The social brain meets the reactive genome: Neuroscience, epigenetics and the new social biology

Frontiers in Human Neuroscience

Volumn 8, Issue MAY, 2014, Pages

  Meloni, Maurizio ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Epigenetics; Meaney; Methylation; Neuroepigenetics; Plasticity; Postgenomics; Social neuroscience

Indexed keywords

UNTRANSLATED RNA;

ARTICLE; BRAIN FUNCTION; CHROMATIN STRUCTURE; DNA METHYLATION; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; EPIGENETICS; EPISTEMOLOGY; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; HEREDITY; HERITABILITY; HISTONE MODIFICATION; HUMAN; MATERNAL CARE; MENTAL DISEASE; NERVE CELL PLASTICITY; NONHUMAN; PSYCHOTRAUMA; SOCIAL BEHAVIOR; SOCIAL INTERACTION; STIGMA;

EID: 84901422492     PISSN: None     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2014.00309     Document Type: Article

References (177)

1. Anway, M. D., Cupp, A. S., Uzumcu, M., and Skinner, M. K. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308, 1466-1469. doi: 10.1126/science.1108190
2. Badyaev, A. V., and Uller, T. (2009). Parental effects in ecology and evolution: mechanisms, processes and implications. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 1169-1177. doi: 10.1098/rstb.2008.0302
3. Barnes, B., and Dupre, J. (2008). Genomes and What to Make of Them. Chicago: University of Chicago Press.
4. Bateson, P. (1991). Are there principles of behavioural development?," in The Development and Integration ofBehaviour: Essays in Honour of Robert Hinde, ed P. Bateson (Cambridge: Cambridge UniversityPress), 19-39.
5. Bateson, P., and Martin, P. (1999). Designfor a Life. New York: Simon and Schuster.
6. Bechtel, W. (2008). Mental Mechanisms. Philosophical Perspectives on Cognitive Neuroscience. New York: Routledge.
7. Beck, S., and Niewohner, J. (2006). Somatographic investigations across levels of complexity. Biosocieties 1, 219-227. doi: 10.1017/s1745855206 050113
8. Benton, T. (1991). Biology and social science: why the return of the repressed should be given a (cautious) welcome. Sociology 25, 1-29. doi: 10. 1177/0038038591025001002
9. Bird, A. (2007). Perceptions of epigenetics. Nature 447, 396-398. doi: 10.1038/ nature05913
10. Bird, A., and Macleod, D. (2004). Reading the DNA methylation signal. Cold Spring Harb. Symp. Quant. Biol. 69, 113-118. doi: 10.1101/sqb.2004.69.113
11. Boas, F. (1910). United States Immigration Commission. Changes in BodilyForm of Descendants ofImmigrants. Washington, D.C.: Government Printing Office.
12. Bonduriansky, R. (2012). Rethinking Heredity Again. Trends Ecol. Evol. 27, 330-336. doi: 10.1016/j.tree.2012.02.003
13. Bonduriansky, R., and Day, T. (2009). Nongenetic inheritance and its evo-lutionary implications. Annu. Rev. Ecol. Evol. Syst. 40, 103-125. doi: 10. 1146/annurev.ecolsys.39.110707.173441
14. Borghol, N., Suderman, M., McArdle, W., Racine, A., Hallett, M., Pembrey, M., et al. (2012). Associations with early-life socio-economic position in adult DNA methylation. Int. J. Epidemiol. 41, 62-74. doi: 10.1093/ije/dyr147
15. Borrelli, E., Nestler, E. J., Allis, C. D., and Sassone-Corsi, P. (2008). Decoding the epigenetic language of neuronal plasticity. Neuron 60, 961-974. doi: 10.1016/j. neuron.2008.10.012
16. Bowler, P. (1984). E. W. MacBride's Lamarckian eugenics and its implications for the social construction of scientific knowledge. Ann. Sci. 41, 245-260. doi: 10. 1080/00033798400200251
17. Boyce, W. T., Sokolowski, M. B., and Robinson, G. E. (2012). Toward a newbiology of social adversity. Proc. Natl. Acad. Sci. U S A 109, 17143-17148. doi: 10. 1073/pnas.1121264109
18. Buchen, L. (2010). In their Nurture. Nature 467, 146-148. doi: 10.1038/467146a
19. Cacioppo, J. T., and Patrick, B. (2008). Loneliness: Human Nature and the Need for Social Connection. NewYork: W. W. Norton and Company.
