Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6634-6638

  Lehmann, Ulrich ^a   Celikkaya, Gülhan ^a   Hasemeier, Britta ^a   Länger, Florian ^a   Kreipe, Hans ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CYCLIN D1; DEATH ASSOCIATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INVASION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH ASSOCIATED PROTEIN KINASE GENE; DNA METHYLATION; ENZYME INACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TUMOR GROWTH;

APOPTOSIS REGULATORY PROTEINS; BREAST; BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, LOBULAR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENE SILENCING; HUMANS; HYPERPLASIA; LYMPH NODES; LYMPHOCYTES; NEOPLASM INVASIVENESS; REPRODUCIBILITY OF RESULTS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0037112447     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wajed, S. A., Laird, P. W., and DeMeester, T. R. DNA methylation: An alternative pathway to cancer. Ann. Surg., 234: 10-20, 2001.
2. Yang, X., Yan, L., and Davidson, N. E. DNA methylation in breast cancer. Endocr. Relat. Cancer, 8: 115-127, 2001.
3. Umbricht, C. B., Evron, E., Gabrielson, E., Ferguson, A., Marks, J., and Sukumar, S. Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. Oncogene, 20: 3348-3353, 2001.
4. Lehmann, U., Langer, F., Feist, H., Glockner, S., Hasemeier, B., and Kreipe, H. Quantitative assessment of promoter hypermethylation during breast cancer development. Am. J. Pathol., 160: 605-612, 2002.
5. Kissil, J. L., and Kimchi, A. Death-associated proteins: From gene identification to the analysis of their apoptotic and tumour suppressive functions. Mol. Med. Today, 4: 268-274, 1998.
6. Inbal, B., Cohen, O., Polak-Charcon, S., Kopolovic, J., Vadai, E., Eisenbach, L., and Kimchi, A. DAP kinase links the control of apoptosis to metastasis. Nature (Lond.), 390: 180-184, 1997.
7. Kang, G. H., Shim, Y. H., Jung, H. Y., Kim, W. H., Ro, J. Y., and Rhyu, M. G. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res., 61: 2847-2851, 2001.
8. Wong, T. S., Chang, H. W., Tang, K. C., Wei, W. I., Kwong, D. L., Sham, J. S., Yuen, A. P., and Kwong, Y. L. High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients. Clin. Cancer Res., 8: 433-437, 2002.
9. Lehmann, U., Glockner, S., Kleeberger, W., von Wasielewski, H. F., and Kreipe, H. Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction. Am. J. Pathol., 156: 1855-1864, 2000.
10. Lehmann, U., Hasemeier, B., Lilischkis. R., and Kreipe, H. Quantitative analysis of promoter hypermethylation in laser-microdissected archival specimens. Lab. Investig., 81: 635-638, 2001.
11. Lehmann, U., Bock, O., Langer, F., and Kreipe, H. Demonstration of light chain restricted clonal B-lymphoid infiltrates in archival bone marrow trephines by quantitative real-time polymerase chain reaction. Am. J. Pathol., 159: 2023-2029, 2001.
12. von Wasielewski, R., Mengel, M., Gignac, S., Wilkens, L., Wemer, M., and Georgii, A. Tyramine amplification technique in routine immunohistochemistry. J. Histochem. Cytochem., 45: 1455-1459, 1997.
13. Cameron, E. E., Baylin, S. B., and Herman, J. G. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood, 94: 2445-2451. 1999.
14. Robertson, K. D. DNA methylation, methyltransferases, and cancer. Oncogene, 20: 3139-3155, 2001.
15. Issa. J. P. CpG-island methylation in aging and cancer. Curr. Top. Microbiol. Immunol., 249: 101-118, 2000.
16. Droufakou, S., Deshmane, V., Roylance, R., Hanby, A., Tomlinson, L, and Hart, I. R. Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast. Int. J. Cancer, 92: 404-408, 2001.
17. Graff, J. R., Herman, J. G., Lapidus, R. G., Chopra, H., Xu, R., Jarrard, D, F., Isaacs, W. B., Pitha, P. M., Davidson, N. E., and Baylin, S. B. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res., 55: 5195-5199, 1995.
18. Kim, D. H., Nelson, H. H., Wiencke, J. K., Zheng, S., Christiani, D. C., Wain. J. C., Mark, E. J., and Kelsey, K. T. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res., 61: 3419-3424, 2001.
19. Osada, H., Tatematsu. Y., Yatabe, Y., Nakagawa, T., Konishi, H., Harano, T., Tezel, E., Takada, M., and Takahashi, T. Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers. Oncogene. 21: 2418-2424, 2002.
20. Graff, J. R., Greenberg, V. E., Herman, J. G., Westra, W. H., Boghaert, E. R., Ain, K. B., Saji, M., Zeiger, M. A., Zimmer. S. G., and Baylin, S. B. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular. Hurthle's cell, and poorly differentiated human thyroid carcinoma, Cancer Res., 58: 2063-2066, 1998.
21. Simpson, D. J., Clayton, R. N., and Farrell, W. E. Preferential loss of Death Associated Protein kinase expression in invasive pituitary turnouts is associated with either CpG island methylation or homozygous deletion. Oncogene. 21: 1217-1224. 2002.
22. Raveh, T., Droguett, G., Horwitz, M. S., DePinho. R. A., and Kimchi, A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat. Cell Biol., 3: 1-7.