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Volumn 30, Issue 5, 2004, Pages 497-504

Effect of poly (ethylene glycol) molecular weight and microparticle size on oral insulin delivery from P(MAA-g-EG) microparticles

Author keywords

Controlled drug release; Oral insulin delivery; P(MAA g EG) microparticles; PEG; pH swelling behavior

Indexed keywords

COPOLYMER; INSULIN; MACROGOL; POLYMETHACRYLIC ACID DERIVATIVE;

EID: 1842868901     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120037480     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 0030460690 scopus 로고    scopus 로고
    • Oral controlled release technology for peptides: Status and future prospects
    • Fix, J.A. Oral controlled release technology for peptides: status and future prospects. Pharm. Res. 1996, 13, 1760-1764.
    • (1996) Pharm. Res. , vol.13 , pp. 1760-1764
    • Fix, J.A.1
  • 2
    • 0035858290 scopus 로고    scopus 로고
    • Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications
    • Bures, P.; Huang, Y.; Oral, E.; Peppas, N.A. Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications. J. Control. Release 2001, 72, 25-33.
    • (2001) J. Control. Release , vol.72 , pp. 25-33
    • Bures, P.1    Huang, Y.2    Oral, E.3    Peppas, N.A.4
  • 4
    • 0347291781 scopus 로고    scopus 로고
    • Synthesis and characterization of pH-responsive nanosized hydrogels of poly(methacrylic acid-g-ethylene glycol) for oral peptide delivery
    • Barratt, G., Duchêne, D., Fattal, F., Legendre, J.Y., Eds.; Editions de Santé: Paris
    • Ichikawa, H.; Peppas, N.A. Synthesis and characterization of pH-responsive nanosized hydrogels of poly(methacrylic acid-g-ethylene glycol) for oral peptide delivery. In New Trends in Polymers for Oral and Parenteral Administration: From Design to Receptors; Barratt, G., Duchêne, D., Fattal, F., Legendre, J.Y., Eds.; Editions de Santé: Paris, 2001; 261-264.
    • (2001) New Trends in Polymers for Oral and Parenteral Administration: From Design to Receptors , pp. 261-264
    • Ichikawa, H.1    Peppas, N.A.2
  • 5
    • 0037161338 scopus 로고    scopus 로고
    • Physicochemical behavior and cytotoxic effects of P(MAA-g-EG) nanospheres for oral delivery of proteins
    • Torres-Lugo, M.; Garcia, M.; Record, R.; Peppas, N.A. Physicochemical behavior and cytotoxic effects of P(MAA-g-EG) nanospheres for oral delivery of proteins. J. Control. Release 2002, 80, 197-205.
    • (2002) J. Control. Release , vol.80 , pp. 197-205
    • Torres-Lugo, M.1    Garcia, M.2    Record, R.3    Peppas, N.A.4
  • 7
    • 0032962321 scopus 로고    scopus 로고
    • A model-based algorithm for blood glucose control in type I diabetic patients
    • Parker, R.S.; Doyle, F.J., III; Peppas, N.A. A model-based algorithm for blood glucose control in type I diabetic patients. IEEE Trans. Biomed. Eng. 1999, 46, 148-157.
    • (1999) IEEE Trans. Biomed. Eng. , vol.46 , pp. 148-157
    • Parker, R.S.1    Doyle III, F.J.2    Peppas, N.A.3
  • 8
    • 0034525582 scopus 로고    scopus 로고
    • Robust control in diabetes using a physiological model
    • Parker, R.S.; Ward, J.H.; Doyle, F.J., III; Peppas, N.A. Robust control in diabetes using a physiological model. AIChE J. 2000, 46, 2537-2549.
    • (2000) AIChE J. , vol.46 , pp. 2537-2549
    • Parker, R.S.1    Ward, J.H.2    Doyle III, F.J.3    Peppas, N.A.4
  • 9
    • 0029930650 scopus 로고    scopus 로고
    • Modulation of drug permeation through interpolymer complexed hydrogels for drug delivery applications
    • Bell, C.L.; Peppas, N.A. Modulation of drug permeation through interpolymer complexed hydrogels for drug delivery applications. J. Control. Release 1996, 39, 201-207.
