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Volumn 10, Issue 1, 2014, Pages 3-9

DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)

Author keywords

Biomarkers; DNA methylation; Epigenetic mechanisms; Oncogenes; Ovarian cancer; Tumor suppressor genes

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST CANCER RESISTANCE PROTEIN; CADHERIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DEATH ASSOCIATED PROTEIN KINASE; H CADHERIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MISMATCH REPAIR PROTEIN PMS2; PLATINUM; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SECRETED FRIZZLED RELATED PROTEIN 5; TRANSCRIPTION FACTOR HOXA9; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG; UVOMORULIN; DNA (CYTOSINE 5) METHYLTRANSFERASE; ENZYME INHIBITOR;

EID: 84901436722     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2221     Document Type: Review
Times cited : (63)

References (97)
  • 3
    • 63049115790 scopus 로고    scopus 로고
    • Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: A Phase III Trial of the Gynecologic Cancer Intergroup
    • Bookman MA, Brady MF, McGuire WP, et al: Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup. J Clin Oncol 27: 1419-1425, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 1419-1425
    • Bookman, M.A.1    Brady, M.F.2    McGuire, W.P.3
  • 4
    • 0029955159 scopus 로고    scopus 로고
    • The genetic attributable risk of breast and ovarian cancer
    • DOI 10.1002/(SICI)1097-0142(19960601)77:11<2318::A
    • Claus EB, Schildkraut JM, Thompson WD and Risch NJ: The genetic attributable risk of breast and ovarian cancer. Cancer 77: 2318-2324, 1996. (Pubitemid 26162426)
    • (1996) Cancer , vol.77 , Issue.11 , pp. 2318-2324
    • Claus, E.B.1    Schildkraut, J.M.2    Thompson, W.D.3    Risch, N.J.4
  • 6
    • 84856746185 scopus 로고    scopus 로고
    • Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: A Gynecologic Oncology Group study
    • Tian C, Ambrosone CB, Darcy KM, Krivak TC, Armstrong DK, Bookman MA, Davis W, Zhao H, Moysich K, Gallion H and DeLoia JA: Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study. Gynecol Oncol 124: 575-581, 2012.
    • (2012) Gynecol Oncol , vol.124 , pp. 575-581
    • Tian, C.1    Ambrosone, C.B.2    Darcy, K.M.3    Krivak, T.C.4    Armstrong, D.K.5    Bookman, M.A.6    Davis, W.7    Zhao, H.8    Moysich, K.9    Gallion, H.10    DeLoia, J.A.11
  • 7
    • 67651225134 scopus 로고    scopus 로고
    • Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: A Gynecologic Oncology Group study
    • Darcy KM, Brady WE, Blancato JK, Dickson RB, Hoskins WJ, McGuire WP and Birrer MJ: Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: a Gynecologic Oncology Group study. Gynecol Oncol 114: 472-479, 2009.
    • (2009) Gynecol Oncol , vol.114 , pp. 472-479
    • Darcy, K.M.1    Brady, W.E.2    Blancato, J.K.3    Dickson, R.B.4    Hoskins, W.J.5    McGuire, W.P.6    Birrer, M.J.7
  • 9
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction?
    • DOI 10.1038/nrc1799, PII N1799
    • Baylin SB and Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6: 107-116, 2006. (Pubitemid 43361543)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.2 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 10
    • 75649094543 scopus 로고    scopus 로고
    • Aberrant DNA methylation in contrast with mutations
    • Ushijima T and Asada K: Aberrant DNA methylation in contrast with mutations. Cancer Sci 101: 300-305, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 300-305
    • Ushijima, T.1    Asada, K.2
  • 11
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo CB and Jones PA: Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5: 37-50, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 13
    • 33847065486 scopus 로고    scopus 로고
    • The Epigenomics of Cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • Jones PA and Baylin SB: The epigenomics of cancer. Cell 128: 683-692, 2007. (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 14
    • 84860652628 scopus 로고    scopus 로고
    • Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
    • Wilting RH and Dannenberg JH: Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance. Drug Resist Updat 15: 21-38, 2012.
    • (2012) Drug Resist Updat , vol.15 , pp. 21-38
    • Wilting, R.H.1    Dannenberg, J.H.2
  • 15
    • 84858251272 scopus 로고    scopus 로고
    • DNA methylation in the human placenta and fetal growth
    • Review
    • Koukoura O, Sifakis S and Spandidos DA: DNA methylation in the human placenta and fetal growth (Review). Mol Med Rep 5: 883-839, 2012.