20. Champagne, F. A. (2008). Epigenetic mechanisms and the transgenerational effects ofmaternal care. Front. Neuroendocrinol. 29:3. doi: 10.1016/j.yfrne.2008.03.003
21. Champagne, F. A. (2013a). Effects of stress across generations: why sex matters. Biol. Psychiatry 73, 2-4. doi: 10.1016/j.biopsych.2012.10.004
22. Champagne, F. A. (2013b). Epigenetics and developmental plasticity across species. Dev. Psychobiol. 55, 33-41. doi: 10.1002/dev.21036
23. Champagne, F. A., and Curley, J. P. (2008). Maternal regulation ofestrogen receptor a methylation. Curr. Opin. Pharmacol. 8, 735-739. doi: 10.1016/j.coph.2008. 06.018
24. Champagne, F. A., and Mashoodh, R. (2009). Genes in context: gene-environment interplay and the origins of individual differences in behavior. Curr. Dir. Psychol. Sci. 18, 127-131. doi: 10.1111/j.1467-8721.2009.01622.x
25. Clark, A. (2008). Supersizing the Mind: EmbodimentAction and Cognitive Extension. Oxford and New York: Oxford University Press.
26. Clark, A., and Chalmers, D. J. (1998). The extended mind. Analysis 58, 7-19. doi: 10. 1093/analys/58.1.7
27. Crick, F. H. C. (1958). On protein synthesis. Symp. Soc. Exp. Biol. XII, 139-163.
28. Danchin, E., Charmantier, A., Champagne, F. A., Mesoudi, A., Pujol, B., and Blanchet, S. (2011). Beyond DNA: integrating inclusive inheritance into an extended theory of evolution. Nat. Rev. Genet. 12, 475-486. doi: 10. 1038/nrg3028
29. Danchin, E. (2013). Avatars of information. TrendsEcol. Evol. 28, 351-358. doi: 10.1016/j.tree.2013.02.010
30. Daxinger, L., and Whitelaw, E. (2010). Transgenerational epigenetic inheritance: more questions than answers. Genome Res. 20, 1623-1628. doi: 10.1101/gr. 106138.110
31. Day, D., and Sweatt, J. (2011). Cognitive neuroepigenetics: a role for epigenetic mechanisms in learning and memory. Neurobiol. Learn. Mem. 96, 2-12. doi: 10. 1016/j.nlm.2010.12.008
32. Dulac, C. (2010). Brain function and chromatin plasticity. Nature 465, 728-735. doi: 10.1038/nature09231
33. Dupras, C., Ravitsky, V., and Williams-Jones, B. (2012). Epigenetics and the environment in bioethics. Bioethics 1-8. doi: 10.1111/j.1467-8519.2012.02007.x
34. Dupre, J. (2012). Processes ofLife: Essays in the Philosophy of Biology. Oxford, UK: Oxford University Press.
35. Elman, J., Bates, E., Johnson, M., Karmiloff-Smith, A., Parisi, D., and Plunkett, K. (1996). Rethinking Innateness: A Connectionist Perspective on Development. Cambridge, MA: MIT Press.
36. ENCODE Project Consortium (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816. doi: 10.1038/nature05874
37. ENCODE Project Consortium (2012). An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74. doi: 10.1038/nature11247
38. Fagiolini, M., Jensen, C. L., and Champagne, F. A. (2009). Epigenetic influences on brain development and plasticity. Curr. Opin. Neurobiol. 19, 207-212. doi: 10. 1016/j.conb.2009.05.009
39. Farah, M. J., Shera, D. M., Savage, J. H., Betancourt, L., Giannetta, J. M., Brodsky, N. L., et al. (2006). Childhood poverty: specific associations with neurocognitive development. BrainRes. 1110, 166-174. doi: 10.1016/j.brainres.2006.06.072
40. Fass, D. M., Schroeder, F. A., Perlis, R. H., and Haggarty, S. J. (2014). Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience 264, 112-130. doi: 10.1016/j.neuroscience.2013.01.041
41. Feil, R., and Fraga, M. (2012). Epigenetics and the environment: emerging patterns and implications. Nat. Rev. Genet. 13, 97-109. doi: 10.1038/nrg3142
42. Feng, J., and Fan, G. (2009). The role of DNA methylation in the central nervous system and neuropsychiatric disorders. Int. Rev. Neurobiol. 89, 67-84. doi: 10. 1016/S0074-7742(09)89004-1
43. Francis, D., Diorio, J., Liu, D., and Meaney, M. J. (1999). Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286, 1155-1158. doi: 10.1126/science.286.5442.1155