    • (1996) J. Control. Release , vol.39 , pp. 201-207
    • Bell, C.L.1    Peppas, N.A.2
  • 10
    • 0031213203 scopus 로고    scopus 로고
    • Analysis of the complexation/decomplexation phenomena in graft copolymer networks
    • Lowman, A.M.; Peppas, N.A. Analysis of the complexation/decomplexation phenomena in graft copolymer networks. Macromolecules 1997, 30, 4959-4965.
    • (1997) Macromolecules , vol.30 , pp. 4959-4965
    • Lowman, A.M.1    Peppas, N.A.2
  • 11
    • 0033990425 scopus 로고    scopus 로고
    • Molecular analysis of interpolymer complexation in graft copolymer networks
    • Lowman, A.M.; Peppas, N.A. Molecular analysis of interpolymer complexation in graft copolymer networks. Polymer 2000, 41, 73-80.
    • (2000) Polymer , vol.41 , pp. 73-80
    • Lowman, A.M.1    Peppas, N.A.2
  • 13
    • 0346661499 scopus 로고    scopus 로고
    • Biointeractions of pH-sensitive poly(methacrylic acid-g-ethylene glycol) hydrogel microspheres with the Caco-2 model cell line
    • Barratt, G., Duchêne, D., Fattal, F., Legendre, J.Y., Eds.; Editions de Santé: Paris
    • Garcia, M.; Torres-Lugo, M.; Alonso, M.J.; Peppas, N.A. Biointeractions of pH-sensitive poly(methacrylic acid-g-ethylene glycol) hydrogel microspheres with the Caco-2 model cell line. In New Trends in Polymers for Oral and Parenteral Administration: from Design to Receptors; Barratt, G., Duchêne, D., Fattal, F., Legendre, J.Y., Eds.; Editions de Santé: Paris, 2001; 386-389.
    • (2001) New Trends in Polymers for Oral and Parenteral Administration: From Design to Receptors , pp. 386-389
    • Garcia, M.1    Torres-Lugo, M.2    Alonso, M.J.3    Peppas, N.A.4
  • 14
    • 0037123696 scopus 로고    scopus 로고
    • Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers
    • Morishita, M.; Lowman, A.M.; Takayama, K.; Nagai, T.; Peppas, N.A. Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J. Control. Release 2002, 81, 25-32.
    • (2002) J. Control. Release , vol.81 , pp. 25-32
    • Morishita, M.1    Lowman, A.M.2    Takayama, K.3    Nagai, T.4    Peppas, N.A.5
  • 15
    • 0037161341 scopus 로고    scopus 로고
    • Preparation of stable insulin-loaded nanospheres of poly(ethylene glycol) macromers and N-isopropyl acrylamide
    • Leobandung, W.; Ichikawa, H.; Fukumori, Y.; Peppas, N.A. Preparation of stable insulin-loaded nanospheres of poly(ethylene glycol) macromers and N-isopropyl acrylamide. J. Control. Release 2002, 80, 357-363.
    • (2002) J. Control. Release , vol.80 , pp. 357-363
    • Leobandung, W.1    Ichikawa, H.2    Fukumori, Y.3    Peppas, N.A.4
  • 16
    • 0037161419 scopus 로고    scopus 로고
    • Preparation and characterization of pH-responsive poly(methacrylic acid-g-poly(ethylene glycol) nanospheres
    • Robinson, D.N.; Peppas, N.A. Preparation and characterization of pH-responsive poly(methacrylic acid-g-poly(ethylene glycol) nanospheres. Macromolecules 2002, 35, 3668-3674.
    • (2002) Macromolecules , vol.35 , pp. 3668-3674
    • Robinson, D.N.1    Peppas, N.A.2
  • 17
    • 0036377191 scopus 로고    scopus 로고
    • Preparation and characterization of P(MAA-g-EG) nanospheres for protein delivery applications
    • Torres-Lugo, M.; Peppas, N.A. Preparation and characterization of P(MAA-g-EG) nanospheres for protein delivery applications. J. Nanopart. Res. 2002, 4, 73-81.