    • (2012) Mol Med Rep , vol.5 , pp. 883-1839
    • Koukoura, O.1    Sifakis, S.2    Spandidos, D.A.3
  • 16
    • 0345357773 scopus 로고    scopus 로고
    • Gene Silencing in Cancer in Association with Promoter Hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman JG and Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054, 2003. (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 17
    • 34250188803 scopus 로고    scopus 로고
    • Genomic patterns of DNA methylation: Targets and function of an epigenetic mark
    • DOI 10.1016/j.ceb.2007.04.011, PII S0955067407000634, Nucleus and Gene Expression
    • Weber M and Schubeler D: Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr Opin Cell Biol 19: 273-280, 2007. (Pubitemid 46899512)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.3 , pp. 273-280
    • Weber, M.1    Schubeler, D.2
  • 18
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression-belts, braces, and chromatin
    • Bird AP and Wolffe AP: Methylation-induced repression - belts, braces, and chromatin. Cell 99: 451-454, 1999. (Pubitemid 129746827)
    • (1999) Cell , vol.99 , Issue.5 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 20
    • 0033580432 scopus 로고    scopus 로고
    • Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: Correlation with disease characteristics
    • Catteau A, Harris WH, Xu CF and Solomon E: Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics. Oncogene 18: 1957-1965, 1999. (Pubitemid 29150082)
    • (1999) Oncogene , vol.18 , Issue.11 , pp. 1957-1965
    • Catteau, A.1    Harris, W.H.2    Xu, C.-F.3    Solomon, E.4
  • 21
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M: Epigenetics in cancer. N Engl J Med 358: 1148-1159, 2008.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 23
    • 33746468951 scopus 로고    scopus 로고
    • Aberrant gene silencing in tumor progression: Implications for control of cancer
    • DOI 10.1101/sqb.2005.70.010
    • Baylin SB and Chen WY: Aberrant gene silencing in tumor progression: implications for control of cancer. Cold Spring Harb Symp Quant Biol 70: 427-433, 2005. (Pubitemid 44124898)
    • (2005) Cold Spring Harbor Symposia on Quantitative Biology , vol.70 , pp. 427-433
    • Baylin, S.B.1    Chen, W.Y.2
  • 27
    • 0034307160 scopus 로고    scopus 로고
    • BRCA1 promoter region hypermethylation in ovarian carcinoma: A population-based study
    • Baldwin RL, Nemeth E, Tran H, et al: BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 60: 5329-5333, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5329-5333
    • Baldwin, R.L.1    Nemeth, E.2    Tran, H.3
  • 29
    • 84866608818 scopus 로고    scopus 로고
    • Links between genome integrity and BRCA1 tumor suppression
    • Li ML and Greenberg RA: Links between genome integrity and BRCA1 tumor suppression. Trends Biochem Sci 37: 418-424, 2012.
    • (2012) Trends Biochem Sci , vol.37 , pp. 418-424
    • Li, M.L.1    Greenberg, R.A.2
  • 30
    • 4344665689 scopus 로고    scopus 로고
    • The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer
    • McCoy ML, Mueller CR and Roskelley CD: The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer. Reprod Biol Endocrinol 1: 72, 2003.
    • (2003) Reprod Biol Endocrinol , vol.1 , pp. 72
    • McCoy, M.L.1    Mueller, C.R.2    Roskelley, C.D.3
  • 31
    • 84860251742 scopus 로고    scopus 로고
    • High frequency of allelic loss at the BRCA1 locus in ovarian cancers: Clinicopathologic and molecular associations
    • Rzepecka IK, Szafron L, Stys A, et al: High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations. Cancer Genet 205: 94-100, 2012.
    • (2012) Cancer Genet , vol.205 , pp. 94-100
    • Rzepecka, I.K.1    Szafron, L.2    Stys, A.3
  • 33
    • 0037099625 scopus 로고    scopus 로고
    • Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer
    • Chan KY, Ozcelik H, Cheung AN, Ngan HY and Khoo US: Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Res 62: 4151-4156, 2002. (Pubitemid 34791087)
    • (2002) Cancer Research , vol.62 , Issue.14 , pp. 4151-4156
    • Chan, K.Y.K.1    Ozcelik, H.2    Cheung, A.N.Y.3    Ngan, H.Y.S.4    Khoo, U.-S.5
  • 34
    • 84875247647 scopus 로고    scopus 로고
    • Epigenetic inactivation of BRCA1 through promoter hypermethylation in ovarian cancer progression
    • Wang YQ, Yan Q, Zhang JR, Li SD, Yang YX and Wan XP: Epigenetic inactivation of BRCA1 through promoter hypermethylation in ovarian cancer progression. J Obstet Gynaecol Res 39: 549-554, 2013.