44. Francis, R. (2011). Epigenetics: The Ultimate Mystery of Inheritance. New York: W.W. Norton.
45. Franklin, T., Russig, H., Weiss, I. C., Graff, J., Linder, N., Michalon, A., et al. (2010). Epigenetic transmission of the impact of early stress across generations. Biol. Psychiatry 68, 408-415. doi: 10.1016/j.biopsych.2010.05.036
46. Gapp, K., Woldemichael, B. T., Bohacek, J., and Mansuy, I. M. (2014). Epigenetic regulation in neurodevelopment and neurodegenerative diseases. Neuroscience 264, 99-111. doi: 10.1016/j.neuroscience.2012.11.040
47. Gilbert, S. F. (2003). "The reactive genome," in Origination of Organismal Form: Beyond the Gene in Developmental and Evolutionary Biology, eds G. B. Muller and S. A. Newman (Cambridge, MA: MIT Press), 87-101.
48. Gissis, S. and Jablonka, E. (2011). Transformations of Lamarckism. Cambridge, Mass: MIT Press.
49. Gluckman, P., Hanson, M. A., Bateson, P., Beedle, A. S., Law, C. M., Bhutta, Z. A., et al. (2009). Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet 373, 1654-1657. doi: 10.1016/s0140-6736(09)60234-8
50. Gluckman, P., Hanson, M. A., Beedle, A. S., Buklijas, T. and Low, F. M. (2011). "Epigenetics of human disease," in Epigenetics: Linking Genotype and Phenotype in Development and Evolution, eds B. Hallgrimsson and B. K. Hall (Berkeley: University of California Press), 398-423.
51. Gottlieb, G. (1997). Synthesizing Nature and Nurture: Prenatal Roots of Instinctive Behaviour. Hillsdale, NJ: Lawrence Erlbaum Associates.
52. Griesemer, J. (2002). What is "epi" about epigenetics? Ann. NY Acad. Sci. 981, 97-110. doi: 10.1111/j.1749-6632.2002.tb04914.x
53. Griffiths, P., and Stotz, K. (2013). Genetics and Philosophy. Cambridge: Cambridge University Press.
54. Griffiths, P. E. (2002). What is innateness. Monist 85, 70-85. doi: 10.5840/monist20028518
55. Griffiths, P. E. (2009). "The distinction between innate and acquired characteristics," in Stanford Encyclopedia of Philosophy. (Stanford, CA: Metaphysics Research Laboratory, Stanford University), accessible @: http://plato.stanford.edu/entries/innate-acquired/
56. Griffiths, P. E., and Gray, R. D. (1994). Developmental systems and evolutionary explanation. J. Philos. 6, 277-304. doi: 10.2307/2940982
57. Guo, J., Ma, D. K., Mo, H., Ball, M. P., Jang, M. H., Bonaguidi, M. A., et al. (2011). Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat. Neurosci. 14, 1345-1351. doi: 10.1038/nn.2900
58. Guthman, J., and Mansfield, B. (2012). The implications of environmental epigenetics: a new direction for geographic inquiry on health, space and nature-society relations. Prog. Hum. Geogr. doi: 10.1177/0309132512463258. [Epub ahead of print].
59. Hackman, D. A., Farah, M. J., and Meaney, M. J. (2010). Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat. Rev. Neurosci. 11, 651-659. doi: 10.1038/nrn2897
60. Haig, D. (2004). The (dual) origin of epigenetics. Cold Spring Harb. Symp. Quant. Biol. 69, 67-70. doi: 10.1101/sQ16.2004.69.67
61. Haig, D. (2012). The epidemiology of epigenetics. Int. J. Epidemiol. 41, 13-16.
62. doi: 10.1093/ije/dyr183
63. Hallgrimsson, B., and Hall, B. K. (Ed.) (2011). Epigenetics: Linking Genotype and Phenotype in Development and Evolution. Berkeley: University of California Press.
