Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes i and II and the transmembrane tumor-associated isozymes IX and XII

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 47-55

  Sławiński, Jarosław ^a   Pogorzelska, Aneta ^a   Zołnowska, Beata ^a   Brozewicz, Kamil ^a   Vullo, Daniela ^b   Supuran, Claudiu T ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

2,4 Dichlorobenzenesulfonamides; Carbonic anhydrase isozymes I, II, IX and XII inhibitors; Synthesis

Indexed keywords

2,4 DICHLORO 5 (2 BENZOYLHYDRAZINECARBONYL)BENZENESULFONAMIDE; 2,4 DICHLORO 5 (3 PHENYLUREIDO)BENZENESULFONAMIDE; 2,4 DICHLORO 5 (5 PHENYL 1,2,4 TRIAZOL 3 YL)BENZENESULFONAMIDE; 2,4 DICHLORO 5 (5 PHENYL 1,3,4 OXADIAZOL 2 YL)BENZENESULFONAMIDE; 2,4 DICHLORO 5 (5 PHENYL 1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 2,4 DICHLORO 5 ISOCYANATOBENZENESULFONAMIDE; 2,4 DICHLORO 5 SULFAMOYLBENZOYL AZIDE; 2,4 DICHLORO 5 [2 (4 CHLOROBENZOYL)HYDRAZINECARBONYL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [2 (4 METHYLBENZOYL)HYDRAZINECARBONYL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [2 (FURAN 2 CARBONYL)HYDRAZINECARBONYL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [3 (3 MORPHOLINOPROPYL)UREIDO]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [3 (4 CHLOROPHENYL)UREIDO]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [3 (4 SULFAMOYLPHENYL)UREIDO]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [5 (4 CHLOROPHENYL) 1,2,4 TRIAZOL 3 YL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [5 (4 CHLOROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [5 (4 METHYLPHENYL) 1,3,4 OXADIAZOL 2 YL]BENZENESULFONAMIDE; 2,4 DICHLORO 5 [5 (PHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]BENZENESULFONAMIDE; 4 (BENZODIOXOL 5 YLMETHYL)N(2,4 DICHLORO 5 SULFAMOYLPHENYL)PIPERAZINE 1 CARBOXAMIDE; 5 (3 BENZYLUREIDO) 2,4 DICHLOROBENZENESULFONAMIDE; 5 [2 (BENZOYLHYDRAZINECARBONYL) 2,4 DICHLOROBENZENESULFONAMIDE; 5 [3 (1H INDOL 1 YL)UREIDO] 2,4 DICHLOROBENZENESULFONAMIDE; 5 [3 (BENZYLOXY)UREIDO] 2,4 DICHLOROBENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; N(2,4 DICHLORO 5 SULFAMOYLBENZOYL)N''(4 CHLOROPHENYL)THIOSEMICARBAZIDE; N(2,4 DICHLORO 5 SULFAMOYLBENZOYL)N''(PHENYL)THIOSEMICARBAZIDE; UNCLASSIFIED DRUG; CARBONATE DEHYDRATASE; ISOENZYME; SULFONAMIDE;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; METABOLISM; NEOPLASM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84901422514     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.039     Document Type: Article

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