    • (2013) J Obstet Gynaecol Res , vol.39 , pp. 549-554
    • Wang, Y.Q.1    Yan, Q.2    Zhang, J.R.3    Li, S.D.4    Yang, Y.X.5    Wan, X.P.6
  • 35
    • 1142311552 scopus 로고    scopus 로고
    • Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene
    • DOI 10.1002/path.1507
    • Wang C, Horiuchi A, Imai T, et al: Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene. J Pathol 202: 215-223, 2004. (Pubitemid 38208659)
    • (2004) Journal of Pathology , vol.202 , Issue.2 , pp. 215-223
    • Wang, C.1    Horiuchi, A.2    Imai, T.3    Ohira, S.4    Itoh, K.5    Nikaido, T.6    Katsuyama, Y.7    Konishi, I.8
  • 36
    • 33748639077 scopus 로고    scopus 로고
    • Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data
    • Yang HJ, Liu VW, Wang Y, Tsang PC and Ngan HY: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer 6: 212, 2006.
    • (2006) BMC Cancer , vol.6 , pp. 212
    • Yang, H.J.1    Liu, V.W.2    Wang, Y.3    Tsang, P.C.4    Ngan, H.Y.5
  • 39
    • 67649452451 scopus 로고    scopus 로고
    • Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers
    • Kontorovich T, Cohen Y, Nir U and Friedman E: Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. Breast Cancer Res Treat 116: 195-200, 2009.
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 195-200
    • Kontorovich, T.1    Cohen, Y.2    Nir, U.3    Friedman, E.4
  • 42
    • 22244492665 scopus 로고    scopus 로고
    • DNA mismatch repair
    • DOI 10.1146/annurev.biochem.74.082803.133243
    • Kunkel TA and Erie DA: DNA mismatch repair. Annu Rev Biochem 74: 681-710, 2005. (Pubitemid 40995521)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 681-710
    • Kunkel, T.A.1    Erie, D.A.2
  • 43
    • 80052035210 scopus 로고    scopus 로고
    • Frequency of mismatch repair deficiency in ovarian cancer: A systematic review. This article is a US Government work and, as such, is in the public domain of the United States of America
    • Murphy MA and Wentzensen N: Frequency of mismatch repair deficiency in ovarian cancer: a systematic review. This article is a US Government work and, as such, is in the public domain of the United States of America. Int J Cancer 129: 1914-1922, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 1914-1922
    • Murphy, M.A.1    Wentzensen, N.2
  • 44
    • 54349126239 scopus 로고    scopus 로고
    • Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer
    • Zhang H, Zhang S, Cui J, Zhang A, Shen L and Yu H: Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol 48: 505-509, 2008.
    • (2008) Aust N Z J Obstet Gynaecol , vol.48 , pp. 505-509
    • Zhang, H.1    Zhang, S.2    Cui, J.3    Zhang, A.4    Shen, L.5    Yu, H.6
  • 45
    • 34249294535 scopus 로고    scopus 로고
    • A change in promoter methylation of hMLH1 is a cause of acquired resistance to platinum-based chemotherapy in epithelial ovarian cancer
    • Watanabe Y, Ueda H, Etoh T, et al: A change in promoter methylation of hMLH1 is a cause of acquired resistance to platinum-based chemotherapy in epithelial ovarian cancer. Anticancer Res 27: 1449-1452, 2007. (Pubitemid 46807221)
    • (2007) Anticancer Research , vol.27 , Issue.3 B , pp. 1449-1452
    • Watanabe, Y.1    Ueda, H.2    Etoh, T.3    Koike, E.4    Fujinami, N.5    Mitsuhashi, A.6    Hoshiai, H.7
  • 46
    • 40949087119 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment
    • Barton CA, Hacker NF, Clark SJ and O'Brien PM: DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol Oncol 109: 129-139, 2008.