    • (2002) J. Nanopart. Res. , vol.4 , pp. 73-81
    • Torres-Lugo, M.1    Peppas, N.A.2
  • 18
    • 0034000923 scopus 로고    scopus 로고
    • Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces
    • Huang, Y.; Leobandung, W.; Foss, A.; Peppas, N.A. Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces. J. Control. Release 2000, 65, 63-71.
    • (2000) J. Control. Release , vol.65 , pp. 63-71
    • Huang, Y.1    Leobandung, W.2    Foss, A.3    Peppas, N.A.4
  • 19
    • 0037022477 scopus 로고    scopus 로고
    • Direct measurement of interactions between tethered PEG chains and adsorbed mucin layers
    • Huang, Y.; Efremova, N.; Peppas, N.A.; Leckband, D.E. Direct measurement of interactions between tethered PEG chains and adsorbed mucin layers. Langmuir 2002, 18, 836-845.
    • (2002) Langmuir , vol.18 , pp. 836-845
    • Huang, Y.1    Efremova, N.2    Peppas, N.A.3    Leckband, D.E.4
  • 20
    • 0032782252 scopus 로고    scopus 로고
    • Complexation graft copolymers networks: Swelling properties calcium binding and proteolytic enzyme inhibition
    • Madsen, F.; Peppas, N.A. Complexation graft copolymers networks: swelling properties calcium binding and proteolytic enzyme inhibition. Biomaterials 1999, 20, 1701-1708.
    • (1999) Biomaterials , vol.20 , pp. 1701-1708
    • Madsen, F.1    Peppas, N.A.2
  • 21
    • 1842850708 scopus 로고    scopus 로고
    • Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures
    • Foss, A.; Peppas, N.A. Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures. Eur. J. Pharm. Biopharm. 2004, 57, 530-537.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 530-537
    • Foss, A.1    Peppas, N.A.2
  • 23
    • 0036902727 scopus 로고    scopus 로고
    • Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
    • Kim, B.; Peppas, N.A. Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems. J. Biomater. Sci., Polym. Ed. 2002, 13, 1271-1281.
    • (2002) J. Biomater. Sci., Polym. Ed. , vol.13 , pp. 1271-1281
    • Kim, B.1    Peppas, N.A.2
  • 24
    • 0037016085 scopus 로고    scopus 로고
    • Complexation phenomena in pH-responsive copolymer networks with pendent saccharides
    • Kim, B.; Peppas, N.A. Complexation phenomena in pH-responsive copolymer networks with pendent saccharides. Macromolecules 2002, 35, 9545-9550.
    • (2002) Macromolecules , vol.35 , pp. 9545-9550
    • Kim, B.1    Peppas, N.A.2
  • 26
    • 0000568906 scopus 로고
    • Preparation of buffer systems of constant ionic strength
    • Elving, P.J.; Markowitz, J.M.; Rosenthal, I. Preparation of buffer systems of constant ionic strength. Anal. Chem. 1956, 28, 1179-1180.
    • (1956) Anal. Chem. , vol.28 , pp. 1179-1180
    • Elving, P.J.1    Markowitz, J.M.2    Rosenthal, I.3
  • 27
    • 0042227216 scopus 로고    scopus 로고
    • Pulsatile drug delivery based on a complexation/decomplexation mechanism
    • Dinh, S.M., DeNuzzio, J.D., Comfort, A.R., Eds.; ACS Symposium Series: Washington, D.C., American Chemical Society (ACS)
    • Lowman, A.M.; Peppas, N.A. Pulsatile drug delivery based on a complexation/decomplexation mechanism. In Intelligent Materials for Controlled Release; Dinh, S.M., DeNuzzio, J.D., Comfort, A.R., Eds.; ACS Symposium Series: Washington, D.C., American Chemical Society (ACS), 1999; Vol. 728, 30-42.
    • (1999) Intelligent Materials for Controlled Release , vol.728 , pp. 30-42
    • Lowman, A.M.1    Peppas, N.A.2
  • 28
    • 0032595912 scopus 로고    scopus 로고
    • Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin
    • Torres-Lugo, M.; Peppas, N.A. Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 1999, 32, 6646-6651.
