Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy

Protein Engineering, Design and Selection

Volumn 27, Issue 6, 2014, Pages 179-190

  Kwok, Hang Fai ^a,b   Botkjaer, Kenneth A ^a,c   Tape, Christopher J ^a,d   Huang, Yanchao ^a   McCafferty, John ^a   Murphy, Gillian ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b University of Macau   (Macao)

^c AARHUS UNIVERSITY   (Denmark)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

anti TACE antibody; exosite; immunoreactivity; phage display randomization libraries; sub nanomolar affinity

Indexed keywords

ANTIBODIES; ASSAYS; BINDING ENERGY; CLONING; DISEASES; LIBRARIES; MAMMALS; PEPTIDES; RANDOM PROCESSES;

CHEMOTHERAPEUTIC AGENTS; COMPLEMENTARITY-DETERMINING REGION 3; EXOSITE; IMMUNOREACTIVITIES; PHAGE-DISPLAY; PHARMACOKINETIC PROPERTIES; SUB-NANOMOLAR AFFINITY; THERAPEUTIC APPLICATION;

ENZYME INHIBITION;

GEMCITABINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2; SCFV A9 ANTIBODY; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG; ADAM PROTEIN; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; PROTEIN BINDING; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; QUENCHED FLUORESCENT PEPTIDE ASSAY; SURFACE PLASMON RESONANCE; ALLOSTERISM; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; CHEMISTRY; DRUG SCREENING; HEK293 CELL LINE; IC50; IMMUNOLOGY; IMMUNOTHERAPY; KINETICS; METABOLISM; TUMOR CELL LINE;

ADAM PROTEINS; ALLOSTERIC REGULATION; ANIMALS; ANTIBODY SPECIFICITY; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DEOXYCYTIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HUMANS; IMMUNOTHERAPY; INHIBITORY CONCENTRATION 50; KINETICS; MICE; PROTEIN BINDING; SINGLE-CHAIN ANTIBODIES;

EID: 84901438662     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu010     Document Type: Article

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