    • (2008) Gynecol Oncol , vol.109 , pp. 129-139
    • Barton, C.A.1    Hacker, N.F.2    Clark, S.J.3    O'Brien, P.M.4
  • 49
    • 1642334155 scopus 로고    scopus 로고
    • Promoter hypermethylation of MGMT, CDHI, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin
    • DOI 10.1038/sj.bjc.6601567
    • Dhillon VS, Young AR, Husain SA and Aslam M: Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin. Br J Cancer 90: 874-881, 2004. (Pubitemid 38406600)
    • (2004) British Journal of Cancer , vol.90 , Issue.4 , pp. 874-881
    • Dhillon, V.S.1    Young, A.R.2    Husain, S.A.3    Aslam, M.4
  • 51
    • 27544511900 scopus 로고    scopus 로고
    • Homeobox gene expression in cancer: Insights from developmental regulation and deregulation
    • DOI 10.1016/j.ejca.2005.08.014, PII S0959804905007136, Transcription Factors in Cancer
    • Samuel S and Naora H: Homeobox gene expression in cancer: insights from developmental regulation and deregulation. Eur J Cancer 41: 2428-2437, 2005. (Pubitemid 41540620)
    • (2005) European Journal of Cancer , vol.41 , Issue.16 , pp. 2428-2437
    • Samuel, S.1    Naora, H.2
  • 53
    • 84856711573 scopus 로고    scopus 로고
    • Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer
    • Montavon C, Gloss BS, Warton K, et al: Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer. Gynecol Oncol 124: 582-588, 2012.
    • (2012) Gynecol Oncol , vol.124 , pp. 582-588
    • Montavon, C.1    Gloss, B.S.2    Warton, K.3
  • 54
    • 70249116811 scopus 로고    scopus 로고
    • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study
    • Widschwendter M, Apostolidou S, Jones AA, et al: HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. Int J Cancer 125: 2214-2218, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 2214-2218
    • Widschwendter, M.1    Apostolidou, S.2    Jones, A.A.3
  • 55
    • 70350048828 scopus 로고    scopus 로고
    • Methylation and protein expression of DNA repair genes: Association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas
    • Swisher EM, Gonzalez RM, Taniguchi T, et al: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. Mol Cancer 8: 48, 2009.
    • (2009) Mol Cancer , vol.8 , pp. 48
    • Swisher, E.M.1    Gonzalez, R.M.2    Taniguchi, T.3
  • 61
    • 33746378353 scopus 로고    scopus 로고
    • Crucial roles of Sp1 and epigenetic modifications in the regulation of the cldn4 promoter in ovarian cancer cells
    • DOI 10.1074/jbc.M603767200
    • Honda H, Pazin MJ, Ji H, Wernyj RP and Morin PJ: Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J Biol Chem 281: 21433-21444, 2006. (Pubitemid 44115482)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.30 , pp. 21433-21444
    • Honda, H.1    Pazin, M.J.2    Ji, H.3    Wernyj, R.P.4    Morin, P.J.5
  • 62
    • 74949130404 scopus 로고    scopus 로고
    • Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer
    • Lee PS, Teaberry VS, Bland AE, et al: Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. Int J Cancer 126: 1378-1389, 2010.
    • (2010) Int J Cancer , vol.126 , pp. 1378-1389
    • Lee, P.S.1    Teaberry, V.S.2    Bland, A.E.3
  • 64
    • 48149100125 scopus 로고    scopus 로고
    • Epigenetic modification is involved in aberrant expression of class III β-tubulin, TUBB3, in ovarian cancer cells
    • Izutsu N, Maesawa C, Shibazaki M, et al: Epigenetic modification is involved in aberrant expression of class III β-tubulin, TUBB3, in ovarian cancer cells. Int J Oncol 32: 1227-1235, 2008.
    • (2008) Int J Oncol , vol.32 , pp. 1227-1235
    • Izutsu, N.1    Maesawa, C.2    Shibazaki, M.3
  • 65
    • 77954125830 scopus 로고    scopus 로고
    • Role of epigenomics in ovarian and endometrial cancers
    • Balch C, Matei DE, Huang TH and Nephew KP: Role of epigenomics in ovarian and endometrial cancers. Epigenomics 2: 419-447, 2010.
