PH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins

International Journal of Pharmaceutics

Volumn 471, Issue 1-2, 2014, Pages 83-91

  Koetting, Michael C ^a   Peppas, Nicholas A ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Ionic strength; Isoelectric point; Itaconic acid; Oral drug delivery; pH Responsive hydrogels; Protein therapeutics

Indexed keywords

1 VINYL 2 PYRROLIDINONE; BUFFER; CALCITONIN; ITACONIC ACID; METHACRYLIC ACID; SALCATONIN; 2 PYRROLIDONE DERIVATIVE; DRUG CARRIER; HYDROGEL; POLY(ITACONIC ACID-CO-N-VINYLPYRROLIDONE); POLYMER; SOLUTION AND SOLUBILITY;

ARTICLE; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HYDROGEL; IONIC STRENGTH; ISOELECTRIC POINT; PH; PRIORITY JOURNAL; SOLUTION AND SOLUBILITY; SWELLING; CACO 2 CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; ORAL DRUG ADMINISTRATION; OSMOLARITY; TOXICITY;

ADMINISTRATION, ORAL; CACO-2 CELLS; CALCITONIN; CELL SURVIVAL; DRUG CARRIERS; DRUG LIBERATION; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; ISOELECTRIC POINT; OSMOLAR CONCENTRATION; POLYMERS; PYRROLIDINONES; SOLUTIONS;

EID: 84901439182     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.023     Document Type: Article

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