Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B

Human Pathology

Volumn 44, Issue 8, 2013, Pages 1665-1671

  Mathai, Alka Mary ^a   Alexander, Jacob ^a   Kuo, Fang Ying ^b   Torbenson, Michael ^c   Swanson, Paul E ^a   Yeh, Matthew M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ground glass hepatocytes; Hepatitis B surface antigen; Hepatitis B virus infection; Hepatocellular carcinoma; Histopathology

Indexed keywords

ALPHA FETOPROTEIN; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; INFLAMMATION; LIVER CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER RESECTION; MALE; PROTEIN BLOOD LEVEL; TYPE II GROUND GLASS HEPATOCYTE; VIRUS LOAD;

GROUND-GLASS HEPATOCYTES; HCC; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS INFECTION; HEPATOCELLULAR CARCINOMA; HISTOPATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; VIRAL LOAD; YOUNG ADULT;

EID: 84880330401     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.01.020     Document Type: Article

References (35)

1. N. Kobayashi, N. Hiraoka, and W. Yamagami FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis Clin Cancer Res 13 2007 902 911
2. V.T. Nguyen, M.G. Law, and G.J. Dore Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden J Viral Hepat 16 2009 453 463
3. G.A. Lutchman, and M.A. Nguyen Screening for hepatocellular carcinoma after HBsAg clearance age before cirrhosis?: age before cirrhosis? J Clin Gastroenterol 45 2011 4 5
4. E. Hildt, B. Munz, G. Saher, K. Reifenberg, and P.H. Hofschneider The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice EMBO J 21 2002 525 535
5. N.H. Park, I.H. Song, and Y.H. Chung Chronic hepatitis B in hepatocarcinogenesis Postgrad Med J 82 2006 507 515
6. N.H. Park, I.H. Song, and Y.H. Chung Molecular pathogenesis of hepatitis-B-virus-associated hepatocellular carcinoma Gut Liver 1 2007 101 117
7. H.C. Wang, H.C. Wu, C.F. Chen, N. Fausto, H.Y. Lei, and I.J. Su Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress Am J Pathol 163 2003 2441 2449
8. I.J. Su, H.C. Wang, H.C. Wu, and W.Y. Huang Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection J Gastroenterol Hepatol 23 2008 1169 1174
9. K. Ishak, A. Baptista, and L. Bianchi Histological grading and staging of chronic hepatitis J Hepatol 22 1995 696 699
10. H.W. Tsai, Y.J. Lin, and P.W. Lin A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery Cancer 117 2011 2951 2960
11. M. Kojiro Pathology of Hepatocellular Carcinoma 2006 Blackwell publishing Ltd Oxford, UK
12. A.D. Burt, B.C. Portmann, and L.D. Ferrell MacSween's Pathology of the Liver 6th ed. 2012 Churchill Livingstone: Elsevier Philadelphia
13. S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, and A. Trotti American Joint Committee on Cancer: Cancer Staging Manual 7th ed. 2010 Springer New York 237 245
14. Y.H. Hsieh, I.J. Su, and H.C. Wang Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage Carcinogenesis 25 2004 2023 2032
15. Z. Xu, G. Jensen, and T.S. Yen Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum J Virol 71 1997 7387 7392
16. Z. Xu, and T.S. Yen Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles J Virol 70 1996 133 140
17. F.V. Chisari, P. Filippi, and A. McLachlan Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice J Virol 60 1986 880 887
18. Y. Zheng, W.L. Chen, S.G. Louie, T.S. Yen, and J.H. Ou Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology 45 2007 16 21
19. Y.F. Fan, C.C. Lu, and W.C. Chen Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection Hepatology 33 2001 277 286
20. C.M. Chu, and Y.F. Liaw Membrane staining for hepatitis B surface antigen on hepatocytes: a sensitive and specific marker of active viral replication in hepatitis B J Clin Pathol 48 1995 470 473
21. P.C. Tai, F.M. Suk, W.H. Gerlich, A.R. Neurath, and C. Shih Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants Virology 292 2002 44 58
22. Z.M. Huang, and T.S. Yen Dysregulated surface gene expression from disrupted hepatitis B virus genomes J Virol 67 1993 7032 7040
23. S. Hadziyannis, M.A. Gerber, C. Vissoulis, and H. Popper Cytoplasmic hepatitis B antigen in "ground-glass" hepatocytes of carriers Arch Pathol 96 1973 327 330
24. I. Rusyn, S. Asakura, and B. Pachkowski Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators Cancer Res 64 2004 1050 1057
25. F.V. Chisari, and C. Ferrari Hepatitis B virus immunopathogenesis Annu Rev Immunol 13 1995 29 60
26. K. Abe, S.N. Thung, and H.C. Wu Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children Cancer Sci 100 2009 2249 2254
27. C.H. Chen, C.H. Hung, and C.M. Lee Pre S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients Gastroenterology 133 2007 1466 1474
28. C.J. Liu, H.R. Cheng, and C.L. Chen Effects of hepatitis B virus precore and basal core promoter mutations on the expression of viral antigens: genotype B vs C J Viral Hepat 18 2011 e482 e490
29. J.H. Kao, P.J. Chen, M.Y. Lai, and D.S. Chen Acute exacerbations of chronic hepatitis B are rarely associated with superinfection of hepatitis B virus Hepatology 34 2001 817 823
30. W.S. Mason, C. Liu, C.E. Aldrich, S. Litwin, and M.M. Yeh Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection J Virol 84 2010 8308 8315
31. J.C. Yang, C.F. Teng, and H.C. Wu Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis Hepatology 49 2009 1962 1971
32. F.V. Chisari, P. Filippi, and J. Buras Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice Proc Natl Acad Sci U S A 84 1987 6909 6913
33. Z. Schaff, C.C. Hsia, I. Sarosi, and E. Tabor Overexpression of transforming growth factor-alpha in hepatocellular carcinoma and focal nodular hyperplasia from European patients Hum Pathol 25 1994 644 651
34. M. Ono, K. Morisawa, and J. Nie Transactivation of transforming growth factor alpha gene by hepatitis B virus preS1 Cancer Res 58 1998 1813 1816
35. M.E. Mendy, T. Welzel, and O.A. Lesi Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa J Viral Hepat 17 2010 115 122