    • (2010) Epigenomics , vol.2 , pp. 419-447
    • Balch, C.1    Matei, D.E.2    Huang, T.H.3    Nephew, K.P.4
  • 66
    • 2442443111 scopus 로고    scopus 로고
    • Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene
    • DOI 10.1093/carcin/bgh066
    • Strathdee G, Davies BR, Vass JK, Siddiqui N and Brown R: Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene. Carcinogenesis 25: 693-701, 2004. (Pubitemid 38618520)
    • (2004) Carcinogenesis , vol.25 , Issue.5 , pp. 693-701
    • Strathdee, G.1    Davies, B.R.2    Vass, J.K.3    Siddiqui, N.4    Brown, R.5
  • 67
    • 20444461499 scopus 로고    scopus 로고
    • Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy
    • DOI 10.1016/j.ygyno.2005.03.023, PII S0090825805001915
    • Strathdee G, Vass JK, Oien KA, Siddiqui N, Curto-Garcia J and Brown R: Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy. Gynecol Oncol 97: 898-903, 2005. (Pubitemid 40824663)
    • (2005) Gynecologic Oncology , vol.97 , Issue.3 , pp. 898-903
    • Strathdee, G.1    Vass, J.K.2    Oien, K.A.3    Siddiqui, N.4    Curto-Garcia, J.5    Brown, R.6
  • 68
    • 0037310198 scopus 로고    scopus 로고
    • Hypomethylation of the Synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
    • Gupta A, Godwin AK, Vanderveer L, Lu A and Liu J: Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res 63: 664-673, 2003. (Pubitemid 36158146)
    • (2003) Cancer Research , vol.63 , Issue.3 , pp. 664-673
    • Gupta, A.1    Godwin, A.K.2    Vanderveer, L.3    Lu, A.4    Liu, J.5
  • 69
    • 77949533111 scopus 로고    scopus 로고
    • An epigenetic signature in peripheral blood predicts active ovarian cancer
    • Teschendorff AE, Menon U, Gentry-Maharaj A, et al: An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One 4: e8274, 2009.
    • (2009) PLoS One , vol.4
    • Teschendorff, A.E.1    Menon, U.2    Gentry-Maharaj, A.3
  • 70
    • 33646725688 scopus 로고    scopus 로고
    • Prognostic DNA methylation biomarkers in ovarian cancer
    • Wei SH, Balch C, Paik HH, et al: Prognostic DNA methylation biomarkers in ovarian cancer. Clin Cancer Res 12: 2788-2794, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 2788-2794
    • Wei, S.H.1    Balch, C.2    Paik, H.H.3
  • 72
    • 84879095890 scopus 로고    scopus 로고
    • A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA
    • Zhang Q, Hu G, Yang Q, et al: A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA. Gynecol Oncol 130: 132-139, 2013.
    • (2013) Gynecol Oncol , vol.130 , pp. 132-139
    • Zhang, Q.1    Hu, G.2    Yang, Q.3
  • 73
    • 0033945304 scopus 로고    scopus 로고
    • Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells
    • DOI 10.1046/j.1365-2958.2000.01976.x
    • Melnikov A, Zaborina O, Dhiman N, Prabhakar BS, Chakrabarty AM and Hendrickson W: Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells. Mol Microbiol 36: 1481-1493, 2000. (Pubitemid 30449982)
    • (2000) Molecular Microbiology , vol.36 , Issue.6 , pp. 1481-1493
    • Melnikov, A.1    Zaborina, O.2    Dhiman, N.3    Prabhakar, B.S.4    Chakrabarty, A.M.5    Hendrickson, W.6
  • 74
    • 33646560022 scopus 로고    scopus 로고
    • Systemic therapy for ovarian cancer: Current status and new treatments
    • Ozols RF: Systemic therapy for ovarian cancer: current status and new treatments. Semin Oncol 33: S3-S11, 2006.
    • (2006) Semin Oncol , vol.33
    • Ozols, R.F.1
  • 75
  • 76
    • 77954445464 scopus 로고    scopus 로고
    • Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway
    • Su HY, Lai HC, Lin YW, et al: Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 127: 555-567, 2010.