64. Hawkley, L., and Cacioppo, J. (2010). Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann. Behav. Med. 40, 218-227. doi: 10.1007/s12160-010-9210-8
65. Hedlund, M. (2012). Epigenetic responsibility. Med. Stud. 3, 171-183. doi: 10.1007/s12376-011-0072-6
66. Hitchins, M. P. (2007). Inheritance of a cancer-associated MLH1 germ-line epimutation. N. Engl. J. Med. 356, 697-705. doi: 10.1056/NEJMoa064522
67. Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., et al. (2008). Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl. Acad. Sci. USA 105, 17046-17049. doi: 10. 1073/pnas.0806560105
68. Hoag, H. (2011). Are your genes your destiny? Mc Gill News, Spring Summer: http://publications.mcgill.ca/mcgillnews/2011/06/01/are-your-genes-your-destiny-not-if-your-mom-has-anything-to-say-about-it/
69. Hsieh, J., and Heisch, A. J. (2010). Epigenetics, hippocampal neurogenesis and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol. Dis. 39, 73-84. doi: 10.1016/j.nbd.2010.01.008
70. Hyman, S. (2009). How adversity gets under the skin. Nat. Neurosci. 12, 241-243. doi: 10.1038/nn0309-241
71. Jablonka, E., and Lamb, M. (1995). Epigenetic Inheritance and Evolution.The LamarckianDimension. Oxford: OxfordUniversityPress.
72. Jablonka, E., and Lamb, M. (2002). The changing concept of epigenetics. Ann. N Y Acad. Sci. 981, 82-96. doi: 10.1111/j.1749-6632.2002.tb04913.x
73. Jablonka, E., and Lamb, M. (2005). Evolution in FourDimensions. Cambridge, MA: MIT Press.
74. Jablonka, E., and Raz, G. (2009). Transgenerational epigenetic inheritance: prevalence, mechanisms and implications for the study of heredity and evolution. Q. Rev. Biol. 84, 131-176. doi: 10.1086/598822
75. Jirtle, R. (2012). Epigenetics: how genes and environment interact. Lecture delivered at the NIH director's Wednesday afternoon lecture series. April 18, 2012, accessed at on Nov 1st, 2013.
76. Kappeler, L., and Meaney, M. (2010). Epigenetics and parental effects. Bioessays 32, 818-827. doi: 10.1002/bies.201000015
77. Keller, E. F. (2011). Genes, genomes andgenomics. Biol. Theory 6, 132-140.
78. doi: 10.1007/s13752-012-0014-x
79. Kishiyama, M., Boyce, W., Jimenez, A., Perry, L., and Knight, R. (2009). Socioeconomic disparities affect prefrontal function in children. J. Cogn. Neurosci. 21, 1106-1115. doi: 10.1162/jocn.2009.21101
80. Krieger, N. (2001). Theories for social epidemiology in the 21st century: an ecosocial perspective. Int. J. Epidemiol. 30, 668-677. doi: 10.1093/ije/ 30.4.668
81. Krieger, N. (2011). Epidemiology and People's Health: Theory and Context. New York: Oxford University Press.
82. Krieger, N., and Davey Smith, G. (2004). "Bodies count" and body counts: social epidemiology and embodying inequality. Epidemiol. Rev. 26, 92-103. doi: 10. 1093/epirev/mxh009
