on L1 but not N-CAM. J. Neurobiol. 25, 472-487 (1994).
21. Brittis, P. A., Canning, D. R. & Silver, J. Chondroitin sulfate as a regulator of neuronal patterning in the retina. Science 255, 733-736 (1992).
22. Reh, T. A., Tetzlaff, W., Ertlmaler, A & Zwiers, H. Developmental study of the expression of B50/GAP-43 in rat retina. J. Neurobiol 24, 949-958 (1993).
23. Hoover, F. & Goldman, D. Temporally correlated expression of nAChR genes during development of the mammalian retina Exp. Eye Res. 54, 561-571 (1992)
24. 3. in The Structure of the Eye (ed. Smelser, G. K.) 487-506 (New York, Academic Press, 1961)
25. Young, R W. Cell differentiation in the retina of the mouse. Anat. Rec. 212, 199-205 (1985)
26. Inoue, A , Obata, K. & Akagawa, K. Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1. J. Biol. Chem. 267, 10613-10619 (1992).
27. Barnstable, C. J., Hofstein, R. & Akagawa, K A marker of early amacrine cell development in rat retina Brain Res 352, 286-290 (1985).
28. Drager, U. C , Edwards, D. L & Barnstable, C. J. Antibodies against filamentous components in discrete cell types of the mouse retina. J. Neurosci. 4, 2025-2042 (1984).
29. Barnstable, C. J., Akagawa, K , Hofstein, R. & Horn, J. P. Monoclonal antibodies that label discrete cell types in the mammalian nervous system. Cold Spring Harb Symp Quant. Biol. 2, 863-876 (1983)
30. Bascom, R. A. et al. Cloning of the cDNA for a novel photoreceptor membrane protein (rom- 1) identifies a disk nm protein family implicated in human retinopathies. Neuron 8, 1171-1184 (1992).
31. Barnstable, C. J. Monoclonal antibodies which recognize different cell types in the rat retina. Nature 286, 231-235 (1980).
32. Konyukhov, B V & Sazhina, M. V. Interaction of the genes of ocular retardation and microphthalmia in mice. Folia Biol. (Praha) 12, 116-123 (1966)
33. Konyukhov, B V. & Sazhina, M. V. Inhibition of DNA synthesis in embryonic mouse retina as a result of gene interaction. Dev Biol. 45, 1-6 (1975).
34. Dolle, P. et al. Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441 (1993)
35. Condie, B. G. & Capecchi, M. R. Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development 119, 579-595 (1993).
36. Condie, B. G & Capecchi, M. R. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions [published erratum appears in Nature 371, 537 (1994)]. Nature 370, 304-307 (1994).
37. Duboule, D. Vertebrate Hox genes and proliferation an alternative pathway to homeosis? Curr. Opin. Genet. Dev. 5, 525-528 (1995).
38. Rabbitts, T. H Chromosomal translocations in human cancer. Nature 372, 143-149 (1994).
39. Hentsch, B. et al. Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 10, 70-79 (1996).
40. Graham, A., Francis, W P., Brickell, P. & Lumsden, A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686 (1994)
41. Turner, D. L. & Cepko, C. L. A common progenitor for neurons and glia persists in rat retina late in development. Nature 328, 131-136 (1987).
42. Wetts, R. & Fraser, S. E Multipotent precursors can give rise to all major cell types of the frog retina. Science 239, 1142-1145 (1988).
43. Holt, C. E., Bertsch, T. W., Ellis, H. M. & Harris, W. A. Cellular determination in the Xenopus retina is independent of lineage and birth date. Neuron 1, 15-26 (1988).
44. Stoykova, A. & Gruss, P Roles of Pax-Genes in Developing and Adult Brain as Suggested by Expression Patterns. J. Neuroscience 14, 1395-1412 (1994).
45. Strachan, T. & Read, A. P. PAX genes. Curr. Opin. Genet. Dev. 4, 427-438 (1994).
46. Taylor, B. A. & Rowe, L. A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome. Genomics 5, 221-232 (1989)
47. Taylor, B. A., Reifsnyder, P. C. & DiLauro, R. Linkage of the thyroid peroxidase locus (Tpo) to markers in the proximal part of chromosome 12 of the mouse Cytogenet. Cell Genet. 60, 250-251 (1992).
48. Taylor, B. A , Bailey, D. W., Cherry, M., Riblet, R. & Weigert, M. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature 256, 644-645 (1975).
49. Ikeda, H., Laigret, F., Martin, M. A & Repaske, R. Characterization of a molecularly cloned retroviral sequence associated with Fv-4 resistance. J. Virol. 55, 768-777 (1985).
50. Taylor, R G., Grieco, D., Clarke, G. A , McInnes, R. R. & Taylor, B. A. Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10. Genomics 16, 231-240 (1993)
51. Hawes, N. L., Langley, S H & Roderick, T. H. Location of syndactylism (sm) on chr. 12. Mouse News Lett. 63, 20 (1980).
52. Kosambi, D. D. The estimation of map distances from recombination values Ann Eugen. 12, 172-175 (1944).
53. Soriano, E., Del, R. J., Martinez, G F , Ferrer, I. & Lopez, C. Immunocytochemical detection of 5′-bromodeoxyuridine in fluoro-gold- labelled neurons: a simple technique to combine retrograde axonal tracing and neurogenetic characterization of neurons. J. Histochem Cytochem. 39, 1565-1570 (1991).
54. Humason, G. L. Animal Tissue Techniques. (San Francisco, W.H. Freeman & Co., 1979).
55. Shaw, G & Weber, K. The intermediate filament complement of the retina: a comparison between different mammalian species Eur. J. Cell. Biol. 33, 95-104 (1984).
56. Erickson, P. A., Fisher, S K., Guerin, C J., Anderson, D. H & Kaska, D. D. Glial fibrillary acidic protein increases in Muller cells after retinal detachment. Exp. Eye Res. 44, 37-48 (1987).
57. Linser, P. & Moscona, A. A. Carbonic anhydrase C in the neural retina: transition from generalized to glia-specific cell localization during embryonic development. Proc. Natl. Acad Sci. USA 78, 7190-7194 (1981)
58. Adams, J. C. Heavy metal intensification of DAB-based HRP reaction product. J. Histochem. Cytochem. 29, 775 (1981).