Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy

Gynecologic Oncology

Volumn 97, Issue 3, 2005, Pages 898-903

  Strathdee, Gordon ^a   Vass, J Keith ^b   Oien, Karin A ^a   Siddiqui, Nadeem ^c   Curto Garcia, Jorge ^a   Brown, Robert ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c STOBHILL HOSPITAL   (United Kingdom)

Author keywords

CpG island; DNA methylation; Drug resistance; MCJ; Ovarian cancer

Indexed keywords

BISULFITE; CARBOPLATIN; CISPLATIN; DEOXYRIBONUCLEOPROTEIN; DNA; METHYLATION CONTROLLED DNA J PROTEIN; TAXOID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TREATMENT OUTCOME;

BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; FEMALE; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM STAGING; OVARIAN NEOPLASMS; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA; SURVIVAL RATE;

EID: 20444461499     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygyno.2005.03.023     Document Type: Article

References (10)

1. R. Brown, and G. Strathdee Epigenomics and epigenetic therapy of cancer Trends Mol. Med. 8 Suppl 4 2002 S43 S48
2. A. Bird The relationship of DNA methylation to cancer Cancer Surv. 28 1996 87 110
3. J.F. Costello, and C. Plass Methylation matters J. Med. Genet. 38 2001 285 303
4. A. Bird, and A.P. Wolffe Methylation-induced repression-Belts, braces and chromatin Cell 99 1999 451 454
5. V. Shridhar, K.C. Bible, J. Staub, R. Avula, Y.K. Lee, and K. Kalli Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer Cancer Res. 61 2001 4258 4265
6. P. Harper Current clinical practices for ovarian cancers Semin. Oncol. 29 3 Suppl 8 2002 3 6
7. G. Strathdee, B.R. Davies, J.K. Vass, N. Siddiqui, and R. Brown Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene Carcinogenesis 25 5 2004 693 701
8. G. Strathdee, M. MacKean, M. Illand, and R. Brown A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer Oncogene 18 1999 2335 2341
9. M. Ehrlich DNA methylation in cancer: too much, but also too little Oncogene 21 35 2002 5400 5413
10. S.H. Wei, C.M. Chen, G. Strathdee, J. Harnsomburana, C.R. Shyu, and F. Rahmatpanah Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers Clin. Cancer Res. 8 7 2002 2246 2252