83. Krieger, N. ed (2004). EmbodyingInequality: Epidemiologic Perspectives. Amityville, NY: Baywood Publishing.
84. Kucharski, R., Maleszka, J., Foret, S., and Maleszka, R. (2008). Nutritional control of reproductive status in honey bees via DNA methylation. Science 319, 1827-1830. doi: 10.1126/science.1153069
85. Kuzawa, C., and Sweet, E. (2009). Epigenetics and the embodiment of race: developmental origins of US racial disparities in cardiovascular health. Am. J. Hum. Biol. 21, 2-15. doi: 10.1002/ajhb.20822
86. Labrie, V., Pai, S., and Petronis, A. (2012). Epigenetics ofmajor psychosis: progress, problems and perspectives. Trends Genet. 28, 427-435. doi: 10.1016/j.tig.2012. 04.002
87. Landecker, H. (2011). Food as exposure: nutritional epigenetics and the new metabolism. BioSocieties 6, 167-194. doi: 10.1057/biosoc.2011.1
88. Landecker, H., and Panofsky, A. (2013). From social structure to gene regulation and back: a critical introduction to environmental epigenetics for sociology. Annu. Rev. Sociol. 39, 3332013;357. doi: 10.1146/annurev-soc-071312-145707
89. Lehrman, D. S. (1953).Acritique ofKonradLorenz's theoryof instinctive behavior. Q. Rev. Biol. 28, 337-363. doi: 10.1086/399858
90. Lehrman, D. S. (1970). "Semantic and conceptual issues in the nature-nurture problem," in Development and Evolution of Behavior, eds R. Aronson, E. Tobach, D. S. Lehrman and J. S. Rosenblatt (San Francisco, CA: Freeman), 17-52.
91. Levenson, J. M., and Sweatt, J. D. (2005). Epigenetic mechanisms in memory formation. Nat. Rev. Neurosci. 6, 108-118. doi: 10.1038/nrn1604
92. Levenson, J., and Sweatt, J. (2006). Memory. Cell. Mol. Life Sci. 63, 1009-1016. doi: 10.1007/s00018-006-6026-6
93. Lewkowicz, D. J. (2010). "Nature and nurture in perception," in Sage Encyclopaedia of Perception, edE. Goldstein (Thousand Oaks, CA: Sage Publications), 611-616.
94. Lock, M. (2005). Eclipse of the gene and the return of divination. Curr. Anthropol. 46, S47-S70. doi: 10.1086/432452
95. Lupien, S. J., King, S., Meaney, M. J., and McEwen, B. S. (2000). Child's stress hormone levels correlate with mother's socioeconomic status and depressive state. Biol. Psychiatry 48, 976-980. doi: 10.1016/s0006-3223(00)00965-3
96. Lyko, F., Foret, S., Kucharski, R., Wolf, S., Falckenhayn, C., and Maleszka, R. (2010). The honey bee epigenomes: differential methylation of brain DNA in queens and workers. PLoS Biol. 8:e1000506. doi: 10.1371/journal.pbio.1000506
97. Maher, B. (2008). Personal genomes: the case of the missing heritability. Nature 456, 18-21. doi: 10.1038/456018a
98. Malabou, C. (2008). What Should We Do With Our Brain? New York: Fordham University Press.
99. Matusall, S., Kaufmann, I., and Christen, M. (2011). "The emergence of social neuroscience as an academic discipline," in The Oxford Handbook of Social Neuroscience, eds J. Decety and J. Cacioppo (Oxford: Oxford University Press), 9-27.
100. McGowan, P., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonte, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342-348. doi: 10.1038/nn. 2270
101. McGowan, P., Sasaki, A., Huang, T., Unterberger, A., Suderman, M., Ernst, C., et al. (2008). Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One 3:e2085. doi: 10.1371/journal.pone. 0002085
102. McGowan, P., and Szyf, M. (2010). The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol. Dis. 39, 66-72. doi: 10. 1016/j.nbd.2009.12.026
103. McGuinness, D., McGlynn, L. M., Johnson, P. C., MacIntyre, A., Batty, G. D., Burns, H., et al. (2012). Socio-economic status is associated with epigenetic differences in the pSoBidcohort. Int. J. Epidemiol. 41, 151-160. doi: 10.1093/ije/dyr215
104. Mclaughlin, M. (2012). Babies born into povertyare damaged forever before birth. The Scotsman January 24th.
105. Meaney, M. J. (2001a). Nature, nurture and the disunity of knowledge. Ann. N Y Acad. Sci. 935, 50-61. doi: 10.1111/j.1749-6632.2001.tb03470.x
106. Meaney, M. (2001b). Maternal care, gene expression and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 24, 1161-1192. doi: 10.1146/annurev.neuro.24.1.1161
107. Meaney, M., and Szyf, M. (2005). Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci. 28, 456-463. doi: 10.1016/j. tins.2005.07.006
108. Meaney, M. J., Szyf, M., and Seckl, J. R. (2007). Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol. Med. 13, 269-277. doi: 10.1016/j.molmed.2007.05.003