    • (1999) Macromolecules , vol.32 , pp. 6646-6651
    • Torres-Lugo, M.1    Peppas, N.A.2
  • 29
    • 0037035213 scopus 로고    scopus 로고
    • Monodisperse nanoparticles of poly(ethylene glycol) macromers and N-isopropyl acrylamide for biomedical applications
    • Leobandung, W.; Ichikawa, H.; Fukumori, Y.; Peppas, N.A. Monodisperse nanoparticles of poly(ethylene glycol) macromers and N-isopropyl acrylamide for biomedical applications. J. Appl. Polym. Sci. 2003, 87, 1678-1684.
    • (2003) J. Appl. Polym. Sci. , vol.87 , pp. 1678-1684
    • Leobandung, W.1    Ichikawa, H.2    Fukumori, Y.3    Peppas, N.A.4
  • 30
    • 0141941991 scopus 로고    scopus 로고
    • Insulin transport across cell monolayers in the presence of complexation hydrogels
    • Kavimandan, N.J.; Peppas, N.A. Insulin transport across cell monolayers in the presence of complexation hydrogels. Trans. Soc. Biomater. 2003, 29, 248.
    • (2003) Trans. Soc. Biomater. , vol.29 , pp. 248
    • Kavimandan, N.J.1    Peppas, N.A.2
  • 31
    • 0141872841 scopus 로고    scopus 로고
    • Use of complexation hydrogels for oral administration of chemotherapeutic agents
    • Blanchette, J.; Park, K.; Peppas, N.A. Use of complexation hydrogels for oral administration of chemotherapeutic agents. Trans. Soc. Biomater. 2003, 29, 246.
    • (2003) Trans. Soc. Biomater. , vol.29 , pp. 246
    • Blanchette, J.1    Park, K.2    Peppas, N.A.3
  • 32
    • 0038443086 scopus 로고    scopus 로고
    • Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery
    • Kim, B.; La Flamme, K.; Peppas, N.A. Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery. J. Appl. Polym. Sci. 2003, 89, 1606-1613.
    • (2003) J. Appl. Polym. Sci. , vol.89 , pp. 1606-1613
    • Kim, B.1    La Flamme, K.2    Peppas, N.A.3
  • 33
    • 0347811224 scopus 로고    scopus 로고
    • Experimental investigation of the effect of complexation hydrogels on insulin transport across model intestinal cell monolayers
    • Kavimandan, N.J.; Peppas, N.A.; Morishita, M.; Goto, T.; Nagai, T.; Takayama, K. Experimental investigation of the effect of complexation hydrogels on insulin transport across model intestinal cell monolayers. Drug Deliv. Syst. 2003, 18, 283.
    • (2003) Drug Deliv. Syst. , vol.18 , pp. 283
    • Kavimandan, N.J.1    Peppas, N.A.2    Morishita, M.3    Goto, T.4    Nagai, T.5    Takayama, K.6
  • 34
    • 3042618332 scopus 로고    scopus 로고
    • Development of oral insulin delivery systems and evaluation as pharmaceutical dosage forms in diabetic rats
    • Morishita, M.; Goto, T.; Nagai, T.; Peppas, N.A.; Takayama, K. Development of oral insulin delivery systems and evaluation as pharmaceutical dosage forms in diabetic rats. Drug Deliv. Syst. 2003, 18, 282.
    • (2003) Drug Deliv. Syst. , vol.18 , pp. 282
    • Morishita, M.1    Goto, T.2    Nagai, T.3    Peppas, N.A.4    Takayama, K.5
  • 35
    • 0038023097 scopus 로고    scopus 로고
    • Analysis of molecular interactions in P(MAA-g-EG) hydrogels
    • Kim, B.; Peppas, N.A. Analysis of molecular interactions in P(MAA-g-EG) hydrogels. Polymer 2003, 44, 3701-3707.
    • (2003) Polymer , vol.44 , pp. 3701-3707
    • Kim, B.1    Peppas, N.A.2
  • 36
    • 0346121668 scopus 로고    scopus 로고
    • PEG-containing hydrogel microparticles for oral protein delivery applications
    • Kim, B.; Peppas, N.A. PEG-containing hydrogel microparticles for oral protein delivery applications. Biomed. Microdevices 2003, 5, 333-341.
