Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl 4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways

FEBS Letters

Volumn 588, Issue 12, 2014, Pages 2095-2100

  Ji, Lingling ^a   Xue, Ruyi ^a   Tang, Wenqing ^a   Wu, Weibin ^a   Hu, Tingting ^a   Liu, Xijun ^a   Peng, Xiaomin ^a   Gu, Jianxin ^a   Chen, She ^a   Zhang, Si ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Carbon tetrachloride; Hepatic stellate cell; Liver fibrosis; mitogen activated protein kinases; NF B; Toll like receptor 2

Indexed keywords

CARBON TETRACHLORIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FIBROGENESIS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL;

MUS;

CARBON TETRACHLORIDE; HEPATIC STELLATE CELL; LIVER FIBROSIS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-ΚB; TOLL LIKE RECEPTOR 2;

ANIMALS; CARBON TETRACHLORIDE; COLLAGEN; CYTOKINES; DOWN-REGULATION; GENE KNOCKOUT TECHNIQUES; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2;

EID: 84901420610     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.04.042     Document Type: Article

References (34)

1. S.C. Hasenfuss, L. Bakiri, M.K. Thomsen, R. Hamacher, and E.F. Wagner The AP-1 transcription factor Fra-1 is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism Hepatology 2013
2. V. Krizhanovsky et al. Senescence of activated stellate cells limits liver fibrosis Cell 134 2008 657 667
3. P.S. Chu et al. C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice Hepatology 58 2013 337 350
4. A. Moles et al. Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response Hepatology 57 2013 817 828
5. T. Sonoyama et al. Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide FEBS Lett. 583 2009 2067 2070
6. T. Aoyama, S. Inokuchi, D.A. Brenner, and E. Seki CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice Hepatology 52 2010 1390 1400
7. E. Seki, S. De Minicis, C.H. Osterreicher, J. Kluwe, Y. Osawa, D.A. Brenner, and R.F. Schwabe TLR4 enhances TGF-beta signaling and hepatic fibrosis Nat. Med. 13 2007 1324 1332 (Pubitemid 350073596)
8. R. Bataller, and D.A. Brenner Liver fibrosis J. Clin. Invest. 115 2005 209 218 (Pubitemid 40385459)
9. K. Jagavelu, C. Routray, U. Shergill, S.P. O'Hara, W. Faubion, and V.H. Shah Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver Hepatology 52 2010 590 601
10. A. Mencin, J. Kluwe, and R.F. Schwabe Toll-like receptors as targets in chronic liver diseases Gut 58 2009 704 720
11. X. Junjie et al. The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility BMC Cancer 12 2012 57
12. H.S. Kim, H. Go, S. Akira, and D.H. Chung TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice J. Immunol. 187 2011 4007 4017
13. I.T. Lee, C.W. Lee, W.H. Tung, S.W. Wang, C.C. Lin, J.C. Shu, and C.M. Yang Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses Am. J. Pathol. 176 2010 1671 1684
14. H. Lin et al. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice Hepatology 57 2013 171 182
15. C.T. Tu, Q.Y. Yao, B.L. Xu, J.Y. Wang, C.H. Zhou, and S.C. Zhang Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression Food Chem. Toxicol. 50 2012 3343 3351
16. Y.H. Paik et al. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid Lab. Invest. 86 2006 676 686
17. K. Miura, L. Yang, N. van Rooijen, D.A. Brenner, H. Ohnishi, and E. Seki Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice Hepatology 57 2013 577 589
18. D. Jia et al. Up-regulation of RACK1 by TGF-beta1 promotes hepatic fibrosis in mice PLoS One 8 2013 e60115
19. J. Xu et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage Hepatology 52 2010 142 154
20. L. Tolosa, M. Morla, A. Iglesias, X. Busquets, J. Llado, and G. Olmos IFN-gamma prevents TNF-alpha-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-kappaB activity Cell Signal. 17 2005 1333 1342 (Pubitemid 41206643)
21. J.P. Pradere et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice Hepatology 2013
22. E. Bourbonnais, V.A. Raymond, C. Ethier, B.N. Nguyen, M.S. El-Leil, S. Meloche, and M. Bilodeau Liver fibrosis protects mice from acute hepatocellular injury Gastroenterology 142 130-139 2012 e4
23. Z. Tan et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation J. Immunol. 191 2013 1835 1844
24. K.R. Karlmark et al. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis Hepatology 50 2009 261 274
25. H.W. Zimmermann et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis PLoS One 5 2010 e11049
26. P. Hartmann, M. Haimerl, M. Mazagova, D.A. Brenner, and B. Schnabl Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice Gastroenterology 143 1330-40 2012 e1
27. A. Moles et al. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse J. Hepatol. 60 2013 782 791
28. E. Seki, and D.A. Brenner Toll-like receptors and adaptor molecules in liver disease: update Hepatology 48 2008 322 335 (Pubitemid 351975556)
29. M. Coenen et al. Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2 Lab. Invest. 91 2011 1375 1382
30. X.L. Chen et al. High-mobility group box-1 induces proinflammatory cytokines production of Kupffer cells through TLRs-dependent signaling pathway after burn injury PLoS One 7 2012 e50668
31. F. Marra et al. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat Hepatology 30 1999 951 958 (Pubitemid 29458284)
32. J. Kluwe et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2010 347 359
33. T. Luedde, and R.F. Schwabe NF-kappaB in the liver - linking injury, fibrosis and hepatocellular carcinoma Nat. Rev. Gastroenterol. Hepatol. 8 2011 108 118
34. F. Oakley et al. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis Gastroenterology 128 2005 108 120 (Pubitemid 40039963)