109. Meloni, M. (2011). Naturalism as an ontology of ourselves. Telos 155, 151-174. doi: 10.3817/0611155151
110. Meloni, M., and Testa, G. (in press). Scrutinizing the epigenetics revolution. BioSocieties.
111. Meloni, M. (2013a). Moralizing biology: the appeal and limits of the new compassionate view of nature. Hist. Human Sci. 26, 82-106. doi: 10. 1177/0952695113492163
112. Meloni, M. (2013b). Biology without biologism: social theory in a postgenomic age. Sociology Online First 31st October. http://soc.sagepub.com/content/early/2013/11/08/0038038513501944
113. Meloni, M. (2014). How biology became social and what it means for social theory. Sociol. Rev. Online First 26th March, http://online library.wiley.com/doi/10.1111/1467-954X.12151/abstract
114. Menary, R. (ed.) (2010). The Extended Mind. Cambridge, MA: MIT Press.
115. Mesoudi, A., Blanchet, S., Charmantier, A., Danchin, E., Fogarty, L., Jablonka, E., et al. (2013). Is non-genetic inheritance just a proximate mechanism? A corroboration of the extended evolutionary synthesis. Biol. Theory 7, 189-195. doi: 10.1007/s13752-013-0091-5
116. Miller, G. (2010). The seductive allure of behavioral epigenetics. Science 329, 24-27. doi: 10.1126/science.329.5987.24
117. Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., et al. (2009). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc. Natl. Acad. Sci. USA 106, 14716-14721. doi: 10.1073/pnas.0902971106
118. Moore, D. (2003). The Dependent Gene: The Fallacy of'Nature vs. Nurture' New York: Holt.
119. Morange, M. (2002). The relations between genetics and epigenetics. Ann. N Y Acad. Sci. 981, 50-60. doi: 10.1111/j.1749-6632.2002.tb04911.x
120. Morange, M. (2006). Post-genomics, between reduction and emergence. Synthese 151, 355-360. doi: 10.1007/s11229-006-9029-9
121. Moss, L. (2003). What Genes Can't Do. Cambridge, MA: MIT Press.
122. Nanney, D. (1958). Epigenetic control systems. Proc. Natl. Acad. Sci. USA 44, 712-717.
123. doi: 10.1073/pnas.44.7.712
124. Nestler, E. J. (2009). Epigenetic mechanism in psychiatry. Biol. Psychiatry 65, 189-190. doi: 10.1016/j.biopsych.2008.10.030
125. Niewohner, J. (2011). Epigenetics: embedded bodies and the molecularization of biography and milieu. BioSocieties 6, 279-298. doi: 10.1057/biosoc. 2011.4
126. Nijhout, H. F. (1990). Metaphors and the role of gene in development. Bioessays 12, 441-446. doi: 10.1002/bies.950120908
127. Noble, K. G., McCandliss, B. D., and Farah, M. J. (2007). Socioeconomic gradients predict individual differences in neurocognitive abilities. Dev. Sci. 10, 464-480. doi: 10.1111/j.1467-7687.2007.00600.x
128. Noble, K. G., Norman, M. F., and Farah, M. J. (2005). Neurocognitive correlates of socioeconomic status in kindergarten children. Dev. Sci. 8, 74-87. doi: 10. 1111/j.1467-7687.2005.00394.x
129. Noble, K. G., Houston, S. M., Kan, E., and Sowell, E. R. (2012). Neural correlates of socioeconomic status in the developing human brain. Dev. Sci. 15, 516-527. doi: 10.1111/j.1467-7687.2012.01147.x
130. Noe, A. (2009). Out of Our Heads: Why You Are Not Your Brain and Other Lessons from theBiology of Consciousness. New York: Farrar Strauss.
131. Oyama, S., Griffiths, P. E., and Gray, R. D. (2001). Cycles of Contingency: Developmental Systems and Evolution. Cambridge, MA: MIT Press.
132. Oyama, S. (2000a[1985]). The Ontogeny of Information: Developmental Systems and Evolution. Durham, NC and London: Duke University Press.
133. Oyama, S. (2000b). Evolution's Eye: A Systems View of the Biology-Culture Divide. Durham, NC and London: Duke University Press.