    • (2003) Biomed. Microdevices , vol.5 , pp. 333-341
    • Kim, B.1    Peppas, N.A.2
  • 37
    • 0141894188 scopus 로고    scopus 로고
    • In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers
    • Kim, B.; Peppas, N.A. In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers. Int. J. Pharm. 2003, 266, 29-37.
    • (2003) Int. J. Pharm. , vol.266 , pp. 29-37
    • Kim, B.1    Peppas, N.A.2
  • 38
    • 0348014780 scopus 로고    scopus 로고
    • Novel complexation hydrogels for oral peptide delivery: In vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers
    • Ichikawa, H.; Peppas, N.A. Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers. J. Biomed. Mater. Res. 2003, 67, 609-617.
    • (2003) J. Biomed. Mater. Res. , vol.67 , pp. 609-617
    • Ichikawa, H.1    Peppas, N.A.2
  • 39
    • 0346256860 scopus 로고    scopus 로고
    • Advances in biomaterials, drug delivery, and bionanotechnology
    • Langer, R.; Peppas, N.A. Advances in biomaterials, drug delivery, and bionanotechnology. AIChE J. 2003, 49, 2990-3006.
    • (2003) AIChE J. , vol.49 , pp. 2990-3006
    • Langer, R.1    Peppas, N.A.2
  • 40
    • 0346094228 scopus 로고    scopus 로고
    • Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications
    • Berger, J.; Reist, M.; Mayer, J.M.; Felt, O.; Peppas, N.A.; Gumy, R. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur. J. Pharm. Biopharm. 2004, 57, 19-34.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 19-34
    • Berger, J.1    Reist, M.2    Mayer, J.M.3    Felt, O.4    Peppas, N.A.5    Gumy, R.6
  • 41
    • 1342344092 scopus 로고    scopus 로고
    • Responsive and recognitive hydrogels using star polymers
    • Oral, E.; Peppas, N.A. Responsive and recognitive hydrogels using star polymers. J. Biomed. Mater. Res. 2004, 68A, 439-447.
    • (2004) J. Biomed. Mater. Res. , vol.68 A , pp. 439-447
    • Oral, E.1    Peppas, N.A.2
  • 42
    • 1842868900 scopus 로고    scopus 로고
    • Cellular evaluation of insulin transmucosal delivery
    • López, J.E.; Peppas, N.A. Cellular evaluation of insulin transmucosal delivery. J. Biomater. Sci., Polym. Ed. 2004, 15, 385-396.
    • (2004) J. Biomater. Sci., Polym. Ed. , vol.15 , pp. 385-396
    • López, J.E.1    Peppas, N.A.2
  • 44
    • 1542509571 scopus 로고    scopus 로고
    • Oral insulin delivery using P(MAA-g-EG) hydrogels: Effects of network morphology on insulin delivery characteristics
    • Nakamura, K.; Murray, R.J.; Joseph, J.I.; Peppas, N.A.; Morishita, M.; Lowman, A.M. Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics. J. Control. Release, 2004, 95, 589-599.
    • (2004) J. Control. Release , vol.95 , pp. 589-599
    • Nakamura, K.1    Murray, R.J.2    Joseph, J.I.3    Peppas, N.A.4    Morishita, M.5    Lowman, A.M.6
  • 45
    • 33745605315 scopus 로고    scopus 로고
    • Structural and dynamic response of neutral and intelligent networks in biomedical environments
    • Peppas, N.A., Sefton, M.V., Eds.; Academic Press: New York
    • Lowman, A.M.; Dziubla, T.D.; Bures, P.; Peppas, N.A. Structural and dynamic response of neutral and intelligent networks in biomedical environments. In Molecular and Cellular Foundations of Biomaterials; Peppas, N.A., Sefton, M.V., Eds.; Academic Press: New York, 2004; 75-130.
    • (2004) Molecular and Cellular Foundations of Biomaterials , pp. 75-130
    • Lowman, A.M.1    Dziubla, T.D.2    Bures, P.3    Peppas, N.A.4


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