    • (2010) Int J Cancer , vol.127 , pp. 555-567
    • Su, H.Y.1    Lai, H.C.2    Lin, Y.W.3
  • 77
    • 68249136697 scopus 로고    scopus 로고
    • Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer
    • Nicholson LJ, Smith PR, Hiller L, et al: Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer. Int J Cancer 125: 1454-1463, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 1454-1463
    • Nicholson, L.J.1    Smith, P.R.2    Hiller, L.3
  • 78
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee G, MacKean MJ, Illand M and Brown R: A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 18: 2335-2341, 1999. (Pubitemid 29192710)
    • (1999) Oncogene , vol.18 , Issue.14 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 79
    • 61449106828 scopus 로고    scopus 로고
    • Epigenetic modifications of the estrogen receptor beta gene in epithelial ovarian cancer cells
    • Yap OW, Bhat G, Liu L and Tollefsbol TO: Epigenetic modifications of the estrogen receptor beta gene in epithelial ovarian cancer cells. Anticancer Res 29: 139-144, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 139-144
    • Yap, O.W.1    Bhat, G.2    Liu, L.3    Tollefsbol, T.O.4
  • 80
    • 0037112447 scopus 로고    scopus 로고
    • Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype
    • Lehmann U, Celikkaya G, Hasemeier B, Langer F and Kreipe H: Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype. Cancer Res 62: 6634-6638, 2002. (Pubitemid 35364131)
    • (2002) Cancer Research , vol.62 , Issue.22 , pp. 6634-6638
    • Lehmann, U.1    Celikkaya, G.2    Hasemeier, B.3    Langer, F.4    Kreipe, H.5
  • 81
    • 73349125059 scopus 로고    scopus 로고
    • CD133 expression defines a tumor initiating cell population in primary human ovarian cancer
    • Curley MD, Therrien VA, Cummings CL, et al: CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells 27: 2875-2883, 2009.
    • (2009) Stem Cells , vol.27 , pp. 2875-2883
    • Curley, M.D.1    Therrien, V.A.2    Cummings, C.L.3
  • 82
    • 68249159896 scopus 로고    scopus 로고
    • Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer
    • Li M, Balch C, Montgomery JS, et al: Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics 2: 34, 2009.
    • (2009) BMC Med Genomics , vol.2 , pp. 34
    • Li, M.1    Balch, C.2    Montgomery, J.S.3
  • 83
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird PW: The power and the promise of DNA methylation markers. Nat Rev Cancer 3: 253-266, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 84
    • 84869500199 scopus 로고    scopus 로고
    • Epigenomics and interindividual differences in drug response
    • Ivanov M, Kacevska M and Ingelman-Sundberg M: Epigenomics and interindividual differences in drug response. Clin Pharmacol Ther 92: 727-736, 2012.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 727-736
    • Ivanov, M.1    Kacevska, M.2    Ingelman-Sundberg, M.3
  • 89
    • 0037613315 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers
    • DOI 10.1016/S0303-7207(03)00084-4
    • Sasaki M, Kaneuchi M, Fujimoto S, Tanaka Y and Dahiya R: Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers. Mol Cell Endocrinol 202: 201-207, 2003. (Pubitemid 36593413)
    • (2003) Molecular and Cellular Endocrinology , vol.202 , Issue.1-2 , pp. 201-207
    • Sasaki, M.1    Kaneuchi, M.2    Fujimoto, S.3    Tanaka, Y.4    Dahiya, R.5
  • 91
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB and Brown R: Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 60: 6039-6044, 2000.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 92
    • 79952266135 scopus 로고    scopus 로고
    • Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer
    • Fu S, Hu W, Iyer R, et al: Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer. Cancer 117: 1661-1669, 2011.
    • (2011) Cancer , vol.117 , pp. 1661-1669
    • Fu, S.1    Hu, W.2    Iyer, R.3
  • 93
    • 77954121574 scopus 로고    scopus 로고
    • A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer
    • Fang F, Balch C, Schilder J, et al: A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer 116: 4043-4053, 2010.
    • (2010) Cancer , vol.116 , pp. 4043-4053
    • Fang, F.1    Balch, C.2    Schilder, J.3
  • 94
    • 84863091718 scopus 로고    scopus 로고
    • Epigenomics of ovarian cancer and its chemoprevention
    • Chen H, Hardy TM and Tollefsbol TO: Epigenomics of ovarian cancer and its chemoprevention. Front Genet 2: 67, 2011.
    • (2011) Front Genet , vol.2 , pp. 67
    • Chen, H.1    Hardy, T.M.2    Tollefsbol, T.O.3
  • 96
    • 0037728813 scopus 로고    scopus 로고
    • Triple analysis of the cancer epigenome: An integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation
    • Shi H, Wei SH, Leu YW, et al: Triple analysis of the cancer epigenome: an integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation. Cancer Res 63: 2164-2171, 2003. (Pubitemid 36538622)
    • (2003) Cancer Research , vol.63 , Issue.9 , pp. 2164-2171
    • Shi, H.1    Wei, S.H.2    Leu, Y.-W.3    Rahmatpanah, F.4    Liu, J.C.5    Yan, P.S.6    Nephew, K.P.7    Huang, T.H.-M.8


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