134. Painter, R. C., Osmond, C., Phillips, D. I. W., Hanson, M. A., and Roseboom, T. J. (2008). Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG 115, 1243-1249. doi: 10.1111/j. 1471-0528.2008.01822.x
135. Papadopoulos, D. (2011). The imaginary of plasticity: neural embodiment, epigenetics and ectomorphs. Sociol. Rev. 59, 433-456. doi: 10.1111/j.1467-954x. 2011.02025.x
136. Pennisi, E. (2012). ENCODE projects writes euology for junk DNA. Science 337, 1159-1161. doi: 10.1126/science.337.6099.1159
137. Pigliucci, M. and Muller, G. B. (2010). Evolution: theExtended Synthesis. Cambridge Mass: MIT Press.
138. Pigliucci, M. (2001). Phenotypic Plasticity: Beyond Nature and Nurture. Baltimore, MD: Johns Hopkins University Press.
139. Ptak, C., and Petronis, A. (2010). Epigenetic approaches to psychiatric disorders. Dialogues Clin. Neurosci. 12, 25-35.
140. Ptashne, M. (2007). On the use of the word 'epigenetics'. Curr. Biol. 17, R233-R236. doi: 10.1016/j.cub.2007.02.030
141. Racine, E., Bar-Ilan, O., and Illes, J. (2005). fMRI in the public eye. Nat. Rev. Neurosci. 6, 159-164. doi: 10.1038/nrn1609
142. Rao, H., Betancourt, L., Giannetta, J. M., Brodsky, N. L., Korczykowski, M., Avants, B. B., et al. (2010). Early parental care is important for hippocampal maturation: evidence from brain morphology in humans. Neuroimage 49, 1144-1150. doi: 10.1016/j.neuroimage.2009.07.003
143. Rassoulzadegan, M., Grandjean, V., Gounon, P., Vincent, S., Gillot, I., and Cuzin, F. (2006). RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature 441, 469-474. doi: 10.1038/nature04674
144. Richardson, S. (in press). "Maternal bodies in the postgenomic order: gender and the explanatory landscape of epigenetics," in Postgenomics, eds Richardson and Stevens (Durham: Duke Univ Press)
145. Richards, E. J. (2006). Inherited epigenetic variation-revisiting soft inheritance. Nat. Rev. Genet. 7, 395-400. doi: 10.1038/nrg1834
146. Robert, J. S. (2004). Embryology Epigenesis and Evolution: Taking Development Seriously. Cambridge: Cambridge University Press.
147. Rose, N. (2013). The human sciences in a biological age. Theory Cult. Soc. 30, 3-34. doi: 10.1177/0263276412456569
148. Rothstein, M. A., Cai, Y., and Marchant, G. E. (2009). The ghost in our genes: legal and ethical implications of epigenetics. Health Matrix Clevel. 19, 1-62.
149. Russo, V. E. A., Martienssen, R. A., and Riggs, A. D. (1996). Epigenetic Mechanisms of Gene Regulation. Woodbury NY: Cold Spring Harbor Laboratory Press.
150. Saavedra-Rodriguez, L., and Feig, L. A. (2013). Chronic social instability induces anxiety and defective social interactions across generations. Biol. Psychiatry 73, 44-53. doi: 10.1016/j.biopsych.2012.06.035
151. Shaw, M., Tunstall, H., and Davey Smith, G. (2003). Seeing social position: visualiz-ing class in life and death. Int. J. Epidemiol. 32, 332-335. doi: 10.1093/ije/dyg176
152. Shenk, D. (2010). The Genius in all of Us: The New Science of Genes Talent and Human Potential. London: Icon.
153. Shonkoff, J. P., Boyce, T. W., and McEwen, B. S. (2009). Neuroscience, molecular biology and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA 301, 2252-2259. doi: 10. 1001/jama.2009.754
154. Singh, I. (2012). Human development, nature and nurture: working beyond the divide. BioSocieties 7, 308-321. doi: 10.1057/biosoc.2012.20
155. Stankiewicz, A., Swiergiel, A., and Lisowski, P. (2013). Epigenetics of stress adaptations in the brain. Brain Res. Bull. 98, 76-92. doi: 10.1016/j.brainresbull. 2013.07.003
156. Stotz, K. (2006). With genes like that, who needs an environment? Postgenomics' argument for the ontogeny of information. Philos. Sci. 73, 905-917. doi: 10. 1086/518748
157. Stotz, K. (2008). The ingredients for a postgenomic synthesis of nature and nurture. Philos. Psychol. 21, 359-381. doi: 10.1080/09515080802200981
158. Sweatt, J. D. (2013). The emerging field of neuroepigenetics. Neuron 80, 624-632. doi: 10.1016/j.neuron.2013.10.023
159. Thompson, E. (2007). Mind in Life: Biology Phenomenology and the Sciences of Mind. Cambridge, MA: Harvard University Press.
160. Tsankova, N., Renthal, W., Kumar, A., and Nestler, E. (2007). Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8, 355-367. doi: 10.1038/ nrn2132
161. Uller, T. (2013). "Non-genetic inheritance and evolution," in Philosophy of Biology: a Companion for Educators, ed K. Kampourakis (Springer Verlag).
162. Van Speybroeck, L. (2002). From epigenesis to epigenetics the case of C. H. Waddington. Ann. N.Y. Acad. Sci. 981, 61-81. doi: 10.1111/j.1749-6632.2002. tb04912.x
163. Veenendaal, M. V. E., Painter, R. C., de Rooij, S. R., Bossuyt, P. M. M., van der Post, J. A. M., Gluckman, P. D., et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG 120, 548-554. doi: 10. 1111/1471-0528.12136
164. Vineis, P., Stringhini, S., and Porta, M. (2013). The environmental roots of non-communicable diseases (NCDs) and the epigenetic impacts of globalization. Environ. Res. doi: 10.1016/j.envres.2014.02.002. [Epub ahead of print].
165. Waddington, C. H. (2012) reprinted. The epigenotype. Int. J. Epidemiol. 41, 10-13. doi: 10.1093/ije/dyr184
166. Waddington, C. (1968). Towards a Theoretical Biology (vol. I.). Edinburgh: Edinburgh University Press.
167. Wagner, K. D., Wagner, N., Ghanbarian, H., Grandjean, V., Gounon, P., Cuzin, F., et al. (2008). RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse. Dev. Cell 14, 962-969. doi: 10.1016/j.devcel.2008. 03.009
168. Wastell, D., and White, S. (2012). Blinded by neuroscience: social policy, the family and the infant brain. Fam. Relatsh. Soc. 1, 397-414. doi: 10. 1332/204674312x656301
169. Waterland, R. A., and Jirtle, R. L. (2004). Early nutrition, epigenetic changes at transposons and imprinted genes and enhanced susceptibility to adult chronic diseases. Nutrition 20, 63-68. doi: 10.1016/j.nut.2003.09.011
170. Waterland, R. A., and Jirtle, R. L. (2003). Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol. 23, 5293-5300. doi: 10.1128/mcb.23.15.5293-5300.2003
171. Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., et al. (2004). Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847-854. doi: 10.1038/nn1276
172. Weaver, I. C., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., et al. (2005). Reversal of maternal programming of stress responses in adult offspring through. J. Neurosci. 25, 11045-11054. doi: 10.1523/jneurosci. 3652-05.2005
173. Wells, J. (2010). Maternal capital and the metabolic ghetto: an evolutionary perspective on the transgenerational basis of health inequalities. Am. J. Hum. Biol. 22, 1-17. doi: 10.1002/ajhb.20994
174. West, M. J., and King, A. P. (1987). Settling nature and nurture into an ontogenetic niche. Dev. Psychobiol. 20, 549-562. doi: 10.1002/dev.420200508
175. West-Eberhard, M. J. (2003). Developmental Plasticity and Evolution. Oxford: Oxford University Press.
176. Woldemichael, B. T., Bohacek, J., Gapp, K., Mansuy, I. (2014). "Epigenetics of memory and plasticity," in Progress in Molecular Biology and Translational Science (Vol. 122), eds Z. U. Khan and E. C. Muly, (Burlington: Academic Press), 305-340.
177. Zannas, A. S., and West, A. E. (2014). Epigenetics and the regulation of stress vulnerability and resilience. Neuroscience 264, 157-170. doi: 10.1016/j. neuroscience.2013.12.003